2022
Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainChildChild AbuseFemaleGray MatterHumansMagnetic Resonance ImagingMalePrefrontal CortexConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverity
2016
Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents
Lippard ET, Mazure CM, Johnston JA, Spencer L, Weathers J, Pittman B, Wang F, Blumberg HP. Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents. Journal Of Neuroscience Research 2016, 95: 777-791. PMID: 27870392, PMCID: PMC5123602, DOI: 10.1002/jnr.23901.Peer-Reviewed Original ResearchConceptsGray matter volumePrefrontal gray matter volumeBipolar disorderSubstance use problemsFuture substance useSubstance useLower gray matter volumeUse problemsFuture substance use problemsRegional gray matter volumeStructural magnetic resonanceAdverse outcomesTemporopolar cortexInsula gray matter volumeSubstance exposureMood disordersHigh riskLower riskSubsequent alcoholMatter volumeNeurodevelopmental basisSubstance problemsDisordersAdolescentsMales
2003
Discontinuation of Antidepressants in Newly Admitted Psychotic Patients
Bowers MB, McKay BG, Mazure CM. Discontinuation of Antidepressants in Newly Admitted Psychotic Patients. Journal Of Neuropsychiatry 2003, 15: 227-230. PMID: 12724466, DOI: 10.1176/jnp.15.2.227.Peer-Reviewed Original Research
2002
Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis
Fortunati F, Mazure C, Preda A, Wahl R, Bowers M. Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis. Journal Of Affective Disorders 2002, 68: 331-334. PMID: 12063160, DOI: 10.1016/s0165-0327(00)00327-x.Peer-Reviewed Original Research
2001
Cortical instability and the mechanism of mania: a neural network simulation and perceptual test
Hoffman R, Quinlan D, Mazure C, McGlashan T. Cortical instability and the mechanism of mania: a neural network simulation and perceptual test. Biological Psychiatry 2001, 49: 500-509. PMID: 11257235, DOI: 10.1016/s0006-3223(00)01071-4.Peer-Reviewed Original ResearchConceptsCognitive speedNeural representationNeural network simulationAuditory continuous performance taskNecker cube perceptionContinuous performance taskSimple perceptual tasksPerceptual tasksPerceptual testsPerformance taskNecker cubeCube taskHuman subject studiesReversal rateCortical noiseSubject studyIndiscriminate responseNormal control subjectsStick figuresTaskSchizophreniaRepresentationNeural networkControl subjectsStimuliAntidepressant-associated mania and psychosis resulting in psychiatric admissions.
Preda A, MacLean RW, Mazure CM, Bowers MB. Antidepressant-associated mania and psychosis resulting in psychiatric admissions. The Journal Of Clinical Psychiatry 2001, 62: 30-3. PMID: 11235925, DOI: 10.4088/jcp.v62n0107.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGeneral hospital psychiatric unitAntidepressant-associated maniaNewer atypical agentsSide effect profileSerotonin reuptake inhibitorsHospital psychiatric unitRate of admissionAdverse behavioral effectsAntidepressant useReuptake inhibitorsEffect profileAtypical agentsPsychiatric admissionsAntidepressant drugsPsychiatric unitBehavioral effectsAdverse behavioral reactionsAdmissionSignificant increasePsychosisManiaDrugsTolerabilityAntidepressants
1999
Lamotrigine as prophylaxis against steroid-induced mania.
Preda A, Fazeli A, McKay B, Bowers M, Mazure C. Lamotrigine as prophylaxis against steroid-induced mania. The Journal Of Clinical Psychiatry 1999, 60: 708-9. PMID: 10549692, DOI: 10.4088/jcp.v60n1017.Peer-Reviewed Original ResearchDrug-Responsive Mania in a Man With a Brain Tumor
Mazure C, Leibowitz K, Bowers M. Drug-Responsive Mania in a Man With a Brain Tumor. Journal Of Neuropsychiatry 1999, 11: 114-115. PMID: 9990567, DOI: 10.1176/jnp.11.1.114.Peer-Reviewed Original Research
1998
Pretreatment plasma HVA predicts neuroleptic response in manic psychosis
Mazure C, Bowers M. Pretreatment plasma HVA predicts neuroleptic response in manic psychosis. Journal Of Affective Disorders 1998, 48: 83-86. PMID: 9495606, DOI: 10.1016/s0165-0327(97)00159-6.Peer-Reviewed Original Research
1997
Chronic neuroleptic exposure in bipolar outpatients.
Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW. Chronic neuroleptic exposure in bipolar outpatients. The Journal Of Clinical Psychiatry 1997, 58: 193-5. PMID: 9184612, DOI: 10.4088/jcp.v58n0503.Peer-Reviewed Original ResearchConceptsChronic neuroleptic exposureNeuroleptic exposureBipolar outpatientsBipolar disorderConnecticut Mental Health CenterChronic neuroleptic administrationMental health centersComputerized administrative databasesNeuroleptic medicationChlorpromazine equivalentsNeuroleptic administrationChronic useMedical recordsAdministrative databasesNeuroleptic dosageHealth centersBipolar patientsPatientsOutpatientsReview criteriaDisordersExposurePast yearMedicationsDiagnosisThe differential diagnosis of multiple sclerosis and bipolar disorder.
Young C, Weiss E, Bowers M, Mazure C. The differential diagnosis of multiple sclerosis and bipolar disorder. The Journal Of Clinical Psychiatry 1997, 58: 123. PMID: 9108815, DOI: 10.4088/jcp.v58n0307a.Peer-Reviewed Original Research
1995
DSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity
Mazure CM, Kincare P, Schaffer CE. DSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity. Psychiatry 1995, 58: 56-64. PMID: 7792323, DOI: 10.1080/00332747.1995.11024711.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAgedBipolar DisorderDementiaDepressive DisorderFemaleHumansMaleMiddle AgedPatient AdmissionPersonality AssessmentPsychiatric Status Rating ScalesPsychometricsPsychotic DisordersReproducibility of ResultsRisk FactorsSchizophreniaSchizophrenic PsychologySomatoform DisordersStress, PsychologicalConceptsPsychosocial stressorsAxis IVClinical setting todayMultiaxial diagnostic systemImportant precipitantsExacerbation of psychopathologyPatient reportsPatients' appraisalPsychiatric disordersClinical ratingsClinician reliabilityObjective ratingsSeverityExacerbationStressor severityNosological systemsReportStressorsSubjective appraisalClinicians
1992
Lithium in combination with perphenazine: effect on plasma monoamine metabolites
Bowers M, Mazure C, Nelson J, Jatlow P. Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biological Psychiatry 1992, 32: 1102-1107. PMID: 1477190, DOI: 10.1016/0006-3223(92)90190-b.Peer-Reviewed Original ResearchDrug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis
Mazure C, Nelson J, Jatlow P, Bowers M. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biological Psychiatry 1991, 30: 475-482. PMID: 1932395, DOI: 10.1016/0006-3223(91)90309-a.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultBipolar DisorderChromatography, High Pressure LiquidDepressive DisorderDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPerphenazinePrognosisProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPlasma homovanillic acidHomovanillic acidFree homovanillic acidClinical responseEarly clinical responsePlasma-free homovanillic acidUseful clinical predictorClinical predictorsNeuroleptic treatmentAcute psychosisDopamine metabolismNoradrenergic functioningMethoxyhydroxyphenylglycolFavorable responsePsychotic inpatientsGood responseSignificant decline
1990
Psychotogenic Drug Use and Neuroleptic Response
Bowers MB, Mazure CM, Nelson JC, Jatlow PI. Psychotogenic Drug Use and Neuroleptic Response. Schizophrenia Bulletin 1990, 16: 81-85. PMID: 1970670, DOI: 10.1093/schbul/16.1.81.Peer-Reviewed Original ResearchConceptsDrug useNeuroleptic responseDual diagnosis patientsDoses of haloperidolPsychotic malesDevelopment of psychosisPsychotogenic drugsDiagnosis patientsDopaminergic mechanismsPrior historyPsychotic disordersMeans of effectsRefractorinessSeparate studiesMalesEarly stagesHaloperidolPatientsIllnessPsychosisDoses