2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2012
Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers
De Vries TT, Bello D, Stowe MH, Harari H, Slade MD, Redlich CA. Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers. Journal Of Occupational And Environmental Hygiene 2012, 9: 699-711. PMID: 23067057, DOI: 10.1080/15459624.2012.728893.Peer-Reviewed Original ResearchConceptsSkin exposureSkin samplesAuto body shop workersOccupational asthmaIsocyanate asthmaCommon causeSkin wipesGreater riskSkin contactPotent sensitizerInitial sampling timeShop workersPositive samplesAsthmaAuto body shopsHigh-performance liquid chromatographyExposureCross-linking chemicalsRiskGeometric meanLiquid chromatography
2008
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm
Liu Y, Stowe MH, Bello D, Sparer J, Gore RJ, Cullen MR, Redlich CA, Woskie SR. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: III. A Personal Exposure Algorithm. Annals Of Work Exposures And Health 2008, 53: 33-40. PMID: 19011126, PMCID: PMC2638551, DOI: 10.1093/annhyg/men070.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure metricsAuto body shop workersExposure indexUse of PPEExposure-response relationshipJob title categoriesAuto Body RepairIsocyanate asthmaExposure algorithmSemiquantitative algorithmSkin areasProtective equipmentSuch exposureExposure dataSpearman correlationShop workersExposure indicatorsOffice workersPositive Spearman correlationAuto body shopsExposureTask-based dataWork diariesLung/skin connections in occupational lung disease
Redlich C, Herrick C. Lung/skin connections in occupational lung disease. Current Opinion In Internal Medicine 2008, 7: 215-219. DOI: 10.1097/mci.0b013e328303e3cb.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergensLung/skin connections in occupational lung disease
Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Current Opinion In Allergy And Clinical Immunology 2008, 8: 115-119. PMID: 18317018, DOI: 10.1097/aci.0b013e3282f85a31.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergens
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidence
1999
The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight Asthma
Redlich C, Cain H, Wisnewski A. The Immunology and Prevention of Isocyanate Asthma: A Model for Low Molecular Weight Asthma. Seminars In Respiratory And Critical Care Medicine 1999, 20: 591-599. DOI: 10.1055/s-2007-1009478.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1997
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.
Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.Peer-Reviewed Original ResearchConceptsHuman bronchial biopsiesHuman lung tissueExposure-disease relationshipsAirway eosinophilsAirway histologyEpithelial exposureMethacholine challengeBronchial biopsiesEndobronchial biopsyInflammatory changesClinical featuresAirway biopsiesIsocyanate asthmaLung tissueT cellsImmunohistochemical stainingAsthmaBiopsyExposure patternsBronchoscopyExposureAirwayPatientsEosinophilsHistology