2009
Survey of the Enthesopathy of X-Linked Hypophosphatemia and Its Characterization in Hyp Mice
Liang G, Katz LD, Insogna KL, Carpenter TO, Macica CM. Survey of the Enthesopathy of X-Linked Hypophosphatemia and Its Characterization in Hyp Mice. Calcified Tissue International 2009, 85: 235-246. PMID: 19609735, PMCID: PMC2988401, DOI: 10.1007/s00223-009-9270-6.Peer-Reviewed Original ResearchMeSH KeywordsAchilles TendonAdolescentAdultAgedAnimalsBiomarkersCalcinosisChildDisease Models, AnimalDisease ProgressionFamilial Hypophosphatemic RicketsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenetic Diseases, X-LinkedHumansMiceMice, Inbred C57BLMiddle AgedPatellar LigamentPhenotypeQuadriceps MuscleRadiographyRheumatic DiseasesTendinopathyTendonsYoung AdultConceptsFGF-23Fibroblast growth factor receptor 3Hyp miceMajority of patientsHigh circulating levelsPhosphate-regulating hormoneBone spur formationTendon insertion siteGrowth factor receptor 3Insertion siteLigament insertion sitesCirculating LevelsPhosphate excretionBone-forming osteoblastsHeterotopic calcificationOsteophyte formationHistological examinationMurine modelReceptor 3Spur formationHypophosphatemiaEnthesis fibrocartilageBone mineralizationBiochemical milieuMice
2007
The PTHrP Functional Domain Is at the Gates of Endochondral Bones
BROADUS AE, MACICA C, CHEN X. The PTHrP Functional Domain Is at the Gates of Endochondral Bones. Annals Of The New York Academy Of Sciences 2007, 1116: 65-81. PMID: 18083922, DOI: 10.1196/annals.1402.061.Peer-Reviewed Original ResearchConceptsGene expression productsEndochondral boneGene regulation experimentsFunctional domainsBone cell populationsMesenchymal condensationLow abundanceChondrocyte populationsKnockin miceCell populationsGrowth plate cartilageUnrecognized siteInsertion siteExpressionEpiphyseal cartilageSitesLacZAbundanceMechanical regulation of PTHrP expression in entheses
Chen X, Macica C, Nasiri A, Judex S, Broadus AE. Mechanical regulation of PTHrP expression in entheses. Bone 2007, 41: 752-759. PMID: 17869201, PMCID: PMC2219696, DOI: 10.1016/j.bone.2007.07.020.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentPTHrP expressionSurgical transectionBone cell populationsTail suspensionType 1 PTH/PTHrP receptorCell populationsPTH/PTHrP receptorDetailed histological evaluationSitu hybridization histochemical techniquesDistinct temporospatial patternLigament insertion sitesMetaphyseal periosteumPTHrP receptorOsteoclastic activityCollateral ligamentHistological evaluationReporter miceKnockin miceInsertion siteKnockin reporter micePTHrPPTHrP geneCD-1Periosteum