2018
Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder
Husky MM, Mazure CM, Kovess-Masfety V. Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder. Comprehensive Psychiatry 2018, 84: 75-81. PMID: 29723769, DOI: 10.1016/j.comppsych.2018.04.007.Peer-Reviewed Original ResearchConceptsSevere post-traumatic stress disorderPost-traumatic stress disorderMedical conditionsPsychiatric disordersComposite International Diagnostic Interview Short FormStress disorderComorbid psychiatric disordersCross-sectional general population surveySubstance use disordersGender-specific differencesGeneral population surveyMedical comorbiditiesMedical morbiditySevere headacheComorbid depressionSocietal burdenGeneral populationSevere casesUse disordersGreater oddsGender differencesNeck problemsPTSD diagnosisPTSD sufferersAnxiety disorders
2016
β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey-Smith S, Martins RN, Salvado O, Dore V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Maruff P, Pietrzak RH, Australian Imaging B. β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal Of Geriatric Psychiatry 2016, 24: 1191-1195. PMID: 27742526, DOI: 10.1016/j.jagp.2016.08.007.Peer-Reviewed Original ResearchConceptsBDNF genotypeNormal older womenAnxiety symptomsOlder adultsΕ4 carriageOlder womenDepressive symptomsΒ-amyloidGreater severityAustralian Imaging BiomarkersNon-ε4 carriersSeverity of depressiveMet allele carriersSeverity of anxietyGreater depressive symptomsNormal older adultsGreater anxiety symptomsLifestyle StudyΕ4 carriersAPOE genotypeAllele carriersAnalysis of covarianceImaging biomarkersSymptomsDepressive
2010
Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch
Epperson CN, Toll B, Wu R, Amin Z, Czarkowski KA, Jatlow P, Mazure CM, O’Malley S. Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch. Drug And Alcohol Dependence 2010, 112: 1-8. PMID: 20561758, PMCID: PMC2946976, DOI: 10.1016/j.drugalcdep.2010.04.021.Peer-Reviewed Original ResearchConceptsPlacebo groupStudy completersNaltrexone doseClinical trialsContinuous abstinenceOral naltrexone treatmentNicotine patch therapyNicotine replacement therapyInteractive voice responseRandomized clinical trialsMenstrual cycle statusEffect of doseNaltrexone augmentationNaltrexone groupAdverse eventsNaltrexone treatmentNicotine patchPatch therapyReplacement therapyQuit dayWeek 1AbstinenceDoseWomenLess adherent
2003
A model of risk for major depression: Effects of life stress and cognitive style vary by age
Mazure CM, Maciejewski PK. A model of risk for major depression: Effects of life stress and cognitive style vary by age. Depression And Anxiety 2003, 17: 26-33. PMID: 12577275, DOI: 10.1002/da.10081.Peer-Reviewed Original ResearchConceptsCognitive styleElderly adultsStable risk factorsStress-diathesis modelModel of riskAdverse life eventsAge-specific perspectiveMajor depressionLife eventsPersonal vulnerabilityLife stressEvent typesAge-specific approachesEvidence-based modelYoung adultsIndependent samplesRisk of depressionStyleDepressionHigh needAdultsPrior workEmpirical studySociotropyAdverse event types
2002
Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression
Mazure CM, Maciejewski PK, Jacobs SC, Bruce ML. Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression. American Journal Of Geriatric Psychiatry 2002, 10: 297-304. PMID: 11994217, DOI: 10.1097/00019442-200205000-00009.Peer-Reviewed Original ResearchConceptsPersonality stylesCognitive theoryBeck's cognitive theoryStressful life eventsLife eventsLife stressorsYears of educationMajor depressionDepression onsetUnipolar major depressionOnset major depressionDepressionStyleLate-onset depressionPositive associationPhysical functioningFunctioningStressorsMedical illnessControl subjectsCurrent workMultivariate modelElderly outpatientsTheory
1998
Acute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeuroleptics
1995
Desipramine Treatment of Major Depression in Patients Over 75 Years of Age
Nelson J, Mazure C, Jatlow P. Desipramine Treatment of Major Depression in Patients Over 75 Years of Age. Journal Of Clinical Psychopharmacology 1995, 15: 99-105.. PMID: 7782495, DOI: 10.1097/00004714-199504000-00004.Peer-Reviewed Original ResearchConceptsYounger patientsYears of ageElderly patientsMajor depressionDesipramine concentrationsDrug treatmentPatient trialsAdverse reaction rateMore effective drug treatmentsEffective drug treatmentUnipolar major depressionDesipramine treatmentDepressed patientsComparable dosesPatientsSide effectsResponse rateSimilar durationTrialsSecond trialTreatmentLower ratesBloodDepressionAge
1989
Depression in late life: age of onset as marker of a subtype
Conwell Y, Nelson J, Kim K, Mazure C. Depression in late life: age of onset as marker of a subtype. Journal Of Affective Disorders 1989, 17: 189-195. PMID: 2527894, DOI: 10.1016/0165-0327(89)90042-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgedAged, 80 and overDementiaDepressive DisorderElectroencephalographyFemaleHumansMaleMiddle AgedTomography, X-Ray ComputedConceptsAge of onsetLate-onset depressionElderly depressivesEarly-onset illnessLonger hospital stayRecurrent affective disordersDistinct pathological processesMore residual symptomsUnipolar major depressivesPresence of psychosisHospital stayClinical featuresMedical illnessResidual symptomsAffective illnessFamily historyLower incidenceMajor depressiveAffective disordersSymptom severityIllnessPathological processesDepressiveLater lifeAgeElderly Patients Admitted to the Psychiatric Unit of a General Hospital
Conwell Y, Nelson JC, Kim K, Mazure CM. Elderly Patients Admitted to the Psychiatric Unit of a General Hospital. Journal Of The American Geriatrics Society 1989, 37: 35-41. PMID: 2909603, DOI: 10.1111/j.1532-5415.1989.tb01566.x.Peer-Reviewed Original ResearchConceptsElderly psychiatric patientsPsychiatric patientsGeneral hospital psychiatric settingLength of stayAcute inpatient settingsDiagnosis of dementiaInpatient psychiatry unitTerms of demographicsHospital courseElderly patientsClinical profileCommon diagnosisDepressive illnessShorter hospitalizationPatient populationPrimary diagnosisGeneral HospitalInpatient settingOutcome measuresPsychiatric unitPatientsPsychiatric settingsPsychiatry unitFavorable responseMental illness
1987
Plasma catecholamine metabolites in subtypes of major depression
Mazure C, Bowers M, Hoffman F, Miller K, Nelson J. Plasma catecholamine metabolites in subtypes of major depression. Biological Psychiatry 1987, 22: 1469-1472. PMID: 3676373, DOI: 10.1016/0006-3223(87)90105-3.Peer-Reviewed Original Research