2024
Adolescent Residential Addiction Treatment In The US: Uneven Access, Waitlists, And High Costs
King C, Beetham T, Smith N, Englander H, Button D, Brown P, Hadland S, Bagley S, Wright O, Korthuis P, Cook R. Adolescent Residential Addiction Treatment In The US: Uneven Access, Waitlists, And High Costs. Health Affairs 2024, 43: 64-71. PMID: 38190597, PMCID: PMC11082498, DOI: 10.1377/hlthaff.2023.00777.Peer-Reviewed Original ResearchConceptsUse disordersRecent nonfatal overdoseOpioid use disorderResidential addiction treatment facilityResidential addiction treatment centerSelf-pay patientsSubstance use disordersDrug overdose deathsAddiction treatment facilitiesAddiction treatment centersResidential addiction treatmentNonfatal overdoseSixteen-year-old childrenTreatment optionsHalf of facilitiesMean costOverdose deathsTreatment centersResidential treatment facilitySubstance abuseAddiction treatment
2023
Treatments Used Among Adolescent Residential Addiction Treatment Facilities in the US, 2022
King C, Beetham T, Smith N, Englander H, Hadland S, Bagley S, Korthuis P. Treatments Used Among Adolescent Residential Addiction Treatment Facilities in the US, 2022. JAMA 2023, 329: 1983-1985. PMID: 37314282, PMCID: PMC10265296, DOI: 10.1001/jama.2023.6266.Peer-Reviewed Original Research
2022
A Comparison of Patient- and Clinician-Reported Acute Toxic Effects During Radiation Therapy for Primary Breast Cancer
Lapen K, King C, Braunstein L, Khan A, Kamrava M, Gillespie E, Cook K. A Comparison of Patient- and Clinician-Reported Acute Toxic Effects During Radiation Therapy for Primary Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: 301-309. PMID: 35675851, PMCID: PMC10281649, DOI: 10.1016/j.ijrobp.2022.05.041.Peer-Reviewed Original ResearchConceptsPrimary breast cancerRadiation therapyAcute toxic effectsClinician assessmentBreast cancerPatients warrants further investigationTreatment-related toxic effectsToxic effectsPatient-clinician pairsSymptom burden scoresCommon Terminology CriteriaComparison of patientsStart of treatmentBreast radiation therapyWarrants further investigationTerminology CriteriaAdverse eventsSymptom burdenOutcomes versionPatients' qualityBurden scoreProspective studyUnique patientsLow-severity symptomsPatient responseExpanding Inpatient Addiction Consult Services Through Accountable Care Organizations for Medicaid Enrollees: A Modeling Study
King C, Cook R, Korthuis P, McCarty D, Morris C, Englander H. Expanding Inpatient Addiction Consult Services Through Accountable Care Organizations for Medicaid Enrollees: A Modeling Study. Journal Of Addiction Medicine 2022, 16: 570-576. PMID: 35135988, PMCID: PMC9357852, DOI: 10.1097/adm.0000000000000972.Peer-Reviewed Original ResearchConceptsOpioid use disorderCoordinated Care OrganizationsAccountable care organizationsTreatment engagementHospitalized patientsUse disordersCare organizationsAddiction consult serviceMedicaid accountable care organizationsOut-patient careSubstance use disordersStudy objectiveACS careMore patientsOUD treatmentOUD careOutpatient treatmentConsult serviceMedicaid enrolleesMedicaid patientsTreatment accessMedicaid dataPatientsService careAddiction careDifferences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;
Priest K, King C, Englander H, Lovejoy T, McCarty D. Differences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;. Substance Abuse 2022, 43: 1251-1259. PMID: 35670778, PMCID: PMC10292919, DOI: 10.1080/08897077.2022.2074601.Peer-Reviewed Original ResearchConceptsOpioid use disorderVeterans Health AdministrationWhite patientsUse disordersMOUD deliveryBlack patientsDelivery of buprenorphineType of MOUDRetrospective cohort analysisAcute care hospitalsCOVID-19 pandemic continuesDelivery of medicationsOutpatient clinical environmentLogistic regression modelsMOUD accessAddiction treatment systemCare hospitalStudy cohortSurgical hospitalizationMean ageCohort analysisHospitalizationMOUDPatientsBuprenorphine
2021
Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder
