2016
Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2015
Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study
Kober H, Lacadie CM, Wexler BE, Malison RT, Sinha R, Potenza MN. Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study. Neuropsychopharmacology 2015, 41: 628-637. PMID: 26119472, PMCID: PMC5130138, DOI: 10.1038/npp.2015.193.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCD participantsCocaine dependenceCocaine cravingPG participantsPathological gamblingGender-specific therapiesBrain activityMagnetic resonance imagingNeural correlatesSelf-reported cravingInsula/Ventromedial prefrontal cortexNeurobiological similaritiesResonance imagingGambling urgesDrug cravingPrefrontal cortexDorsal mPFCControl participantsCravingFMRI studyMPFC regionFuture studiesParticipants
2014
Physiological evidence of a deficit to enhance the empathic response in schizophrenia
Corbera S, Ikezawa S, Bell MD, Wexler BE. Physiological evidence of a deficit to enhance the empathic response in schizophrenia. European Psychiatry 2014, 29: 463-472. PMID: 24630376, DOI: 10.1016/j.eurpsy.2014.01.005.Peer-Reviewed Original ResearchConceptsEvent-related potentialsEmpathic responsesERP responsesPersonal distressRegulatory deficitsLate cognitive componentsSocial cognition processesPictures of handsEffective social interactionsLate ERP responsesOwn emotional engagementCognitive empathyTask demandsPerspective takingCognition processEmpathic conditionEmotional engagementSocial situationsSocial interactionEmpathyPainful situationsSubjective ratingsOwn painPain paradigmDistressNeuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipantsIncreasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuliNeural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrusBenefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning
Bell MD, Choi KH, Dyer C, Wexler BE. Benefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning. Psychiatric Services 2014, 65: 469-475. PMID: 24382594, DOI: 10.1176/appi.ps.201200505.Peer-Reviewed Original Research
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsA pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia
Surti TS, Wexler BE. A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophrenia Research 2012, 142: 248-249. PMID: 23043873, DOI: 10.1016/j.schres.2012.09.013.Peer-Reviewed Original ResearchDoes baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2011
Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates?
Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates? Schizophrenia Bulletin 2011, 39: 186-196. PMID: 21976710, PMCID: PMC3523908, DOI: 10.1093/schbul/sbr125.Peer-Reviewed Original ResearchConceptsHigher social cognitionLower social cognitionSocial cognitive impairmentsHigh-negative symptom groupSocial cognitionNegative-symptom groupNegative symptomsCaruso Emotional Intelligence TestSocial cognitive measuresEmotional Intelligence TestSocial cognitive factorsCognitive impairmentSymptom groupsNegative symptom factorMayer-SaloveyCommon assessment instrumentsCognitive factorsCognitive measuresSubstance abuse historyIntelligence testsCore featuresAbuse historyIndependent dimensionsDistinct factorsSymptom factorsSuccessful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipants
2010
Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures
Bell MD, Fiszdon JM, Greig TC, Wexler BE. Social attribution test — multiple choice (SAT-MC) in schizophrenia: Comparison with community sample and relationship to neurocognitive, social cognitive and symptom measures. Schizophrenia Research 2010, 122: 164-171. PMID: 20400268, PMCID: PMC2908733, DOI: 10.1016/j.schres.2010.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceChoice BehaviorCognition DisordersDisability EvaluationFemaleHumansInterpersonal RelationsLogistic ModelsMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesReproducibility of ResultsResidence CharacteristicsROC CurveSchizophreniaSchizophrenic PsychologySocial PerceptionConceptsSocial Attribution Task-Multiple ChoiceSocial cognitive measuresCognitive measuresAffect recognitionCommunity sampleSocial cognitive impairmentsTheory of mindSignificant group differencesMATRICS batteryNeurocognitive measuresSCZ participantsVerbal processesAutism researchCognition indexLongitudinal designSymptom measuresGroup differencesCognitive impairmentCommunity-dwelling participantsGeometric figuresSchizoaffective disorderParticipantsSchizophreniaImpairmentMultiple-choice questionsMemory profiles in schizophrenia: Categorization validity and stability
Bell MD, Johannesen JK, Greig TC, Wexler BE. Memory profiles in schizophrenia: Categorization validity and stability. Schizophrenia Research 2010, 118: 26-33. PMID: 20085855, PMCID: PMC3699867, DOI: 10.1016/j.schres.2009.12.037.Peer-Reviewed Original ResearchConceptsSocial cognitive domainsMemory profileCognitive domainsHopkins Verbal LearningCluster analytic techniquesSocial cognitionVerbal learningVerbal memorySubcortical impairmentNeuropsychological assessmentCommunity mental health centerCortical impairmentMental health centersSchizoaffective disorderMotor speedCurrent studySchizophreniaIllness characteristicsMemoryUrban community mental health centerImpairmentSimple decision rulesCognitionCluster analysisCluster groups
