2008
A proton‐independent function of ASIC in Ciona intestinalis
Coric T, Passamaneck Y, Zhang P, Di Gregorio A, Canessa C. A proton‐independent function of ASIC in Ciona intestinalis. The FASEB Journal 2008, 22: 945.4-945.4. DOI: 10.1096/fasebj.22.1_supplement.945.4.Peer-Reviewed Original ResearchCiona intestinalisAcid-sensitive ion channelsChordate nervous systemAscidian Ciona intestinalisLarval nervous systemPhysiological genomicsAdult nervous systemSequence similarityHigher vertebratesHeterologous systemsLarval neuronsSpliced formsASIC functionNervous systemLarval swimmingIon channelsASIC genesExtracellular protonsSodium channelsProton sensitivityIntestinalisMost neuronsSynaptic transmissionCionaVertebrates
2005
Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel
Coric T, Zheng D, Gerstein M, Canessa CM. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. The Journal Of Physiology 2005, 568: 725-735. PMID: 16002453, PMCID: PMC1464184, DOI: 10.1113/jphysiol.2005.087734.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion ChannelsAmino Acid SequenceAmino AcidsAnimalsEvolution, MolecularFishesHydrogen-Ion ConcentrationIon Channel GatingMembrane ProteinsMolecular Sequence DataNerve Tissue ProteinsProtein Structure, TertiaryProtonsSequence Homology, Amino AcidSodium ChannelsSpecies SpecificityStructure-Activity RelationshipConceptsAmino acid conservationChanges of residuesProton sensitivityMammalian nervous systemChordate lineageEarly vertebratesFunctional chimerasMammalian counterpartsLower vertebratesAllosteric changesProtein sequencesExtracellular domainSequence analysisDifferent speciesRat sequenceRat channelKinetics of activationStructural determinantsDistinct kineticsVertebratesASIC1 channelsMembrane potentialChimerasSharksEctodomain