Chantal Vogels, PhD
Assistant Professor of Epidemiology (Microbial Diseases)Cards
Additional Titles
Affiliate Faculty, Yale Institute for Global Health
Contact Info
Epidemiology of Microbial Diseases
60 College Street
New Haven, CT 06510
United States
About
Titles
Assistant Professor of Epidemiology (Microbial Diseases)
Affiliate Faculty, Yale Institute for Global Health
Biography
I am an Assistant Professor in the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health. I have a background in ecology, medical entomology, virology, and genomics.
During my PhD at Wageningen University & Research, I studied the role of Culex pipiens mosquitoes in transmission of West Nile virus in Europe. My interdisciplinary project involved local mosquito surveillance in the field, vector competence studies in the laboratory, and modeling. These studies led to important insights in the role of climate as a limiting factor to transmission of West Nile virus in Europe. During my postdoc at the Yale School of Public Health, I shifted my focus to using genomics to understand the role of virus evolution in the unexpected scale and severity of the Zika virus epidemic in the Americas. Using a reverse genetics platform, we engineered Zika virus mutations and determined their impact on transmission by Aedes aegypti mosquitoes in the laboratory. Since the start of the COVID-19 pandemic, I temporarily shifted my research focus to utilize my expertise in molecular virology and genomics to respond to a global public health emergency. Our team led the laboratory development of a saliva-based test called SalivaDirect that received Emergency Use Authorization from the U.S. Food and Drug Administration, and we established the Yale SARS-CoV-2 Genomic Surveillance Initiative through which >25,000 SARS-CoV-2 samples were sequenced. Building on these experiences, we recently developed amplicon sequencing approaches for emerging viruses (i.e., human monkeypox virus) and arboviruses (i.e., dengue virus and Powassan virus) to uncover their patterns of emergence and spread.
In the Vogels Lab, we use experimental approaches to study the ecology, evolution, and epidemiology of arthropod-borne (arbo)viruses. By combining field, laboratory, and computational approaches, we investigate how complex interactions between arboviruses, their vectors, and the environment influence their transmission dynamics. Our goal is to increase our understanding of the drivers and barriers of arbovirus transmission to improve prevention and control strategies.
Appointments
Epidemiology of Microbial Diseases
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Wageningen University & Research, Laboratory of Entomology (2017)
- MSc
- Wageningen University & Research (2012)
- BSc
- Wageningen University & Research (2010)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0003-0027-6480- View Lab Website
Vogels Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Nathan Grubaugh, PhD
Akiko Iwasaki, PhD
Albert Ko, MD
Anne Wyllie, PhD
Chaney Kalinich, MPH
Benjamin Goldman-Israelow, MD/PhD
Zika Virus Infection
Dengue
Coinfection
Publications
2024
SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity
Peña-Hernández M, Alfajaro M, Filler R, Moriyama M, Keeler E, Ranglin Z, Kong Y, Mao T, Menasche B, Mankowski M, Zhao Z, Vogels C, Hahn A, Kalinich C, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach B, Homer R, Pyle A, Martinez D, Grubaugh N, Israelow B, Iwasaki A, Wilen C. SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity. Nature Microbiology 2024, 9: 2038-2050. PMID: 39075235, DOI: 10.1038/s41564-024-01765-z.Peer-Reviewed Original ResearchAltmetricConceptsBat coronavirusesRelatives of SARS-CoV-2Upper airwayUpper airways of miceEpithelial cellsHuman nasal epithelial cellsAirways of miceMajor histocompatibility complex class I.SARS-CoV-2Nasal epithelial cellsHistocompatibility complex class I.Human bronchial epithelial cellsGenetic similarityBronchial epithelial cellsInnate immune restrictionCoronavirus replicationFunctional characterizationMolecular cloningReduced pathogenesisImpaired replicationBat virusCoronavirus pathogenesisPandemic potentialHigh-risk familiesImmune restrictionDengueSeq: a pan-serotype whole genome amplicon sequencing protocol for dengue virus
