2020
GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions
Gerhard DM, Pothula S, Liu RJ, Wu M, Li XY, Girgenti MJ, Taylor SR, Duman CH, Delpire E, Picciotto M, Wohleb ES, Duman RS. GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions. Journal Of Clinical Investigation 2020, 130: 1336-1349. PMID: 31743111, PMCID: PMC7269589, DOI: 10.1172/jci130808.Peer-Reviewed Original ResearchConceptsRapid antidepressant actionsAntidepressant actionGABA interneuronsMedial prefrontal cortexCell-specific knockdownPrinciple neuronsPrefrontal cortexDeletion of GluN2BSingle subanesthetic doseBehavioral actionsAction of ketamineNMDA receptor antagonistExcitatory postsynaptic currentsCellular triggersMajor unmet needKetamine's rapid antidepressant actionsGABA subtypeGluN2B-NMDARsSST interneuronsPostsynaptic currentsReceptor antagonistDepressed patientsSubanesthetic doseExtracellular glutamateMood disorders
1997
Short-latency interneurons in the dorsal nucleus of the little skate, Raja erinacea
Duman C. Short-latency interneurons in the dorsal nucleus of the little skate, Raja erinacea. Brain Research 1997, 771: 80-88. PMID: 9383011, DOI: 10.1016/s0006-8993(97)00859-7.Peer-Reviewed Original ResearchConceptsDorsal nucleusSecond-order cellsCentral nervous system mechanismsHigher spontaneous firing ratesAnimal's own ventilationSpontaneous firing rateSecond-order neuronsNervous system mechanismsPrimary afferentsInhibitory interneuronsRaja erinaceaNeuronal circuitryElectrosensory primary afferentsInterneuronsSuppress responsesFiring rateAfferentsElasmobranch electrosensory systemActivation latencyIntracellular labelingElectrosensory systemSelective suppressionPeripheral zoneLittle skateSimultaneous activation