Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats
Wilkes B, Kaplan R, Mento P, Aynedjian H, Macica C, Schlondorff D, Bank N. Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats. Kidney International 1992, 41: 992-999. PMID: 1387436, DOI: 10.1038/ki.1992.151.Peer-Reviewed Original ResearchConceptsRenal blood flowGlomerular filtration rateDiabetic ratsThromboxane receptorFiltration rateBlood flowNormal controlsReceptor sitesHigher renal blood flowEuglycemic diabetic ratsHyperglycemic diabetic ratsRenal hemodynamic responseStable thromboxane analogThromboxane synthetase inhibitionUrinary thromboxane excretionInjection of streptozotocinAngiotensin II receptorsThromboxane excretionVasoconstrictor responsesConstrictor responsesDiabetic kidneyEarly diabetesVasoconstrictor receptorsBlood glucoseRats 7