IGF‐1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination
Liang G, Cline GW, Macica CM. IGF‐1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination. Glia 2007, 55: 632-641. PMID: 17299765, DOI: 10.1002/glia.20496.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsCell CommunicationCells, CulturedCoculture TechniquesFatty AcidsGanglia, SpinalInsulin-Like Growth Factor IMembrane LipidsMyelin SheathNeurons, AfferentPeripheral Nervous SystemPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySchwann CellsSignal TransductionConceptsInsulin-like growth factor-1Fatty acid synthesizing enzymesSynthesizing enzymesIGF-1 treatmentMyelin membrane formationGrowth factor-1PI3K/Akt pathwaySchwann cell differentiationPI3K/AktWestern blot analysisSciatic nerveIGF-1Schwann cellsElectrospray mass spectroscopy analysisCell coculturesMyelin-specific proteinsGrowth factorAkt pathwayMyelinationFactor 1Fatty acid synthesisCocultureBlot analysisEarly eventsMyelin membrane