Merlin JS, Khodyakov D, Arnold R, Bulls HW, Dao E, Kapo J, King C, Meier D, Paice J, Ritchie C, Liebschutz JM. Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder. JAMA Network Open 2021, 4: e2139968. PMID: 34962565, DOI: 10.1001/jamanetworkopen.2021.39968.Peer-Reviewed Original ResearchConceptsOpioid use disorderFull agonist opioidsAdvanced cancerUncertain appropriatenessCancer painPalliative careUse disordersCancer pain managementAppropriateness of managementExpert panel consensusConsensus-based guidanceImportant comorbidityOpioid medicationsPain managementMethadone clinicsPainPatientsPanel consensusPrognosisCancerMethadoneDelphi processExpert panelMonthsOpioidsSimulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality
King C, Cook R, Wheelock H, Korthuis P, Leahy J, Goff A, Morris C, Englander H. Simulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality. International Journal Of Drug Policy 2021, 100: 103525. PMID: 34837879, PMCID: PMC8810590, DOI: 10.1016/j.drugpo.2021.103525.Peer-Reviewed Original ResearchConceptsAddiction consult serviceOpioid use disorderDrug-related deathsConsult serviceHospital dischargeCare systemDrug-related causesOpioid-related deathsDrug supplyRisk of overdoseDrug-related mortalityOpioid overdose deathsHarm reduction interventionsAdult patientsOUD patientsHospital admissionOpioid overdosesEffective treatmentOverdose deathsSimulated cohortPatientsUse disordersReduction interventionsHospitalizationDeathCorrelates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam
Button D, Cook R, King C, Khuyen T, Kunkel L, Bart G, Thuy D, Nguyen D, Blazes C, Giang L, Korthuis P. Correlates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam. International Journal Of Drug Policy 2021, 100: 103503. PMID: 34768124, PMCID: PMC8810676, DOI: 10.1016/j.drugpo.2021.103503.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyTreatment exposureMultivariate modelOpioid use disorderDisorder exposureHIV clinicMaintenance therapyPrimary outcomeUse disordersNegative binomial regressionMOUDHIVMedicationsBinomial regressionPatientsExposureDaysMonthsOUDParticipantsBuprenorphineMethadoneClinicReferralTherapyAssociations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease
Cook R, Torralva R, King C, Lum P, Tookes H, Foot C, Vergara-Rodriguez P, Rodriguez A, Fanucchi L, Lucas G, Waddell E, Korthuis P. Associations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease. Drug And Alcohol Dependence 2021, 228: 109077. PMID: 34600253, PMCID: PMC8595584, DOI: 10.1016/j.drugalcdep.2021.109077.Peer-Reviewed Original ResearchConceptsUncontrolled HIV diseaseFentanyl useOpioid use disorderXR-NTXHIV diseaseUse disordersTreatment of OUDUncontrolled HIV infectionExtended-release naltrexoneHIV viral suppressionUrine drug screeningExposure of interestMultisite clinical trialPercent of participantsMethadone administrationMOUD initiationMOUD retentionViral suppressionBuprenorphine prescriptionsHIV infectionClinical trialsWeek 20First injectionAdministrationMOUDDesigning and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality
King C, Englander H, Korthuis P, Barocas J, McConnell K, Morris C, Cook R. Designing and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality. PLOS ONE 2021, 16: e0256793. PMID: 34506517, PMCID: PMC8432751, DOI: 10.1371/journal.pone.0256793.Peer-Reviewed Original ResearchConceptsAddiction consult serviceOpioid use disorderDrug-related deathsHospitalized patientsOUD careRelated mortalityPercent of patientsNon-drug related deathTrajectory of careSubstance use treatmentLogistic regression modelsACS careOUD treatmentPatient survivalRelated deathsSUD careConsult serviceMedicaid dataPatientsUse disordersMortalityUse treatmentCareBayesian logistic regression modelDeathCauses of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder
King C, Cook R, Korthuis P, Morris C, Englander H. Causes of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder. Journal Of Addiction Medicine 2021, 16: 466-469. PMID: 34510087, PMCID: PMC8907339, DOI: 10.1097/adm.0000000000000915.Peer-Reviewed Original ResearchConceptsOpioid use disorderCause of deathDrug-related deathsUse disordersHospitalized patientsDiagnosis of OUDGeneral hospital admissionsPost-discharge mortalityDrug-related causesAverage hospital lengthRisk of deathSubstance use disordersHospital lengthHospital dischargeHospital admissionMedicaid insuranceOUD diagnosisDrug overdoseMedicaid patientsFrequent causeHigh riskGeneral populationPatientsAverage ageCare systemA hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment
