2014
REDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine 2014, 20: 531-535. PMID: 24728411, PMCID: PMC4016190, DOI: 10.1038/nm.3513.Peer-Reviewed Original Research
2008
Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise
Duman CH, Schlesinger L, Terwilliger R, Russell DS, Newton SS, Duman RS. Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. Behavioural Brain Research 2008, 198: 366-371. PMID: 19056428, PMCID: PMC2729431, DOI: 10.1016/j.bbr.2008.11.016.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorAntidepressant-like behaviorForced-swim testGrowth factorChronic IGF-I treatmentNovelty-induced hypophagia testIGF-I administrationEffects of exerciseIGF-I treatmentAntidepressant effectsHypophagia testNeurotrophic factorNeurotrophic mechanismsStress exposureDepressionFunctional relevanceTreatmentFactorsMiceAdministrationBrain