Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O’Brien P, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature Communications 2015, 6: 5998. PMID: 25601659, PMCID: PMC4454288, DOI: 10.1038/ncomms6998.Peer-Reviewed Original ResearchConceptsF-AuNPsNon-polar moleculesTeflon-like coatingDesorption/ionizationFluorinated nanoparticlesGold nanoparticlesMass spectrometry imagingAnalyte desorptionRemarkable biocompatibilityMass spectrometry analysisElectron microscopyUnique propertiesMass spectrometryMultimodal imagingNanoparticlesContrast agentsSpectrometry imagingSpectrometry analysisFluorocarbonSynthetic bloodFluorocarbon liquidAuNPsLiquidNanostructuresBiocompatibility