2024
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?
Abdallah C, Tamman A. Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors? Expert Opinion On Therapeutic Targets 2024, ahead-of-print: 1-3. PMID: 39099083, DOI: 10.1080/14728222.2024.2389201.Peer-Reviewed Original ResearchMedial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepressionChallenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Asch R, Abdallah C, Carson R, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology 2024, 1-11. PMID: 39039139, DOI: 10.1038/s41386-024-01913-3.Peer-Reviewed Original ResearchStudies of depressionAnimal models of chronic stressPositron emission tomographyModel of chronic stressSV2A imagingSynaptic densitySignificant depressive symptomsDevelopment of novel radiotracersDepressive symptomsNeuropsychiatric disordersSymptom severityChronic stressDrug challengeSynaptic vesicle glycoprotein 2 ANeural markersAnimal modelsSynaptic alterationsSynaptogenesis in vivoPreliminary findingsIn vivo quantificationCentral nervous systemDepressionEmission tomographySV2ASV2A positron emission tomographyMapping the Depressed Brain Under Stress Using Multimodal Neuroimaging
Akiki T, Abdallah C. Mapping the Depressed Brain Under Stress Using Multimodal Neuroimaging. American Journal Of Psychiatry 2024, 181: 578-580. PMID: 38946274, DOI: 10.1176/appi.ajp.20240400.Peer-Reviewed Original ResearchFindings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficits366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original ResearchUltrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder
Tamman A, Abdallah C. Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder. Biological Psychiatry 2024, 95: 385-386. PMID: 38325915, DOI: 10.1016/j.biopsych.2023.12.022.Peer-Reviewed Original ResearchNeural differentiation of emotional faces as a function of interpersonal violence among adolescent girls
Tamman A, Abdallah C, Dunsmoor J, Cisler J. Neural differentiation of emotional faces as a function of interpersonal violence among adolescent girls. Journal Of Psychiatric Research 2024, 172: 90-101. PMID: 38368703, DOI: 10.1016/j.jpsychires.2024.02.015.Peer-Reviewed Original ResearchRepresentational similarity analysisInterpersonal violenceUnivariate activityNeutral facesFacial emotion processing taskEffects of trauma typeEmotion processing taskMultivoxel activity patternsMechanisms of riskFearful facesEmotional facesThreat processingFacial stimuliAbuse severityNeural alterationsPsychiatric diagnosisPsychiatric disordersTrauma typesPsychiatric medicationsRight hippocampusAssault severityNeural patternsPhysical assaultPhysical abuseUnique contributionsSmaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.Peer-Reviewed Original ResearchCorrection: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.Peer-Reviewed Original Research
2023
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abuseNeuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium
Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.Peer-Reviewed Original ResearchPsychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scoreGenetic predispositionModifiable psychosocial variablesAge-related morbidityGamma-glutamyl transferaseInflammatory biomarkersSystemic inflammationNational HealthApolipoprotein BMale veteransPsychosocial factorsVeterans StudySaliva samplesPsychosocial moderatorsPsychosocial variablesAntihistamine drugsMilitary veteransGrimAgeGrimAge accelerationInflammationUK BiobankDrugsRepresentative samplePredispositionBiological embedding of early trauma: the role of higher prefrontal synaptic strength
Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. Biological embedding of early trauma: the role of higher prefrontal synaptic strength. European Journal Of Psychotraumatology 2023, 14: 2246338. PMID: 37642398, PMCID: PMC10467533, DOI: 10.1080/20008066.2023.2246338.Peer-Reviewed Original ResearchConceptsEarly traumaApproach/avoidance tendenciesReward responsivityAvoidance tendenciesBehavioral inhibitionSynaptic strengthPutative measurePhysical healthBiological embeddingHealthy controlsLarge human samplePTSDSynaptic processesGlutamatergic synaptic strengthPsychiatric disordersHigher EPCHuman samplesStudy findingsGlutamatergic excitotoxicityPharmacological treatmentDirect measureMeasuresTraumaEmotionsSynaptic plasticityDSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder
Benfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.Peer-Reviewed Original ResearchPosttraumatic stress disorderTrauma typesBehavioral health problemsHealth problemsStress disorderMoral injuryParticipants' ratingsLife threatAftermath of violenceMental health problemsDSM-5 criteriaTraumatic eventsParticipants' endorsementClinical trialsDifferent traumasTyping schemeTraumatic lossAssessor judgementsService membersTraumaClinical researchersParticipantsUnique contextInjuryMilitary personnelNeural Integro-Differential Equations
Zappala E, O. Fonseca A, Moberly A, Higley M, Abdallah C, Cardin J, Van Dijk D. Neural Integro-Differential Equations. Proceedings Of The AAAI Conference On Artificial Intelligence 2023, 37: 11104-11112. DOI: 10.1609/aaai.v37i9.26315.Peer-Reviewed Original ResearchIntegro-differential equationsIntegral operatorsDifferential equationsContinuous dynamical systemsNon-local dynamicsDynamical systemsInitial conditionsEquationsNeural networkTime extrapolationOperatorsIntegralsFundamental problemSuch dynamicsLatent spaceDynamicsNon-local processesBrain activity recordingsBrain dynamicsData scienceDifferential componentsIntegrandGeneralizationTheoryNetworkPsychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans
Stanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.Peer-Reviewed Original ResearchConceptsBehaviors Interview-Short FormPosttraumatic stress disorderSelf-injurious thoughtsMilitary service membersService membersDiscriminant validitySelf-report measuresInterview-based measuresSuicidal ideationSelf-report questionnairesActive duty military service membersSuicide-related thoughtsActive duty service membersPTSD symptomsStress disorderRelated constructsGood convergentConvergent validityResponse formatPsychometric propertiesSuicide risk assessmentInterrater reliabilityHigh interrater reliabilityIdeationVeteransThe potential of ketamine for posttraumatic stress disorder: a review of clinical evidence
Ragnhildstveit A, Roscoe J, Bass L, Averill C, Abdallah C, Averill L. The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. Therapeutic Advances In Psychopharmacology 2023, 13: 20451253231154125. PMID: 36895431, PMCID: PMC9989422, DOI: 10.1177/20451253231154125.Peer-Reviewed Original ResearchPosttraumatic stress disorderClinical evidenceStress disorderMethyl-d-aspartate (NMDA) receptor antagonistLow patient engagementRobust antidepressant effectsOpen-label studyOnset of actionPotential of ketamineQuality of lifeMedical comorbiditiesAntidepressant effectsChart reviewRefractory casesDisease chronicityClinical presentationRandomized trialsCase reportDevastating conditionReceptor antagonistMajor depressionPharmacological approachesPsychiatric disordersPharmacological agentsTherapeutic safety
2022
Brain Imaging in Psychiatry: Time to Move From Regions of Interest and Interpretive Analyses to Connectomes and Predictive Modeling?
Abdallah C, Sheth S, Storch E, Goodman W. Brain Imaging in Psychiatry: Time to Move From Regions of Interest and Interpretive Analyses to Connectomes and Predictive Modeling? American Journal Of Psychiatry 2022, 180: 17-19. PMID: 36587267, DOI: 10.1176/appi.ajp.20220907.Peer-Reviewed Original ResearchReduced Prefrontal Synaptic Strength in Posttraumatic Stress Disorder (PTSD)
Abdallah C. Reduced Prefrontal Synaptic Strength in Posttraumatic Stress Disorder (PTSD). Biological Psychiatry 2022, 91: s34. DOI: 10.1016/j.biopsych.2022.02.103.Peer-Reviewed Original Research