Featured Publications
Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice usePROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE
Nikooie R, Smolderen K, Al-Damluji M, Meng C, Dai F, Nanna M, Sumpio B, Henke P, Mena-Hurtado C. PROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE. Journal Of The American College Of Cardiology 2022, 79: 1779. DOI: 10.1016/s0735-1097(22)02770-x.Peer-Reviewed Original ResearchThe Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk
Smolderen K, Heath K, Scherr T, Bauzon S, Howell A, Mena-Hurtado C. The Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk. European Journal Of Vascular And Endovascular Surgery 2022, 63: e98. DOI: 10.1016/j.ejvs.2022.06.013.Peer-Reviewed Original ResearchUse of drug-coated balloons and stents in patients with femoropopliteal artery disease and severe chronic kidney disease
Castro-Dominguez Y, Smolderen K, Romain G, Turner J, Mena-Hurtado C. Use of drug-coated balloons and stents in patients with femoropopliteal artery disease and severe chronic kidney disease. Vascular Medicine 2023, 28: 150-152. PMID: 36710497, DOI: 10.1177/1358863x221148521.Peer-Reviewed Original Research
2024
Antithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement
Bonaca M, Barnes G, Bauersachs R, Bessada Y, Conte M, Dua A, Hess C, Serhal M, Mena-Hurtado C, Weitz J, Beckman J. Antithrombotic Strategies for Patients With Peripheral Artery Disease JACC Scientific Statement. Journal Of The American College Of Cardiology 2024, 84: 936-952. PMID: 39197984, DOI: 10.1016/j.jacc.2024.06.027.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseAntithrombotic strategiesArtery diseaseResponse to antithrombotic therapyLimb eventsRisk of bleedingCoronary artery diseaseAdverse limb eventsAntithrombotic therapyMultidisciplinary working groupClinical scenariosPatientsAssessment of benefit-riskBenefit-riskAnticoagulationDiseaseScientific statementPatient-centeredBleedingMulti-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice
Callegari S, Feher A, Smolderen K, Mena-Hurtado C, Sinusas A. Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice. American Heart Journal Plus Cardiology Research And Practice 2024, 42: 100400. PMID: 38779485, PMCID: PMC11108852, DOI: 10.1016/j.ahjo.2024.100400.Peer-Reviewed Original ResearchPeripheral arterial diseaseMicrovascular diseasePeripheral microcirculationArtery diseaseEvaluation of response to therapyResponse to therapyManagement of peripheral arterial diseaseImprove risk stratificationOutcomes of peripheral artery diseaseAssessment of perfusionPathophysiology of peripheral arterial diseaseRisk of mortalityMolecular imaging studiesMulti-modal imagesPredictors of amputationRisk stratificationPre-clinicalImaging studiesClinical perfusionProcedural treatmentsClinical practicePersonalized managementMicrocirculationDiseasePerfusion
2023
A state-of-the-art review of quality-of-life assessment in venous disease
Cleman J, Xia K, Haider M, Nikooie R, Scierka L, Romain G, Attaran R, Grimshaw A, Mena-Hurtado C, Smolderen K. A state-of-the-art review of quality-of-life assessment in venous disease. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101725. PMID: 38128828, DOI: 10.1016/j.jvsv.2023.101725.Peer-Reviewed Original ResearchDisease-specific patient-reported outcome measurePatient-reported outcome measuresChronic venous diseaseCharing Cross Venous Ulcer QuestionnaireChronic Venous Insufficiency QuestionnaireVenous diseaseHealth statusVenous ulcersEvidence baseRelevant English-language studiesPatients' health statusContent validityEnglish-language studiesFull-text articlesManifestations of diseaseC6 diseaseOvid EmbaseInclusion criteriaOutcome measuresCommon conditionClinical settingDiseaseLiterature searchPatientsUlcersRepresentativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines
Castro-Dominguez Y, Mena-Hurtado C, Algara M, Obas V, Ahmed Z, Romain G, Solaru K, Smolderen K. Representativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines. The American Journal Of Cardiology 2023, 201: 166-169. PMID: 37385170, DOI: 10.1016/j.amjcard.2023.05.053.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD guidelinesArtery diseaseRecent American Heart Association/American CollegeAmerican Heart Association/American CollegeLower extremity peripheral artery diseaseOlder adult patientsRace/ethnicity distributionAdult patientsPooled proportionMean ageClinical trialsCurrent guidelinesEpidemiologic studiesAmerican CollegeTrial participantsRCTsEthnicity distributionOlder adultsTrialsWomenPatientsDiseaseGuidelinesEthnic groupsHealth Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Allison M, Armstrong D, Goodney P, Hamburg N, Kirksey L, Lancaster K, Mena-Hurtado C, Misra S, Treat-Jacobson D, Solaru K, Health O. Health Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 286-296. PMID: 37317860, DOI: 10.1161/cir.0000000000001153.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseClinical effectsAmerican Heart AssociationMajor limb amputationCerebrovascular eventsHeart AssociationHigh prevalenceLimb amputationHealth disparitiesInequitable deliveryInequitable burdenScientific statementHigh rateCertain demographic groupsDiseasePotential novel solutionIndividual disabilityOverview statementDemographic groupsAmputationDisparitiesPrevalenceCareStructural inequities
2022
Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease
Malik AO, Jones PG, Mena-Hurtado C, Burg MM, Shishehbor MH, Hejjaji V, Tran A, Spertus JA, Smolderen KG. Derivation and validation of a predictive model for chronic stress in patients with cardiovascular disease. PLOS ONE 2022, 17: e0275729. PMID: 36256655, PMCID: PMC9578618, DOI: 10.1371/journal.pone.0275729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseCardiovascular diseaseChronic stressWorse outcomesSymptomatic peripheral artery diseaseMyocardial Infarction RegistryLogistic regression modelsPAD patientsProspective registryCurrent smokingArtery diseaseClinical factorsDerivation cohortValidation cohortC-statisticFemale sexPerceived Stress ScalePatientsEconomic burdenMedical careInstrument scoresSocioeconomic statusPotential targetDiseasePSS-4 scoresThe Vascular Quality Initiative Assessment of the Bard Lifestent for the Treatment of Popliteal Artery Occlusive Disease
Bertges D, Eldrup-Jorgensen J, Eskandari M, Mena C, Mewissen M, Smith T, Woo E, Cronenwett J. The Vascular Quality Initiative Assessment of the Bard Lifestent for the Treatment of Popliteal Artery Occlusive Disease. Journal Of Vascular Surgery 2022, 76: e103-e104. DOI: 10.1016/j.jvs.2022.07.083.Peer-Reviewed Original ResearchEscalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.Peer-Reviewed Original ResearchCall for Formalized Pathways in Vascular Medicine Training JACC Review Topic of the Week
Eberhardt RT, Bonaca MP, Abu Daya H, Garcia LA, Gupta K, Mena-Hurtado C, Rogers RK, Sethi SS, Young MN, Piazza G. Call for Formalized Pathways in Vascular Medicine Training JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2022, 79: 2129-2139. PMID: 35618351, DOI: 10.1016/j.jacc.2022.03.365.Peer-Reviewed Original ResearchPATIENT PROFILES AND TRENDS IN PERIPHERAL ARTERY DISEASE AND MICROVASCULAR DISEASE: A RETROSPECTIVE ANALYSIS
Algara M, Luna P, Harris K, Tariq W, Smolderen K, Mena-Hurtado C. PATIENT PROFILES AND TRENDS IN PERIPHERAL ARTERY DISEASE AND MICROVASCULAR DISEASE: A RETROSPECTIVE ANALYSIS. Journal Of The American College Of Cardiology 2022, 79: 1802. DOI: 10.1016/s0735-1097(22)02793-0.Peer-Reviewed Original ResearchAssociation of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease
Tran AT, Spertus JA, Mena‐Hurtado C, Jones PG, Aronow HD, Safley DM, Malik AO, Peri‐Okonny P, Shishehbor MH, Labrosciano C, Smolderen KG. Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease. Journal Of The American Heart Association 2022, 11: e022232. PMID: 35132874, PMCID: PMC9245831, DOI: 10.1161/jaha.121.022232.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD-specific health statusHealth statusPAD symptomsArtery diseaseHierarchical Cox regression modelsDisease-specific health statusLong-term mortality riskTime of diagnosisCox regression modelLong-term survivalPORTRAIT registryCardiovascular morbidityCause mortalityResults PatientsKaplan-MeierMortality riskUnadjusted modelsSummary scoresUS sitesPatientsMortalityBaselineSymptomsDiseaseLower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative
Kim T, Loh S, Dewan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Chaar C. Lower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 79: 400-401. DOI: 10.1016/j.avsg.2021.12.049.Peer-Reviewed Original ResearchMajor adverse limb eventsLower extremity revascularizationPeripheral artery diseaseCommon ageExtremity revascularizationArtery diseaseAdverse limb eventsDe novo diseaseOutcomes of patientsVascular Quality InitiativeInsulin-dependent diabetesSevere disease burdenNovo diseaseTASC classificationConclusions PatientsPatient agePatients 60Poor outcomeDisease burdenSevere diseaseLimb eventsPatientsLogistic regressionOne-yearDisease
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsPeripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry
Smolderen KG, Lee M, Arora T, Simonov M, Mena-Hurtado C. Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry. Current Problems In Cardiology 2021, 47: 101007. PMID: 34627824, PMCID: PMC8496926, DOI: 10.1016/j.cpcardiol.2021.101007.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSARS-CoV-2Myocardial infarctionMajor adverse cardiovascular eventsAdverse cardiovascular eventsPeripheral artery diseaseOdds of mortalityCOVID-19 infectionCOVID-19 outcomesLogistic regression modelsCardiovascular eventsArtery diseaseArterial diseaseMean ageRisk factorsWorse outcomesPatientsMinority raceMortalityRegistryStrokeDiseaseMACERegression modelsOutcomesTrends in drug-coated device use for peripheral artery disease: Insights from the Vascular Quality Initiative (VQI)
Pichert MD, Smolderen KG, Castro-Dominguez Y, Jelani QU, Nagpal S, Provance JB, Huang J, Malik AO, Secemsky EA, Derbas LA, Mena-Hurtado CI. Trends in drug-coated device use for peripheral artery disease: Insights from the Vascular Quality Initiative (VQI). Vascular Medicine 2021, 27: 73-74. PMID: 34610776, DOI: 10.1177/1358863x211043567.Peer-Reviewed Original ResearchTreatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid
Smolderen KG, Pacheco C, Provance J, Stone N, Fuss C, Decker C, Bunte M, Jelani QU, Safley DM, Secemsky E, Sepucha KR, Spatz ES, Mena-Hurtado C, Spertus JA. Treatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid. Vascular Medicine 2021, 26: 273-280. PMID: 33627058, PMCID: PMC8169642, DOI: 10.1177/1358863x20988780.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseTreatment optionsSymptoms of claudicationInvasive treatment optionNon-invasive treatmentQuality of lifeClaudication symptomsClaudication treatmentPatient knowledgeSpecialty careTreatment decisionsDecision aidPatientsCliniciansDecisional needsInternational Patient Decision Aid Standards criteriaStandard criteriaPrototype decision aidImplementation logisticsSymptomsDecisional qualityDiseaseTreatmentClaudication