Featured Publications
Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation data
2023
Predictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study.
Pokharel Y, Kokkinidis D, Wang J, Gosch K, Safley D, Spertus J, Mena-Hurtado C, Smolderen K. Predictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study. Journal Of Endovascular Therapy 2023, 15266028231179574. PMID: 37309164, DOI: 10.1177/15266028231179574.Peer-Reviewed Original ResearchPredictors of revascularizationEarly revascularizationPeripheral artery diseaseExtensive diseasePAD symptomsSymptom burdenArtery diseaseOdds ratioLower Extremity Peripheral Artery DiseaseAnkle-brachial index scoreGoal-directed medical therapyEarly revascularization proceduresKnee arterial segmentsLifestyle-limiting claudicationRutherford class 3Peripheral arterial diseaseMonths of presentationPatient-level predictorsLower extremity PADMain predictorsMedian odds ratioHierarchical logistic regressionSymptomatic PADDisease guidelinesMedical therapyThe use of evidence-based medical therapy in patients with critical limb-threatening ischaemia.
Bager L, Petersen J, Havers-Borgersen E, Resch T, Smolderen K, Mena-Hurtado C, Eiberg J, Køber L, Fosbøl E. The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia. European Journal Of Preventive Cardiology 2023, 30: 1092-1100. PMID: 36708037, DOI: 10.1093/eurjpc/zwad022.Peer-Reviewed Original ResearchConceptsEvidence-based medical therapyARB/ACEILimb-threatening ischaemiaMyocardial infarctionMedical therapyHistory of MIHigh-risk patientsFirst-time hospitalizationUnadjusted odds ratioYears of ageMore comorbiditiesPatients 40Hazard ratioDanish registriesOverall mortalityAdjusted analysisAdverse prognosisOdds ratioPractice patternsPatientsMortality rateACEIIschaemiaTherapyMortality
2022
Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative
Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsChronic limb-threatening ischemiaLower extremity revascularizationAdverse limb eventsVascular Quality InitiativePeripheral artery diseaseYears of ageCommon ageLimb eventsArtery diseaseOutcomes of patientsLimb-threatening ischemiaGroup of patientsInsulin-dependent diabetesProportional hazards regressionQuality InitiativeUndergoing revascularizationMedical optimizationCurrent smokersD diseaseExtremity revascularizationPatient agePatients 60Medical therapyHazards regressionRATES OF GUIDELINE DIRECTED MEDICAL THERAPY IN PATIENTS WITH CRITICAL LIMB ISCHEMIA UNDERGOING MAJOR AMPUTATION: INSIGHTS FROM THE NATIONAL CERNER HEALTH FACTS ELECTRONIC HEALTH RECORD DATABASE
Provance J, Spertus J, Hoffman M, Jones P, Bunte M, Vogel T, Mena-Hurtado C, Smolderen K. RATES OF GUIDELINE DIRECTED MEDICAL THERAPY IN PATIENTS WITH CRITICAL LIMB ISCHEMIA UNDERGOING MAJOR AMPUTATION: INSIGHTS FROM THE NATIONAL CERNER HEALTH FACTS ELECTRONIC HEALTH RECORD DATABASE. Journal Of The American College Of Cardiology 2022, 79: 1771. DOI: 10.1016/s0735-1097(22)02762-0.Peer-Reviewed Original Research
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsGuideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention
Jelani QU, Llanos-Chea F, Bogra P, Trejo-Paredes C, Huang J, Provance JB, Turner J, Anantha-Narayanan M, Sheikh AB, Smolderen KG, Mena-Hurtado C. Guideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention. American Journal Of Nephrology 2021, 52: 845-853. PMID: 34706363, DOI: 10.1159/000519484.Peer-Reviewed Original ResearchConceptsComorbid chronic kidney diseaseGuideline-directed medical therapyPeripheral vascular interventionsCritical limb ischemiaMedian odds ratioMedical therapyPrescription ratesVascular interventionsHigh riskUse of GDMTAdjusted median odds ratioVascular Quality Initiative databaseAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersChronic kidney diseaseLower prescription ratesPoor clinical outcomeCKD groupCKD statusAntiplatelet therapyReceptor blockersLimb ischemiaLimb outcomesClinical outcomesMedical managementReal-world antithrombotic treatment variability in patients undergoing peripheral vascular intervention: Insights from the VQI registry
