2014
Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrus
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2008
Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia
Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, Colibazzi T, Amat J, Bansal R, Peterson BS. Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia. American Journal Of Psychiatry 2008, 166: 189-195. PMID: 18765481, PMCID: PMC4288572, DOI: 10.1176/appi.ajp.2008.08020258.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsComparison subjectsCognitive deficitsCalifornia Verbal Learning TestScores one standard deviationTests of attentionVerbal Learning TestContinuous Performance TestLarger third ventricle volumesMixed-model multivariate analysisSmaller gray matterWhite matterVentricle volumeSevere cognitive deficitsBrain structure abnormalitiesGray matterLearning TestLarger lateral ventricle volumesCognitive testsThird ventricle volumesLateral ventricle volumeWhite matter pathologySmaller white matterImpaired groupNeuropsychological testing
2005
Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients. Neuropsychopharmacology 2005, 31: 644-650. PMID: 16123763, DOI: 10.1038/sj.npp.1300851.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPosterior cingulate cortexCocaine-related cuesCocaine-dependent patientsBrain activationTreatment effectiveness scoreSensory association corticesBrain activity changesPCC activationCocaine cuesSuperior temporalBOLD activationCingulate cortexSubjective reportsTreatment developmentAssociation cortexCuesProcessing areasCocaine abusePhysiological activationCortexNonrelapsersBest predictorCocaine-free urinesDrug use
2004
Neural Circuits Underlying Emotional Distress in Humans
SINHA R, LACADIE C, SKUDLARSKI P, WEXLER BE. Neural Circuits Underlying Emotional Distress in Humans. Annals Of The New York Academy Of Sciences 2004, 1032: 254-257. PMID: 15677422, DOI: 10.1196/annals.1314.032.Peer-Reviewed Original ResearchConceptsEmotional distressHealthy volunteersFunctional magnetic resonance imaging (fMRI) techniquesStressful life eventsEmotional stressPosterior cingulate regionsPrefrontal cortical circuitsSubstance use disordersStress processingBrain activationBrain correlatesImagery trialsMedial prefrontalAnterior cingulateLife eventsCingulate regionsMagnetic resonance imaging techniquesParahippocampal gyrusCortical circuitsUse disordersHealthy individualsDistressNeural circuitsSignificant activationClinical samplesVerbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition test
2001
Functional MR imaging of regional brain activation associated with the affective experience of pain.
Fulbright R, Troche C, Skudlarski P, Gore J, Wexler B. Functional MR imaging of regional brain activation associated with the affective experience of pain. American Journal Of Roentgenology 2001, 177: 1205-10. PMID: 11641204, DOI: 10.2214/ajr.177.5.1771205.Peer-Reviewed Original ResearchConceptsAnterior cingulate gyrusSuperior frontal gyrusCingulate gyrusPain taskRight cuneusFunctional MRFrontal gyrusRight superior frontal gyrusBrain activationPain-related activationCold pressor testLeft anterior insulaExperience of painRegional brain activationFunctional MR imagingMotor-sensory areasPainful temperaturesPain thresholdLeft thalamusPressor testPainful levelsPostcentral gyrusPainFrontal lobeHealthy adults
1998
Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging
Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging. JAMA Psychiatry 1998, 55: 1097-1103. PMID: 9862553, DOI: 10.1001/archpsyc.55.12.1097.Peer-Reviewed Original ResearchConceptsSerial position taskFunctional magnetic resonance imagingInferior frontal gyrusPosition taskMemory deficitsFrontal gyrusLeft inferior frontal gyrusAnterior temporal lobe areasTask-specific activationFunctional magnetic resonanceSpeech-related areasCortical hemodynamic responsesTemporal lobe areasSevere cognitive deficitsAuditory wordsWorking memoryVerbal learningNeural basisSuch deficitsCognitive deficitsCognitive functionParietal lobeLobe areasMagnetic resonance imagingCognitive dysfunctionFunctional MR imaging of regional brain responses to pleasant and unpleasant odors.
Fulbright RK, Skudlarski P, Lacadie CM, Warrenburg S, Bowers AA, Gore JC, Wexler BE. Functional MR imaging of regional brain responses to pleasant and unpleasant odors. American Journal Of Neuroradiology 1998, 19: 1721-6. PMID: 9802496, PMCID: PMC8337499.Peer-Reviewed Original ResearchConceptsFunctional MR imagingArea 8BA 6MR imagingBrodmann area 8Human cerebral cortexRegional brain responsesMedial temporal lobeTemporal brain regionsLeft BA 6Independent t-testCerebral cortexTemporal lobeBA 32Cortical areasLeft insulaAnterior temporal brain regionsBrain regionsOrbitofrontal cortexNormal adultsIsovaleric acidOlfactory networkMore activityAir trialsBrain responses
1993
Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function
Levick S, Wexler B, Lorig T, Gur R, Gur R, Schwartz G. Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function. Perceptual And Motor Skills 1993, 76: 1363-1382. PMID: 8337093, DOI: 10.2466/pms.1993.76.3c.1363.Peer-Reviewed Original ResearchConceptsVisual deprivationHemispheric functionCross-modal influencesSpatial orientation taskPerception of pleasantnessLine bisection testVisual attentionVerbal reasoningContact lens methodIntegrated brainOrientation taskLeft hemisphereMood statesEEG thetaMore thetaLateral asymmetryActivation balanceGeneral hypothesisThetaPleasantnessDeprivationHemisphereInput deprivationPerceptionTask
1992
EEG and EMG responses to emotion-evoking stimuli processed without conscious awareness
Wexler B, Warrenburg S, Schwartz G, Janer L. EEG and EMG responses to emotion-evoking stimuli processed without conscious awareness. Neuropsychologia 1992, 30: 1065-1079. PMID: 1484602, DOI: 10.1016/0028-3932(92)90099-8.Peer-Reviewed Original ResearchConceptsConscious awarenessGreater right hemisphere activityEmotion-evoking stimuliEmotion-specific responsesRight hemisphere activityEEG alpha activityRight frontal regionNeutral wordsConscious processingStimulus pairsAuditory perceptsHemisphere activityPositive feelingsFrontal regionsWordsAlpha activityStimuliEEGPerceptAwarenessCorrugatorFeelingsThoughtProcessingEMG responses
1979
Alterations in Cerebral Laterality During Acute Psychotic Illness
Wexler B, Heninger G. Alterations in Cerebral Laterality During Acute Psychotic Illness. JAMA Psychiatry 1979, 36: 278-284. PMID: 33633, DOI: 10.1001/archpsyc.1979.01780030044003.Peer-Reviewed Original ResearchConceptsAcute psychotic illnessHigher lateralityCerebral lateralityPsychotic illnessPrimary major depressive illnessMajor depressive illnessDirect drug effectRight-handed patientsDichotic listening testDepressive illnessControl subjectsDegree of lateralizationNurses' ratingsClinical stateDrug effectsDiagnostic groupsPatientsLateralityIllnessInterindividual differencesPsychotic thoughtWeeksAccuracy of performanceLateralization