Correlates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam
Button D, Cook R, King C, Khuyen T, Kunkel L, Bart G, Thuy D, Nguyen D, Blazes C, Giang L, Korthuis P. Correlates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam. International Journal Of Drug Policy 2021, 100: 103503. PMID: 34768124, PMCID: PMC8810676, DOI: 10.1016/j.drugpo.2021.103503.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyTreatment exposureMultivariate modelOpioid use disorderDisorder exposureHIV clinicMaintenance therapyPrimary outcomeUse disordersNegative binomial regressionMOUDHIVMedicationsBinomial regressionPatientsExposureDaysMonthsOUDParticipantsBuprenorphineMethadoneClinicReferralTherapyHIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial
Korthuis P, King C, Cook R, Khuyen T, Kunkel L, Bart G, Nguyen T, Thuy D, Bielavitz S, Nguyen D, Tam N, Giang L. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. The Lancet HIV 2021, 8: e67-e76. PMID: 33539760, PMCID: PMC8082651, DOI: 10.1016/s2352-3018(20)30302-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBuprenorphineCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedNaloxoneNarcotic AntagonistsNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersPatient ComplianceRandom AllocationRNA, ViralTreatment OutcomeVietnamViral LoadConceptsMethadone maintenance therapyOpioid use disorderHIV viral suppressionMaintenance therapySerious adverse eventsViral suppressionAdverse eventsNon-inferiority trialUse disordersHIV clinicNaloxone treatmentComputer-generated random number sequenceOpioid use disorder medicationsTreatment-emergent adverse eventsHIV clinic visitsQuarterly study visitsBuprenorphine adherenceCD4 countHIV careClinic visitsBuprenorphine treatmentHIV outcomesMiddle-income countriesPrimary outcomeMean age