2022
Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth
Mulligan CJ, Clukay CJ, Matarazzo A, Hadfield K, Nevell L, Dajani R, Panter-Brick C. Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth. PLOS ONE 2022, 17: e0266509. PMID: 35377919, PMCID: PMC8979449, DOI: 10.1371/journal.pone.0266509.Peer-Reviewed Original ResearchConceptsProtective effectTrauma exposureHealth-focused interventionsGenetic variantsDirect protective effectAltered stress reactivityLifetime trauma exposureEarly life adversityPost-traumatic stress symptomsHigh expression variantsOutcome measuresControl studyPsychosocial stressGene x environment interactionsHealth trajectoriesLife adversityMental healthTime pointsWar-related traumaStress reactivityTraumaHigh levelsLongitudinal studyEffects of geneticsPsychosocial environment
2011
Mental Health and Childhood Adversities: A Longitudinal Study in Kabul, Afghanistan
Panter-Brick C, Goodman A, Tol W, Eggerman M. Mental Health and Childhood Adversities: A Longitudinal Study in Kabul, Afghanistan. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 50: 349-363. PMID: 21421175, PMCID: PMC3069303, DOI: 10.1016/j.jaac.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAfghan Campaign 2001-AfghanistanChildCross-Sectional StudiesDepressive DisorderDeveloping CountriesDomestic ViolenceFamily ConflictFemaleHumansLife Change EventsLongitudinal StudiesMaleMental DisordersPersonality AssessmentPsychometricsPsychosocial DeprivationResilience, PsychologicalRisk FactorsSocial EnvironmentSocioeconomic FactorsStress Disorders, Post-TraumaticConceptsPosttraumatic stress symptomsMental health outcomesMental healthSelf-rating scoresHealth outcomesChildhood adversityLifetime traumaStress symptomsKey modifiable factorsPosttraumatic stress symptom scoresMental health problemsStress symptom scoresChild mental healthWar-related stressorsFamily violenceOne-year trajectoriesSymptom scoresModifiable factorsProtective effectDepression scoresWar-affected populationsHealth problemsPosttraumatic stressFamily conflictProspective predictors