Lee M, Ahmed ZV, Huang J, Jelani QU, Aboian E, Peri-Okonny PA, Smolderen KG, Mena-Hurtado C. Real-world antithrombotic treatment variability in patients undergoing peripheral vascular intervention: Insights from the VQI registry. American Heart Journal 2021, 244: 31-35. PMID: 34688650, DOI: 10.1016/j.ahj.2021.10.186.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsDual antiplatelet therapySingle antiplatelet therapyAntiplatelet therapyVascular interventionsOptimal medical therapyNew trial dataAntithrombotic prescriptionMedical therapyPrescription ratesProvider factorsVQI registryTrial dataTherapyHealth systemPatientsTreatment variabilityPractice levelInterventionHigh levelsRegistryPhysiciansLack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia
Llanos-Chea F, Jelani QU, Trejo-Paredes C, Curtis JP, Parzynski CS, Huang J, Faridi KF, Turner J, Smolderen KG, Mena-Hurtado C. Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia. Journal Of The American College Of Cardiology 2021, 77: 1374-1375. PMID: 33706882, DOI: 10.1016/j.jacc.2020.12.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesEndovascular ProceduresFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemiaMaleMiddle AgedPeripheral Arterial DiseasePlatelet Aggregation Inhibitors
2016
Carotid artery stenting versus carotid endarterectomy
Nanna MG, Gomes P, Njoh RF, Ward C, Attaran RR, Mena C. Carotid artery stenting versus carotid endarterectomy. Postgraduate Medical Journal 2016, 92: 532-539. PMID: 27317752, DOI: 10.1136/postgradmedj-2015-133689.Peer-Reviewed Original ResearchConceptsCarotid endarterectomyCarotid artery stentingCarotid artery stenosisArtery stentingMedical therapyArtery stenosisCarotid stenosisTreatment optionsSurgical techniqueTreatment strategiesCarotid arteryMajor causeEndarterectomyStenosisStrokeMorbidityStentingArterySignificant contributorOptionsTherapyMortalityTrials
2014
Management of Symptomatic Carotid Disease in 2014
Litsky J, Stilp E, Njoh R, Mena-Hurtado C. Management of Symptomatic Carotid Disease in 2014. Current Cardiology Reports 2014, 16: 462. PMID: 24464307, DOI: 10.1007/s11886-013-0462-3.Peer-Reviewed Original ResearchConceptsSymptomatic carotid stenosisCarotid artery stentingCarotid endarterectomyCarotid stenosisMedical therapyHigh-grade symptomatic carotid stenosisExtracranial carotid artery stenosisPreventive medical therapyClass I recommendationSymptomatic carotid diseaseCarotid artery stenosisCause of deathRetinal symptomsStroke preventionArtery stentingI recommendationLandmark trialsPerioperative eventsArtery stenosisCarotid diseaseSymptomatic lesionsNoninvasive evaluationStenosisTherapyModern management
2013
An evidence‐based review of the impact of periprocedural myocardial infarction in carotid revascularization
Stilp E, Baird C, Gray WA, Schneider PA, Simonton CA, Verta P, Mena‐Hurtado C. An evidence‐based review of the impact of periprocedural myocardial infarction in carotid revascularization. Catheterization And Cardiovascular Interventions 2013, 82: 709-714. PMID: 23765902, DOI: 10.1002/ccd.25056.Peer-Reviewed Original ResearchConceptsPeriprocedural myocardial infarctionCarotid endarterectomyRevascularization strategyCarotid revascularizationMyocardial infarctionCarotid arteryIncidence of PMIAsymptomatic atherosclerotic stenosisCarotid revascularization strategiesPatient symptom statusLong-term morbidityCarotid artery stenosisExtracranial carotid arteriesEvidence-based reviewAsymptomatic patientsRevascularization TrialLandmark trialsMedical therapyArtery stenosisRandomized comparisonAtherosclerotic stenosisSymptom statusInvasive optionBiomarker assessmentRevascularization