Seaman A, King C, Kaser T, Geduldig A, Ronan W, Cook R, Chan B, Levander X, Priest K, Korthuis P. A hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment. International Journal Of Drug Policy 2021, 96: 103359. PMID: 34325969, PMCID: PMC8720290, DOI: 10.1016/j.drugpo.2021.103359.Peer-Reviewed Original ResearchConceptsDirect acting antiviralsLogistic regression modelsCascade progressionHepatitis C elimination targetsCox proportional hazards modelMultiple logistic regression modelHCV care cascadeHCV treatment cascadeSingle blood drawPresence of opioidsLikelihood of screeningProportional hazards modelTreatment of peopleHCV screeningCare cascadeHCV treatmentActing antiviralsBundle interventionsMultinomial logistic regression modelsPatient characteristicsHCV PCRTreatment cascadeTreatment initiationHomeless clinicRegression modelsConsensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process
King C, Arnold R, Dao E, Kapo J, Liebschutz J, Meier D, Paice J, Ritchie C, Czajkowski K, Khodyakov D, Merlin J. Consensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process. BMJ Open 2021, 11: e045402. PMID: 34011593, PMCID: PMC8137210, DOI: 10.1136/bmjopen-2020-045402.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid misuseSerious illnessInstitutional review boardUse disordersBenefits of opioidsOpioid-related harmsPalliative care cliniciansInstitutional Research BoardPittsburgh Institutional Review BoardOpioid therapyPain managementCare cliniciansPalliative careClinical guidanceEthical approvalIllnessReview boardCliniciansDelphi processPatient casesImplementation toolkitRound 1OpioidsFinal consensusIncarceration and compulsory rehabilitation impede use of medication for opioid use disorder and HIV care engagement in Vietnam
King C, Cook R, Giang L, Bart G, Hoffman K, Waddell E, Korthuis P. Incarceration and compulsory rehabilitation impede use of medication for opioid use disorder and HIV care engagement in Vietnam. Journal Of Substance Use And Addiction Treatment 2021, 134: 108451. PMID: 33962813, PMCID: PMC8558110, DOI: 10.1016/j.jsat.2021.108451.Peer-Reviewed Original ResearchConceptsOpioid use disorderMonth 9Use disordersClinic engagementAntiretroviral therapy prescriptionNon-prescribed opioid useCompulsory rehabilitationHIV treatment outcomesHIV viral suppressionHIV care engagementUse of medicationsNon-prescribed opioidsCompulsory rehabilitation centersEvidence-based strategiesHIV clinicViral suppressionOpioid useHIV treatmentCare engagementMonths 0Therapy prescriptionClinical trialsTreatment outcomesTreatment accessMOUDUnderstanding the impact of the SARS-COV-2 pandemic on hospitalized patients with substance use disorder
King C, Vega T, Button D, Nicolaidis C, Gregg J, Englander H. Understanding the impact of the SARS-COV-2 pandemic on hospitalized patients with substance use disorder. PLOS ONE 2021, 16: e0247951. PMID: 33635926, PMCID: PMC7909702, DOI: 10.1371/journal.pone.0247951.Peer-Reviewed Original ResearchConceptsSubstance use disordersSARS-CoV-2 pandemicHospitalized patientsUse disordersHospital policy changesAcademic medical centerExperiences of healthcareAcute illnessOutpatient careMedical CenterPatientsHospitalCommunity resourcesDisordersPandemicQualitative studyThematic analysisSemi-structured interviewsSurvival adaptationHospitalizationIllnessMain themesCareTrust in Hospital Physicians Among Patients With Substance Use Disorder Referred to an Addiction Consult Service: A Mixed-methods Study
