2024
The Impact of Diabetes Mellitus on the Outcomes of Revascularization for Chronic Limb-Threatening Ischemia in the BEST-CLI trial
Ochoa Chaar C, Malas M, Doros G, Schermerhorn M, Conte M, Alameddine D, Siracuse J, Yadavalli S, Dake M, Creager M, Tan T, Rosenfield K, Menard M, Farber A, Hamdan A. The Impact of Diabetes Mellitus on the Outcomes of Revascularization for Chronic Limb-Threatening Ischemia in the BEST-CLI trial. Journal Of Vascular Surgery 2024 PMID: 39332785, DOI: 10.1016/j.jvs.2024.09.026.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAnkle amputationLower extremity revascularizationBEST-CLI trialBEST-CLILimb-threatening ischemiaAll-cause deathDiabetes mellitusChronic obstructive pulmonary diseaseImpact of diabetes mellitusImpact of DMObstructive pulmonary diseasePotential confoundersBest Surgical TherapyAnkleAdverse limb eventsToe pressureBest EndovascularAnkle pressureRenal diseaseAmputationObservational studyOptimal medical therapyOutcomes of patientsCompared to patientsIntravascular Ultrasound Use is Associated with Improved Patency in Lower Extremity Peripheral Arterial Interventions
Brahmandam A, Kim T, Parziale S, Deng Y, Setia O, Tonnessen B, Ochoa Chaar C, Guzman R, Aboian E. Intravascular Ultrasound Use is Associated with Improved Patency in Lower Extremity Peripheral Arterial Interventions. Annals Of Vascular Surgery 2024, 106: 410-418. PMID: 38810722, DOI: 10.1016/j.avsg.2024.03.008.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaChronic limb threatening ischemia patientsGeneralized estimating equationsPeripheral vascular interventionsPeripheral arterial diseaseAssociated with improved patencyPredictors of 1-year outcomeIntravascular ultrasound useVascular Quality InitiativeSubgroup analysisAdjunctive useD lesionsTASC CPropensity matchingTreatment modalitiesTrans-Atlantic Inter-Society Consensus (TASC) classificationMajor amputationLimb-threatening ischemiaBalloon angioplastyIntravascular ultrasoundImproved patencyUltrasound useOne-year followQuality InitiativePredictors of patencyInsulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease
Alameddine D, Satam K, Slade M, Wang H, Mena-Hurtado C, Turner J, Inzucchi S, Ochoa Chaar C. Insulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease. Annals Of Vascular Surgery 2024, 102: 25-34. PMID: 38307234, DOI: 10.1016/j.avsg.2023.11.044.Peer-Reviewed Original ResearchInsulin-requiring diabetes mellitusPeripheral arterial diseaseDiabetes mellitusInfrainguinal bypassInsulin requirementsArtery diseaseRisk of MALEBypass surgeryImpact of insulin useRates of primary patencyVascular Quality Initiative databaseOutcomes of patientsPeripheral arterial bypass surgeryInfrainguinal bypass surgeryStratification of patientsCrude rateElevated hemoglobin A1cArtery bypass surgeryAssociation of DMChronic limb-threatening ischemiaIncreased risk of MALEVascular Quality InitiativeLower extremity revascularizationAdverse limb eventsLimb-threatening ischemia
2023
The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Zhuo H, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization. Annals Of Vascular Surgery 2023, 98: 210-219. PMID: 37802138, DOI: 10.1016/j.avsg.2023.08.009.Peer-Reviewed Original ResearchMajor adverse limb eventsReduced ejection fractionLower extremity revascularizationPeripheral arterial diseaseMALE-free survivalAdverse limb eventsCoronary artery diseaseEjection fractionExtremity revascularizationArtery diseaseLimb eventsChronic limb-threatening ischemiaLimb-threatening ischemiaTricuspid valve regurgitationKaplan-Meier curvesElectronic medical recordsMajor amputationSevere mitralDiastolic dysfunctionEchocardiographic findingsTransthoracic echocardiogramHeart failureValve regurgitationArterial diseaseSingle centerPerioperative complications following open or endovascular revascularization for chronic limb-threatening ischemia in the BEST-CLI Trial
Siracuse J, Farber A, Menard M, Conte M, Kaufman J, Jaff M, Kiang S, Ochoa Chaar C, Osborne N, Singh N, Tan T, Guzman R, Strong M, Hamza T, Doros G, Rosenfield K. Perioperative complications following open or endovascular revascularization for chronic limb-threatening ischemia in the BEST-CLI Trial. Journal Of Vascular Surgery 2023, 78: 1012-1020.e2. PMID: 37318428, DOI: 10.1016/j.jvs.2023.05.040.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaSingle-segment great saphenous veinLimb-threatening ischemiaRisk-adjusted analysisCohort 2Cohort 1BEST-CLICardiovascular eventsEndovascular revascularizationPerioperative complicationsRevascularization strategyLower extremity bypass surgeryMajor adverse cardiovascular eventsBest Surgical TherapyBEST-CLI trialPeri-procedure complicationsAdverse cardiovascular eventsPeri-procedural complicationsThirty-day mortalityAcute renal failureGreat saphenous veinEndovascular revascularization strategiesBest EndovascularPerioperative morbidityBypass surgery
2020
Multiple Reinterventions for Claudication are Associated with Progression to Chronic Limb-Threatening Ischemia
Kim TI, Kiwan G, Mohamedali A, Zhang Y, Dardik A, Guzman RJ, Ochoa Chaar CI. Multiple Reinterventions for Claudication are Associated with Progression to Chronic Limb-Threatening Ischemia. Annals Of Vascular Surgery 2020, 72: 166-174. PMID: 33227462, DOI: 10.1016/j.avsg.2020.10.004.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity revascularizationCongestive heart failureHeart failureOpen revascularizationMultiple reinterventionsSingle-center retrospective reviewChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaNumber of reinterventionsLong-term outcomesMultivariable logistic regressionRate of progressionBenign natural historyIndex revascularizationMajor amputationRest painPerioperative complicationsExtremity revascularizationRetrospective reviewRisk factorsDisease progressionOpen procedureClaudicationLower Extremity Revascularization for Chronic Limb-Threatening Ischemia among Patients at the Extremes of Age
Kim TI, Aboian E, Fischer U, Zhang Y, Guzman RJ, Ochoa Chaar CI. Lower Extremity Revascularization for Chronic Limb-Threatening Ischemia among Patients at the Extremes of Age. Annals Of Vascular Surgery 2020, 72: 517-528. PMID: 32927042, DOI: 10.1016/j.avsg.2020.08.135.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetAgedAged, 80 and overAgingAmputation, SurgicalChronic DiseaseDatabases, FactualEndovascular ProceduresFemaleHumansIschemiaLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseaseRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaLower extremity revascularizationExtremes of ageRisk factor profileMajor amputationPatients 51Extremity revascularizationFactor profileDistinct risk factor profilesAge groupsChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaMajor amputation ratePeripheral artery diseaseGroup of patientsInsulin-dependent diabetesExtreme age groupsSuprainguinal bypassAmputation rateElderly patientsInfrainguinal bypassActive smokersArtery diseaseMultivariable analysis