Vogels C, Hill V, Breban M, Chaguza C, Paul L, Sodeinde A, Taylor-Salmon E, Ott I, Petrone M, Dijk D, Jonges M, Welkers M, Locksmith T, Dong Y, Tarigopula N, Tekin O, Schmedes S, Bunch S, Cano N, Jaber R, Panzera C, Stryker I, Vergara J, Zimler R, Kopp E, Heberlein L, Herzog K, Fauver J, Morrison A, Michael S, Grubaugh N. DengueSeq: a pan-serotype whole genome amplicon sequencing protocol for dengue virus. BMC Genomics 2024, 25: 433. PMID: 38693476, PMCID: PMC11062901, DOI: 10.1186/s12864-024-10350-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAmplicon sequencing protocolsPrimer schemeSequencing protocolGenomic surveillanceDengue virus serotypesAmplicon sequencing workflowClinical specimensHigh genome coverageWhole-genome sequencingDengue virusVirus serotypesGenome coverageVirus stocksGenetic diversitySequencing instrumentsSequencing workflowGenotype VIDiverse serotypesSequence of samplesGenotype IVPrimersSurveillance of dengue virusSerotypesVirus copiesSerotype-specificTravel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
Taylor-Salmon E, Hill V, Paul L, Koch R, Breban M, Chaguza C, Sodeinde A, Warren J, Bunch S, Cano N, Cone M, Eysoldt S, Garcia A, Gilles N, Hagy A, Heberlein L, Jaber R, Kassens E, Colarusso P, Davis A, Baudin S, Rico E, Mejía-Echeverri Á, Scott B, Stanek D, Zimler R, Muñoz-Jordán J, Santiago G, Adams L, Paz-Bailey G, Spillane M, Katebi V, Paulino-Ramírez R, Mueses S, Peguero A, Sánchez N, Norman F, Galán J, Huits R, Hamer D, Vogels C, Morrison A, Michael S, Grubaugh N. Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean. Nature Communications 2024, 15: 3508. PMID: 38664380, PMCID: PMC11045810, DOI: 10.1038/s41467-024-47774-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDengue virusDENV-3Rates of severe diseaseMosquito-borne viral diseasePublic health threatPattern of spreadSevere diseaseLocal surveillanceGenomic epidemiologyEpidemiological patternsVirus surveillanceSurveillanceHealth threatSerotypesDiseaseIncreased rateDengueViral diseasesVirusInfected travelersFrequent outbreaksIntranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract
Mao T, Kim J, Peña-Hernández M, Valle G, Moriyama M, Luyten S, Ott I, Gomez-Calvo M, Gehlhausen J, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee C, Monteiro V, Lucas C, Dong H, Yang Y, Initiative Y, Gopinath S, Wilen C, Palm N, Dela Cruz C, Iwasaki A, Vogels C, Hahn A, Chen N, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Grubaugh N. Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2319566121. PMID: 38648490, PMCID: PMC11067057, DOI: 10.1073/pnas.2319566121.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsInterferon-stimulated genesRespiratory infectionsStrains of influenza A virusTreatment of respiratory viral infectionsRespiratory virus infectionsInfluenza A virusMouse model of COVID-19Respiratory viral infectionsNeomycin treatmentExpression of interferon-stimulated genesUpper respiratory infectionInterferon-stimulated gene expressionLower respiratory infectionsBroad spectrum of diseasesAdministration of neomycinRespiratory viral diseasesDisease to patientsUpper respiratory tractIntranasal deliveryCongenic miceIntranasal applicationNasal mucosaSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2A virusContribution of climate change to the spatial expansion of West Nile virus in Europe
Erazo D, Grant L, Ghisbain G, Marini G, Colón-González F, Wint W, Rizzoli A, Van Bortel W, Vogels C, Grubaugh N, Mengel M, Frieler K, Thiery W, Dellicour S. Contribution of climate change to the spatial expansion of West Nile virus in Europe. Nature Communications 2024, 15: 1196. PMID: 38331945, PMCID: PMC10853512, DOI: 10.1038/s41467-024-45290-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWest Nile virusEcological niche modelsExpansion of West Nile virusClimate changeWNV circulationNiche modelsNile virusMosquito-borne pathogensEffects of climate changeHuman population changeSpatial expansionContributions of climate changeWest Nile virus circulationEnvironmental changesPublic health threatHuman populationLand-useHuman influencePotential driversRisk of exposureLong-term trendsPopulation densityPopulation changeHealth threatClimateEarly Release - Introduction and Spread of Dengue Virus 3, Florida, USA, May 2022–April 2023 - Volume 30, Number 2—February 2024 - Emerging Infectious Diseases journal - CDC
