The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors
Rothlin C, Katz E, Verbitsky M, Elgoyhen A. The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors. Molecular Pharmacology 1999, 55: 248-254. PMID: 9927615, DOI: 10.1124/mol.55.2.248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBariumBicucullineCalciumChelating AgentsDNA, ComplementaryEgtazic AcidFemaleGABA AntagonistsGlycineGlycine AgentsIndolesMembrane PotentialsOocytesReceptors, GABA-AReceptors, GlycineReceptors, NicotinicReceptors, SerotoninReceptors, Serotonin, 5-HT3Recombinant Fusion ProteinsSerotoninSerotonin AntagonistsStrychnineTropisetronXenopus laevisConceptsPharmacological propertiesGamma-aminobutyric acid receptor antagonist bicucullineAlpha9 nicotinic acetylcholine receptorACh-evoked currentsAgonist maximal responseType 3 serotonin receptorReceptor antagonist bicucullineGlycinergic antagonist strychnineGamma-aminobutyric acidNicotinic acetylcholine receptorsSimilar pharmacological propertiesCochlear outer hair cellsOuter hair cellsConcentration-dependent mannerCys-loop familyAlpha9 nAChRAntagonist bicucullineAntagonist strychnineCholinergic receptorsΓ-aminobutyric acidCys-loop receptorsSerotonin receptorsMaximal responseAcetylcholine receptorsHair cells