2013
Blood pressure hyperreactivity
Kunrath J, Gurzau E, Gurzau A, Goessler W, Gelmann ER, Thach TT, McCarty KM, Yeckel CW. Blood pressure hyperreactivity. Journal Of Hypertension 2013, 31: 361-369. PMID: 23203141, PMCID: PMC3542419, DOI: 10.1097/hjh.0b013e32835c175f.Peer-Reviewed Original ResearchConceptsBlood pressure hyperreactivityBlood pressure recoveryHypertensive responseUnexposed groupMiddle-aged menCold pressor testInorganic arsenic exposureInorganic arsenicCardiovascular stress reactivityNormotensive menBlood pressureEssential hypertensionHypertension riskPressor testHyperreactivityChronic exposureArsenic exposureArsenic-endemic regionEarly signsStress-induced changesFunctional evaluationUrine samplesDrinking waterStress reactivityGreater probability
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallenge
2005
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppression
2004
The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance
Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, Tamborlane WV, Caprio S. The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 747-754. PMID: 15522932, DOI: 10.1210/jc.2004-1258.Peer-Reviewed Original ResearchConceptsBeta-cell responsivenessNormal glucose tolerancePlasma glucose levelsGlucose levelsGlucose toleranceInsulin sensitivityPlasma glucoseObese youthOral glucose tolerance testType 2 diabetes mellitusDecreased insulinogenic indexGlucose tolerance continuumGlucose tolerance testInsulin sensitivity indexContinuum of riskDelta insulinInsulinogenic indexDiabetes mellitusInsulin resistancePlasma levelsTolerance testNormal rangeFunction IndependentDlGlucose concentrationLeg glucose and protein metabolism during an acute bout of resistance exercise in humans
Durham WJ, Miller SL, Yeckel CW, Chinkes DL, Tipton KD, Rasmussen BB, Wolfe RR. Leg glucose and protein metabolism during an acute bout of resistance exercise in humans. Journal Of Applied Physiology 2004, 97: 1379-1386. PMID: 15194677, DOI: 10.1152/japplphysiol.00635.2003.Peer-Reviewed Original ResearchConceptsLeg blood flowResistance exercisePhenylalanine rateLeg glucoseAcute boutBlood flowLactate releaseProtein breakdownWhole-body protein breakdownLower body resistance exerciseGlucose uptakeLeg glucose uptakeLeg lactate releaseBody resistance exerciseVenous blood samplesMuscle protein synthesisProtein metabolismBody protein breakdownExercise regimenExercise boutLeg pressGlutamate uptakeMuscle biopsyProtein synthesisBlood samplesObesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultC-Reactive ProteinChildChild, PreschoolFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesityPostexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise
Sheffield-Moore M, Yeckel CW, Volpi E, Wolf SE, Morio B, Chinkes DL, Paddon-Jones D, Wolfe RR. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. AJP Endocrinology And Metabolism 2004, 287: e513-e522. PMID: 15149953, DOI: 10.1152/ajpendo.00334.2003.Peer-Reviewed Original ResearchConceptsModerate-intensity aerobic exercisePOST-EXFractional synthesis rateAerobic exerciseOlder menYoung menMixed muscle fractional synthesis rateMuscle metabolismRegular aerobic exerciseAcute aerobic exerciseMuscle fractional synthesis rateProtein metabolismArteriovenous blood samplesMuscle protein turnoverSingle boutAcute effectsMuscle biopsyPhenylalanine kineticsBlood samplesPlasma protein synthesisModerate walkingMenShort-term increasePlasma proteinsExerciseValidation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2000
Fat metabolism during high-intensity exercise in endurance-trained and untrained men
Coggan A, Raguso C, Gastaldelli A, Sidossis L, Yeckel C. Fat metabolism during high-intensity exercise in endurance-trained and untrained men. Metabolism 2000, 49: 122-128. PMID: 10647075, DOI: 10.1016/s0026-0495(00)90963-6.Peer-Reviewed Original ResearchConceptsHigh-intensity exerciseFree fatty acidsFatty acid oxidationUntrained menIntramuscular triglyceride storesPlasma FFA fluxEndurance-trained menMinutes of exerciseFatty acidsMaximal oxygen consumptionWhole body rateTotal energy expenditureAcid oxidationFFA fluxFFA utilizationIntense exerciseIndirect calorimetryAdditional fatty acidsAdipose tissueFat metabolismTriglyceride storesRate of appearanceUntrained subjectsEnergy expenditureUntrained individuals
1998
Exogenous amino acids stimulate net muscle protein synthesis in the elderly.
Volpi E, Ferrando A, Yeckel C, Tipton K, Wolfe R. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. Journal Of Clinical Investigation 1998, 101: 2000-2007. PMID: 9576765, PMCID: PMC508787, DOI: 10.1172/jci939.Peer-Reviewed Original ResearchConceptsMuscle protein synthesisAmino acid infusionFractional synthetic rateAmino acid transportAcid infusionMuscle massNet muscle protein synthesisMuscle protein fractional synthetic rateMuscle protein anabolismAcid transportProtein fractional synthetic rateHealthy elderly individualsIntake of proteinAmino acid kineticsAmino acid deliveryAmino acid availabilityAcid availabilityProtein synthesisIntravenous infusionMuscle biopsyElderly individualsProtein anabolismVastus lateralisPostabsorptive stateAmino acid mixture