King C, Collins D, Patten A, Nicolaidis C, Englander H. Trust in Hospital Physicians Among Patients With Substance Use Disorder Referred to an Addiction Consult Service: A Mixed-methods Study. Journal Of Addiction Medicine 2021, 16: 41-48. PMID: 33577229, PMCID: PMC8349928, DOI: 10.1097/adm.0000000000000819.Peer-Reviewed Original ResearchConceptsAddiction consult serviceSubstance use disordersConsult serviceUse disordersAddiction medicine serviceGroup of patientsPatient-physician relationshipHospital dischargeHospitalized patientsPrior hospitalizationMedicine servicePatientsHospital physiciansHospitalized peopleHealthcare providersHospitalizationHospital trustsProvider trustMixed-methods studyMost participantsQualitative themesPhysiciansBaselineCareDisordersHIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial
Korthuis P, King C, Cook R, Khuyen T, Kunkel L, Bart G, Nguyen T, Thuy D, Bielavitz S, Nguyen D, Tam N, Giang L. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. The Lancet HIV 2021, 8: e67-e76. PMID: 33539760, PMCID: PMC8082651, DOI: 10.1016/s2352-3018(20)30302-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBuprenorphineCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedNaloxoneNarcotic AntagonistsNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersPatient ComplianceRandom AllocationRNA, ViralTreatment OutcomeVietnamViral LoadConceptsMethadone maintenance therapyOpioid use disorderHIV viral suppressionMaintenance therapySerious adverse eventsViral suppressionAdverse eventsNon-inferiority trialUse disordersHIV clinicNaloxone treatmentComputer-generated random number sequenceOpioid use disorder medicationsTreatment-emergent adverse eventsHIV clinic visitsQuarterly study visitsBuprenorphine adherenceCD4 countHIV careClinic visitsBuprenorphine treatmentHIV outcomesMiddle-income countriesPrimary outcomeMean age
2020
Converging Crises: Caring for Hospitalized Adults With Substance Use Disorder in the Time of COVID‐19
Englander H, Salisbury‐Afshar E, Gregg J, Martin M, Snyder H, Weinstein Z, King C. Converging Crises: Caring for Hospitalized Adults With Substance Use Disorder in the Time of COVID‐19. Journal Of Hospital Medicine 2020, 15: 628-630. PMID: 32966196, PMCID: PMC7531943, DOI: 10.12788/jhm.3485.Peer-Reviewed Original ResearchEvaluating new paralysis, mortality, and readmission among subgroups of patients with spinal epidural abscess: A latent class analysis
Brown P, Phillipi G, King C, Tanski M, Sullivan P. Evaluating new paralysis, mortality, and readmission among subgroups of patients with spinal epidural abscess: A latent class analysis. PLOS ONE 2020, 15: e0238853. PMID: 32915861, PMCID: PMC7485888, DOI: 10.1371/journal.pone.0238853.Peer-Reviewed Original ResearchConceptsSpinal epidural abscessSubgroup of patientsClinical outcomesPatient populationGroup 2Group 1Longer hospital courseSubstance use disorder diagnosisLatent class analysisSubstance use disordersChi-square testCharacteristics of subgroupsHospital mortalityEpidural abscessHospital courseMedical comorbiditiesSignificant morbidityVascular accessRisk factorsClinical subgroupsHealth centersSupport patientsHigh riskPatientsSubsequent mortalityCommunity-derived recommendations for healthcare systems and medical students to support people who are houseless in Portland, Oregon: a mixed-methods study
King C, Fisher C, Johnson J, Chun A, Bangsberg D, Carder P. Community-derived recommendations for healthcare systems and medical students to support people who are houseless in Portland, Oregon: a mixed-methods study. BMC Public Health 2020, 20: 1337. PMID: 32878612, PMCID: PMC7466795, DOI: 10.1186/s12889-020-09444-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude to HealthBehavior, AddictiveDelivery of Health CareFemaleHealth Services Needs and DemandHousingHumansIll-Housed PersonsMaleMental DisordersMental HealthMiddle AgedOregonPatient AdvocacyPopulation HealthProfessional-Patient RelationsQualitative ResearchSocial ChangeSocial StigmaSocial SupportStudents, MedicalSubstance-Related DisordersSurveys and QuestionnairesConceptsCommunity-based organizationsQualitative interview guideSelf-identified needsMixed-methods surveyInstitutional levelSemi-structured qualitative interview guideHouselessMixed-methods studyQualitative dataDisproportionate disparitiesThematic analysisInstitutionsQualitative themesInterview guideHouselessnessTraining institutionsPeopleCare experiencesHealth of peopleHealthcare systemTime of interviewMental health conditionsSubstance use disordersCommunityStigma