2005
Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP. Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms. JAMA Psychiatry 2005, 62: 649-659. PMID: 15939842, DOI: 10.1001/archpsyc.62.6.649.Peer-Reviewed Original ResearchConceptsVisuospatial working memoryWorking memoryAttentional deficitsCognitive deficitsOvernight abstinenceContinuous Performance Test scoresSpatial working memoryOutpatient mental health centersPerformance test scoresCognitive enhancementCPT performanceNeuropsychological assessmentSmoking reinstatementTobacco cravingControl smokersTest scoresCounterbalanced mannerMental health centersCognitive impairmentReinstatementSubjective effectsNicotine dependenceCigarette smokingDeficitsNicotinic receptor mechanisms
2001
Functional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation