2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2011
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model
Macica C, Liang G, Nasiri A, Broadus AE. Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis & Rheumatism 2011, 63: 3333-3343. PMID: 21702022, PMCID: PMC3197958, DOI: 10.1002/art.30515.Peer-Reviewed Original ResearchConceptsHormone-related proteinDegenerative changesKO miceParathyroid hormone-related proteinMale KO miceExperimental mouse modelMouse articular cartilageTotal histologic scoreIndian hedgehogTibial articular surfaceArticular chondrocytesArticular cartilageGrowth differentiation factor 5Degenerative findingsControl miceHistologic scoresMouse modelCompensatory increaseTime-course studyDifferentiation factor 5PTHrPRegulatory roleMiceConditional deletionChondrocyte maintenance