2020
Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia
Steele A, Gonzalez R, Garbalosa JC, Steigbigel K, Grgurich T, Parisi EJ, Feinn RS, Tommasini SM, Macica CM. Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa064. PMID: 32047911, PMCID: PMC8416779, DOI: 10.1210/clinem/dgaa064.Peer-Reviewed Original ResearchConceptsMusculoskeletal comorbiditiesGait analysisPassive ROMLifelong metabolic diseaseWeight-bearing jointsHealth care teamDiagnosis of XLHInterprofessional health care teamsKinematic gait analysisMusculoskeletal manifestationsClinical presentationMusculoskeletal disabilityDegenerative arthritisPhysical functionRadiologic imagingCervical spineGoniometric rangeDaily livingFunctional limitationsTrunk swayMetabolic diseasesMusculoskeletal functionAnkle jointSynovial jointsXLH
2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2012
Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice
Karaplis A, Bai X, Falet J, Macica C. Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice. Endocrinology 2012, 153: 5906-5917. PMID: 23038738, PMCID: PMC3512070, DOI: 10.1210/en.2012-1551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracellular Matrix ProteinsFamilial Hypophosphatemic RicketsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenetic Diseases, X-LinkedImmunohistochemistryKidneyMaleMiceMice, Inbred C57BLMice, TransgenicModels, GeneticMutationPedigreePhosphatesPhosphoproteinsRheumatic DiseasesTransgenesUp-RegulationConceptsPhosphate-wasting disordersStandard therapyFGF23 levelsElevated fibroblast growth factor 23Hyp miceRenal phosphate-wasting disordersFibroblast growth factor 23High FGF23 levelsGrowth factor 23Elevated FGF23 levelsAction of FGF23Dentin matrix acidic phosphoprotein 1Phosphate wasting disorderAutosomal recessive hypophosphatemic ricketsRecessive hypophosphatemic ricketsLigament insertion sitesChildhood managementOral phosphateFactor 23Achilles insertionDisease morbidityPotential morbidityBone spursUntoward effectsMurine model
2011
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model
Macica C, Liang G, Nasiri A, Broadus AE. Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis & Rheumatism 2011, 63: 3333-3343. PMID: 21702022, PMCID: PMC3197958, DOI: 10.1002/art.30515.Peer-Reviewed Original ResearchConceptsHormone-related proteinDegenerative changesKO miceParathyroid hormone-related proteinMale KO miceExperimental mouse modelMouse articular cartilageTotal histologic scoreIndian hedgehogTibial articular surfaceArticular chondrocytesArticular cartilageGrowth differentiation factor 5Degenerative findingsControl miceHistologic scoresMouse modelCompensatory increaseTime-course studyDifferentiation factor 5PTHrPRegulatory roleMiceConditional deletionChondrocyte maintenance
1994
TNF production by the medullary thick ascending limb of Henle's loop
Macica C, Escalante B, Conners M, Ferreri N. TNF production by the medullary thick ascending limb of Henle's loop. Kidney International 1994, 46: 113-121. PMID: 7933828, DOI: 10.1038/ki.1994.250.Peer-Reviewed Original Research
1993
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine
Macica C, Balazy M, Falck J, Mioskowski C, Carroll M. Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine. American Journal Of Physiology 1993, 265: g735-g741. PMID: 8238357, DOI: 10.1152/ajpgi.1993.265.4.g735.Peer-Reviewed Original ResearchConceptsEpithelial ion transportAA metabolitesNew Zealand white male rabbitsRegional blood flowArachidonic acid metabolismWhite male rabbitsDuodenal microsomesIleal microsomesMesenteric bedIntestinal functionArachidonate metabolismBW 755CBlood flowHigh-pressure liquid chromatographyEnzyme inhibitorsMale rabbitsAA metabolismIntestinal tractSKF-525ALipoxygenase inhibitorsRabbit intestineMicrosomal activityPresence of NADPHAbsence of NADPHAcid metabolism
1992
Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats
Wilkes B, Kaplan R, Mento P, Aynedjian H, Macica C, Schlondorff D, Bank N. Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats. Kidney International 1992, 41: 992-999. PMID: 1387436, DOI: 10.1038/ki.1992.151.Peer-Reviewed Original ResearchConceptsRenal blood flowGlomerular filtration rateDiabetic ratsThromboxane receptorFiltration rateBlood flowNormal controlsReceptor sitesHigher renal blood flowEuglycemic diabetic ratsHyperglycemic diabetic ratsRenal hemodynamic responseStable thromboxane analogThromboxane synthetase inhibitionUrinary thromboxane excretionInjection of streptozotocinAngiotensin II receptorsThromboxane excretionVasoconstrictor responsesConstrictor responsesDiabetic kidneyEarly diabetesVasoconstrictor receptorsBlood glucoseRats 7
1991
Localization of endothelin-like immunoreactivity in rat kidneys
Wilkes B, Susin M, Mento P, Macica C, Girardi E, Boss E, Nord E. Localization of endothelin-like immunoreactivity in rat kidneys. American Journal Of Physiology 1991, 260: f913-f920. PMID: 2058711, DOI: 10.1152/ajprenal.1991.260.6.f913.Peer-Reviewed Original ResearchConceptsEndothelin-like immunoreactivityVasa rectaeEndothelin-1Renal papillaRat kidneyProximal tubule brush borderDistal nephron segmentsTubule brush borderNormal rat kidneyGlomerular immunostainingArcuate arteriesPeritubular capillariesRenal cortexRenal tissueImmunoperoxidase techniqueParacrine actionIntense immunostainingCytoplasmic immunostainingDuct epitheliumImmunostaining densityRenal medullaBig endothelinNephron segmentsImmunoreactivityImmunostainingGlomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats
Wilkes B, Pearl A, Mento P, Maita M, Macica C, Girardi E. Glomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats. American Journal Of Physiology 1991, 260: f110-f118. PMID: 1847009, DOI: 10.1152/ajprenal.1991.260.1.f110.Peer-Reviewed Original ResearchConceptsIschemic acute renal failureAcute renal failureRenal blood flowGlomerular filtration rateET receptorsRenal failureEndothelin receptorsET infusionElevated ET levelsLeft renal arteryMean arterial pressureNormal Sprague-Dawley ratsSprague-Dawley ratsReceptor sitesRenal hemodynamicsArterial pressureContralateral kidneyRenal arteryFiltration rateReceptor numberBlood flowET levelsRatsET bindingAdditional studies