‘Research’ versus ‘real-world’ patients: representativeness of participants in clinical trials of treatments for cocaine dependence
Carroll K, Nich C, McLellan A, McKay J, Rounsaville B. ‘Research’ versus ‘real-world’ patients: representativeness of participants in clinical trials of treatments for cocaine dependence. Drug And Alcohol Dependence 1999, 54: 171-177. PMID: 10217557, DOI: 10.1016/s0376-8716(98)00161-6.Peer-Reviewed Original ResearchConceptsClinical trialsCocaine dependenceClinical settingRegular clinical settingRigorous clinical trialsOutpatient clinical settingLarge national databaseRepresentativeness of participantsChallenging patientsResearch patientsClinical practiceMild formPatientsSubstance dependenceNational databaseTrialsRepresentativeness of subjectsLimited external validitySubjectsTreatmentExternal validityCocaine problemsIndividualsSetting