Jones F, Morrison A, Santiago G, Rysava K, Zimler R, Heberlein L, Kopp E, , Saunders K, Baudin S, Rico E, Mejía-Echeverri Á, Taylor-Salmon E, Hill V, Breban M, Vogels C, Grubaugh N, Paul L, Michael S, Johansson M, Adams L, Munoz-Jordan J, Paz-Bailey G, Stanek D. Early Release - Introduction and Spread of Dengue Virus 3, Florida, USA, May 2022–April 2023 - Volume 30, Number 2—February 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 376-379. PMID: 38232709, PMCID: PMC10826764, DOI: 10.3201/eid3002.231615.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2023
Genomic epidemiology of West Nile virus in Europe
Koch R, Erazo D, Folly A, Johnson N, Dellicour S, Grubaugh N, Vogels C. Genomic epidemiology of West Nile virus in Europe. One Health 2023, 18: 100664. PMID: 38193029, PMCID: PMC10772404, DOI: 10.1016/j.onehlt.2023.100664.Peer-Reviewed Original ResearchCitationsAltmetricSurvey of white-footed mice (Peromyscus leucopus) in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses
Earnest R, Hahn A, Feriancek N, Brandt M, Filler R, Zhao Z, Breban M, Vogels C, Chen N, Koch R, Porzucek A, Sodeinde A, Garbiel A, Keanna C, Litwak H, Stuber H, Cantoni J, Pitzer V, Olarte Castillo X, Goodman L, Wilen C, Linske M, Williams S, Grubaugh N. Survey of white-footed mice (Peromyscus leucopus) in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses. Npj Viruses 2023, 1: 10. DOI: 10.1038/s44298-023-00010-4.Peer-Reviewed Original ResearchCitationsAltmetricThe known unknowns of Powassan virus ecology
Brackney D, Vogels C. The known unknowns of Powassan virus ecology. Journal Of Medical Entomology 2023, 60: 1142-1148. PMID: 37862099, PMCID: PMC10645372, DOI: 10.1093/jme/tjad095.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDevelopment of an amplicon-based sequencing approach in response to the global emergence of mpox
Chen N, Chaguza C, Gagne L, Doucette M, Smole S, Buzby E, Hall J, Ash S, Harrington R, Cofsky S, Clancy S, Kapsak C, Sevinsky J, Libuit K, Park D, Hemarajata P, Garrigues J, Green N, Sierra-Patev S, Carpenter-Azevedo K, Huard R, Pearson C, Incekara K, Nishimura C, Huang J, Gagnon E, Reever E, Razeq J, Muyombwe A, Borges V, Ferreira R, Sobral D, Duarte S, Santos D, Vieira L, Gomes J, Aquino C, Savino I, Felton K, Bajwa M, Hayward N, Miller H, Naumann A, Allman R, Greer N, Fall A, Mostafa H, McHugh M, Maloney D, Dewar R, Kenicer J, Parker A, Mathers K, Wild J, Cotton S, Templeton K, Churchwell G, Lee P, Pedrosa M, McGruder B, Schmedes S, Plumb M, Wang X, Barcellos R, Godinho F, Salvato R, Ceniseros A, Breban M, Grubaugh N, Gallagher G, Vogels C. Development of an amplicon-based sequencing approach in response to the global emergence of mpox. PLOS Biology 2023, 21: e3002151. PMID: 37310918, PMCID: PMC10263305, DOI: 10.1371/journal.pbio.3002151.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPublic health laboratoriesHealth laboratoriesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Monkeypox virusRespiratory syndrome coronavirus 2Ongoing coronavirus disease 2019 (COVID-19) pandemicAnatomical body sitesAtypical clinical presentationCoronavirus disease 2019 (COVID-19) pandemicSyndrome coronavirus 2Course of infectionDisease 2019 pandemicRapid outbreak responseWhole-genome sequencingHuman monkeypox virusCT valuesClinical presentationViral loadCoronavirus 2Viral DNA concentrationsPathogen whole-genome sequencingZika virusClinical specimensBody sites
Academic Achievements and Community Involvement
activity European Society for Vector Ecology
Professional OrganizationsBoard MemberDetails10/25/2017 - Presentactivity American Society for Tropical Medicine and Hygiene
Professional OrganizationsMemberDetails11/01/2018 - Presentactivity Marina van Damme Network
Professional OrganizationsBoard MemberDetails2020 - 2024honor COVID-19 Team Research Award
Yale University AwardYale School of Public HealthDetails05/13/2022United Statesactivity Yale Postdoctoral Association
Professional OrganizationsCoordinatorDetails2019 - 2020
Links & Media
News
- August 30, 2024Source: Everyday Health
Sloth Fever (Oropouche Virus) Comes to the U.S.
- August 29, 2024Source: ABC News
What you need to know about 'sloth fever' after 21 cases confirmed among US travelers
- August 16, 2024
The science behind the latest mpox global health emergency
- August 11, 2024Source: The Boston Globe
As climate change increases tick populations, vaccine development, tick control efforts lag
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Epidemiology of Microbial Diseases
60 College Street
New Haven, CT 06510
United States