2008
Predictors of change in life skills in schizophrenia after cognitive remediation
Kurtz MM, Seltzer JC, Fujimoto M, Shagan DS, Wexler BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research 2008, 107: 267-274. PMID: 19006657, PMCID: PMC3399665, DOI: 10.1016/j.schres.2008.10.014.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersComprehensionComputer-Assisted InstructionFemaleHumansInhibition, PsychologicalMemory, Short-TermMiddle AgedNeuropsychological TestsProblem SolvingPrognosisPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceRemedial TeachingSchizophreniaSchizophrenic PsychologySocializationSoftwareVerbal LearningYoung AdultConceptsCognitive remediationAuditory attentionPerformance-based measuresRemediation interventionsComputer-assisted cognitive remediationLife skillsCognitive remediation interventionsSustained auditory attentionEveryday life skillsTreatment-related improvementTreatment process variablesOutpatient rehabilitation treatmentPredictors of changeMeasures of symptomsVerbal abilityVerbal learningTreatment outcome measuresNeurocognitive variablesNeurocognitive functionMemoryNegative symptomsSchizoaffective disorderPredictor studiesCurrent studySchizophreniaNeuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia
Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, Colibazzi T, Amat J, Bansal R, Peterson BS. Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia. American Journal Of Psychiatry 2008, 166: 189-195. PMID: 18765481, PMCID: PMC4288572, DOI: 10.1176/appi.ajp.2008.08020258.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsComparison subjectsCognitive deficitsCalifornia Verbal Learning TestScores one standard deviationTests of attentionVerbal Learning TestContinuous Performance TestLarger third ventricle volumesMixed-model multivariate analysisSmaller gray matterWhite matterVentricle volumeSevere cognitive deficitsBrain structure abnormalitiesGray matterLearning TestLarger lateral ventricle volumesCognitive testsThird ventricle volumesLateral ventricle volumeWhite matter pathologySmaller white matterImpaired groupNeuropsychological testingSymptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation
Kurtz MM, Wexler BE, Fujimoto M, Shagan DS, Seltzer JC. Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research 2008, 102: 303-311. PMID: 18495433, PMCID: PMC2519168, DOI: 10.1016/j.schres.2008.03.023.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAmbulatory CareCognition DisordersCognitive Behavioral TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyTherapy, Computer-AssistedVerbal LearningConceptsEveryday life skillsPerformance-based measuresLife skillsVerbal learningVerbal abilityCognitive rehabilitation interventionLongitudinal studyPredictors of changeMeasures of symptomsCognitive interventionsVisual vigilanceSustained vigilanceProcessing speedNeurocognitive deficitsNeurocognitive functionNegative symptomsBody of literatureNeurocognitionSkillsRehabilitation interventionsSchizoaffective disorderOutpatient rehabilitationCurrent studySchizophreniaRehabilitation strategies
2007
Predictors of on-site vocational support for people with schizophrenia in supported employment
Zito W, Greig TC, Wexler BE, Bell MD. Predictors of on-site vocational support for people with schizophrenia in supported employment. Schizophrenia Research 2007, 94: 81-88. PMID: 17512172, PMCID: PMC1986779, DOI: 10.1016/j.schres.2007.03.026.Peer-Reviewed Original Research
2006
Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient?
Kurtz MM, Seltzer JC, Shagan DS, Thime WR, Wexler BE. Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research 2006, 89: 251-260. PMID: 17070671, PMCID: PMC2095777, DOI: 10.1016/j.schres.2006.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognition DisordersComputer User TrainingComputer-Assisted InstructionFemaleHumansMaleMemory, Short-TermMental RecallMiddle AgedNeuropsychological TestsPattern Recognition, VisualProblem SolvingReaction TimeRemedial TeachingSchizophreniaSchizophrenic LanguageSchizophrenic PsychologySpeech PerceptionConceptsComputer-assisted cognitive remediationTraining control conditionCognitive remediationNeurocognitive functionComprehensive neuropsychological test batteryCognitive remediation interventionsCognitive remediation trainingSpatial episodic memoryControl conditionNeuropsychological test batteryEpisodic memoryComplex behavioral treatmentsBody of researchCognitive stimulationRemediation interventionsCognitive challengesNeurocognitive testsProcessing speedBehavioral treatmentTest batteryMemoryExperimental interventionSchizophreniaNon-specific stimulationIntervention