Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis
Banini BA, Cazanave SC, Yates KP, Asgharpour A, Vincent R, Mirshahi F, Le P, Contos MJ, Tonascia J, Chalasani NP, Kowdley KV, McCullough AJ, Behling CA, Schwimmer JB, Lavine JE, Sanyal AJ. Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis. Journal Of Clinical Gastroenterology 2019, 53: 750-758. PMID: 30586008, PMCID: PMC6588507, DOI: 10.1097/mcg.0000000000001142.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesFemaleGenotypeHaptoglobinsHumansMaleNon-alcoholic Fatty Liver DiseaseRandomized Controlled Trials as TopicTreatment OutcomeVitamin EConceptsNonalcoholic fatty liver disease activity scoreNonalcoholic steatohepatitisLiver enzymesHistologic responseHp genotypeVitamin ENonalcoholic fatty liver diseaseResolution of steatohepatitisSignificant histologic improvementDisease Activity ScoreFatty liver diseaseHp 1 alleleRegression analysisEffect of VitEHaptoglobin 2 alleleDifferential treatment effectsGreater histologicCardiovascular outcomesHistologic improvementDiabetes mellitusLaboratory markersActivity scoreLiver diseaseHistologic featuresFibrosis stage