2015
Spine synapse remodeling in the pathophysiology and treatment of depression
Duman CH, Duman RS. Spine synapse remodeling in the pathophysiology and treatment of depression. Neuroscience Letters 2015, 601: 20-29. PMID: 25582786, PMCID: PMC4497940, DOI: 10.1016/j.neulet.2015.01.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSynaptic protein synthesisPrefrontal cortexSpine densityTreatment-resistant MDD patientsChronic antidepressant treatmentSpine synapse numberControl of moodChronic stress modelSynapse connectivityTreatment of depressionLimbic brain regionsPFC of rodentsRapid therapeutic actionDendrite complexityRegion-specific effectsSynaptogenic hypothesisAntidepressant treatmentAntidepressant ketamineBDNF regulationNeurotrophic factorMDD patientsDepressed patientsSynapse alterationsSynapse numberFunctional abnormalities
2006
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman CH, Schlesinger L, Kodama M, Russell DS, Duman RS. A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment. Biological Psychiatry 2006, 61: 661-670. PMID: 16945347, DOI: 10.1016/j.biopsych.2006.05.047.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAniline CompoundsAnimalsAntidepressive AgentsBehavior, AnimalBenzamidesBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEnzyme InhibitorsHelplessness, LearnedHindlimb SuspensionMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase KinasesMotor ActivitySignal TransductionSwimmingConceptsBrain-derived neurotrophic factorAntidepressant-like effectsAntidepressant treatmentSwim testBDNF heterozygous knockout miceDepressive-like behaviorDepressive-like phenotypeTail suspension testEffects of desipramineHeterozygous knockout miceDepressive behavioral phenotypeEffect of inhibitionRodent behavioral modelsMouse behavioral modelsHeterozygous gene deletionAntidepressant mechanismAcute administrationAcute blockadeNeurotrophic factorAntidepressant drugsSuspension testDepressive phenotypeKnockout miceMEK inhibitionMEK inhibitors
2005
Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity
Duman C, Duman R. Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity. Handbook Of Experimental Pharmacology 2005, 169: 305-334. PMID: 16594263, DOI: 10.1007/3-540-28082-0_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCAMP response element-binding proteinSignaling pathwaysAdditional signaling pathwaysIntracellular signaling pathwaysResponse element-binding proteinElement-binding proteinTreatment of anxietyNeuronal plasticitySignal transductionAnxiolytic effectivenessChronic antidepressant actionBinding proteinCellular mechanismsChronic antidepressant treatmentFunctional plasticityImportance of mechanismsPathophysiology of anxietyPathwayPlasticityProteinAntidepressant treatmentAntidepressant actionFunctional outcomeMolecular alterationsTreatment strategies