2001
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
Elgoyhen A, Vetter D, Katz E, Rothlin C, Heinemann S, Boulter J. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 3501-3506. PMID: 11248107, PMCID: PMC30682, DOI: 10.1073/pnas.051622798.Peer-Reviewed Original ResearchConceptsHair cellsMechanosensory hair cellsCholinergic receptor functionAgonist-mediated desensitizationHair cell functionAlpha9 nAChREfferent modulationHeteromeric nAChRsAlpha9alpha10 nAChRsPharmacological profileBiphasic responseMammalian vestibularReceptor functionAlpha10 subunitsNAChRsCell functionAlpha9Xenopus laevis oocytesCurrent-voltage relationshipVertebrate hair cellsSubunit geneLaevis oocytesAlpha10CellsAlpha9alpha10
2000
High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor
Katz E, Verbitsky M, Rothlin C, Vetter D, Heinemann S, Elgoyhen A. High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor. Hearing Research 2000, 141: 117-128. PMID: 10713500, DOI: 10.1016/s0378-5955(99)00214-2.Peer-Reviewed Original ResearchConceptsOuter hair cellsAlpha9 receptorNicotinic acetylcholine receptorsAcetylcholine receptorsAlpha9 nicotinic acetylcholine receptorΑ9 nicotinic acetylcholine receptorHair cellsOlivocochlear efferent fibersHigh calcium permeabilityAuditory nerve fiber activityNerve fiber activityEfferent fibersCholinergic receptorsOlivocochlear fibersVoltage-dependent mannerSynaptic transmissionCalcium permeabilityInhibitory synapseFiber activityReceptorsXenopus laevis oocytesMonovalent currentsLaevis oocytesSynapseCalcium block