2019
Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents
Ghosal S, Duman CH, Liu RJ, Wu M, Terwilliger R, Girgenti MJ, Wohleb E, Fogaca MV, Teichman EM, Hare B, Duman RS. Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents. Neurobiology Of Disease 2019, 134: 104669. PMID: 31707118, DOI: 10.1016/j.nbd.2019.104669.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressMedial prefrontal cortexInhibitory post-synaptic currentsGABAergic transmissionSingle doseMale rodentsPrefrontal cortexImbalance of inhibitoryMPFC pyramidal neuronsDepressive-like behaviorDepression-like behaviorStress-induced impairmentModel of depressionPost-synaptic currentsPrecise cellular mechanismsGABAergic proteinsAntidepressant ketamineSynaptic deficitsGABAergic synapsesPyramidal neuronsSynaptic markersGABA markersGlutamate neurotransmissionDepressive behaviorGABA neurotransmission
1997
Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinacea
Duman C, Bodznick D. Distinct but Overlapping Populations of Commissural and GABAergic Neurons in the Dorsal Nucleus of the Little Skate, Raja erinacea. Brain Behavior And Evolution 1997, 49: 99-109. PMID: 9031733, DOI: 10.1159/000112984.Peer-Reviewed Original ResearchConceptsDorsal nucleusCommissural cellsAnimal's own ventilationPrimary afferent fibersCell body areaPrevious electrophysiological studiesGABA-immunoreactiveInhibitory transmitterGABAergic neuronsPrimary afferentsAfferent fibersRetrograde tracerCommissural pathwayImmunohistochemical studyRaja erinaceaStellate cellsElectrophysiological studiesElectrosensory primary afferentsCell groupsMajor efferentsBody areasElectrosensory cellsPeripheral zoneOverlapping populationsLittle skate
1996
A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea
Duman C, Bodznick D. A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea. Journal Of Comparative Physiology A 1996, 179: 797-807. PMID: 8956498, DOI: 10.1007/bf00207358.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionCommon-mode rejection mechanismAnimal's own ventilationReceptor antagonist SR95531Second-order neuronsPrimary afferentsAfferent inputCommissural pathwayContralateral sideDorsal nucleusCommissural cellsSpontaneous activityElectrosensory primary afferentsContralateral inhibitionSR95531Suppress responsesLocal applicationGABAInhibitionElectrosensory stimuliRaja erinaceaElectrosensory processingStimuliResponseAfferents