2016
Cognitive remediation for adults with schizophrenia: Does age matter?
Corbera S, Wexler BE, Poltorak A, Thime WR, Kurtz MM. Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research 2016, 247: 21-27. PMID: 27863314, PMCID: PMC5248553, DOI: 10.1016/j.psychres.2016.10.084.Peer-Reviewed Original ResearchConceptsCognitive remediationSubstantial individual differencesEarly chronic groupsOlder client populationNovel behavioral interventionSubsample of clientsRole of ageMemory measuresIndividual differencesStrategy acquisitionCognitive outcomesCognitive deficitsTask practiceRandomized control trialBehavioral interventionsTrend levelEmpirical supportSchizophreniaTreatment responseAge matterClient populationEarly-stage groupAge rangeGreater improvementAdultsExecutive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2015
Social skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2012
Neuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity‐based computerized cognitive remediation for geriatric depression. International Journal Of Geriatric Psychiatry 2012, 27: 1239-1247. PMID: 22451346, PMCID: PMC3387346, DOI: 10.1002/gps.3776.Peer-Reviewed Original ResearchConceptsComputerized cognitive remediationCognitive remediationExecutive dysfunctionGeriatric depressionSpecific executive deficitsSpecific neurocognitive deficitsSpecific cerebral networksNovel treatment interventionsAvailable treatment studiesNovel treatment modelExecutive deficitsEmotional regulationNeurocognitive deficitsUnderlying neurobiologyMental health reportsCerebral networksOlder adultsTreatment modelTreatment interventionsDepressed eldersTreatment studiesBehavioral changesNew interventionsDepressionDeficits
2011
Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipants
2008
Predictors of change in life skills in schizophrenia after cognitive remediation
Kurtz MM, Seltzer JC, Fujimoto M, Shagan DS, Wexler BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research 2008, 107: 267-274. PMID: 19006657, PMCID: PMC3399665, DOI: 10.1016/j.schres.2008.10.014.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersComprehensionComputer-Assisted InstructionFemaleHumansInhibition, PsychologicalMemory, Short-TermMiddle AgedNeuropsychological TestsProblem SolvingPrognosisPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceRemedial TeachingSchizophreniaSchizophrenic PsychologySocializationSoftwareVerbal LearningYoung AdultConceptsCognitive remediationAuditory attentionPerformance-based measuresRemediation interventionsComputer-assisted cognitive remediationLife skillsCognitive remediation interventionsSustained auditory attentionEveryday life skillsTreatment-related improvementTreatment process variablesOutpatient rehabilitation treatmentPredictors of changeMeasures of symptomsVerbal abilityVerbal learningTreatment outcome measuresNeurocognitive variablesNeurocognitive functionMemoryNegative symptomsSchizoaffective disorderPredictor studiesCurrent studySchizophreniaNeurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up
Bell MD, Zito W, Greig T, Wexler BE. Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up. Schizophrenia Research 2008, 105: 18-29. PMID: 18715755, DOI: 10.1016/j.schres.2008.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyEmploymentEmployment, SupportedFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsOccupational TherapyPsychiatric Status Rating ScalesPsychotherapy, GroupPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyTreatment OutcomeVocational EducationConceptsNeurocognitive enhancement therapyEnhancement therapyComputer-based cognitive trainingCommunity-based vocational servicesWeekly support groupsCognitive remediationCognitive trainingExecutive functionWork outcomesRemediation programVocational outcomesCommunity mental health centerMental health centersCognitive impairmentSixth quarterVocational servicesNet trainingTherapy outcomeSupport groupsCompetitive employmentSchizophreniaRehabilitation methodsSchizoaffective patientsEmployment programsTrainingNeurocognitive Enhancement Therapy and Competitive Employment in Schizophrenia: Effects on Clients with Poor Community Functioning
BELL M, ZITO W, GREIG T, WEXLER B. Neurocognitive Enhancement Therapy and Competitive Employment in Schizophrenia: Effects on Clients with Poor Community Functioning. American Journal Of Psychiatric Rehabilitation 2008, 11: 109-122. DOI: 10.1080/15487760801963397.Peer-Reviewed Original ResearchNeurocognitive enhancement therapyEnhancement therapyVocational outcomesDiagnosis of schizophreniaCompetitive employmentCompetitive employment ratesTreat sampleHeinrichs QualitySchizoaffective disorderFunctioning patientsTotal hoursTherapy outcomeMore total hoursCommunity functioningLogistic regressionActive interventionLife ScaleOutcomesPatientsTherapyHigh rateCognitive remediationExecutive functionPoor communitiesSchizophrenia
2007
Severe and Persistent Mental Illness
Wexler B, Davidson L, Styron T, Strauss J. Severe and Persistent Mental Illness. 2007, 1-20. DOI: 10.1002/9780470994580.ch1.Chapters
2006
Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient?
Kurtz MM, Seltzer JC, Shagan DS, Thime WR, Wexler BE. Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research 2006, 89: 251-260. PMID: 17070671, PMCID: PMC2095777, DOI: 10.1016/j.schres.2006.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognition DisordersComputer User TrainingComputer-Assisted InstructionFemaleHumansMaleMemory, Short-TermMental RecallMiddle AgedNeuropsychological TestsPattern Recognition, VisualProblem SolvingReaction TimeRemedial TeachingSchizophreniaSchizophrenic LanguageSchizophrenic PsychologySpeech PerceptionConceptsComputer-assisted cognitive remediationTraining control conditionCognitive remediationNeurocognitive functionComprehensive neuropsychological test batteryCognitive remediation interventionsCognitive remediation trainingSpatial episodic memoryControl conditionNeuropsychological test batteryEpisodic memoryComplex behavioral treatmentsBody of researchCognitive stimulationRemediation interventionsCognitive challengesNeurocognitive testsProcessing speedBehavioral treatmentTest batteryMemoryExperimental interventionSchizophreniaNon-specific stimulationIntervention
2005
Cognitive Remediation and Vocational Rehabilitation for Schizophrenia
Wexler BE, Bell MD. Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin 2005, 31: 931-941. PMID: 16079390, DOI: 10.1093/schbul/sbi038.Peer-Reviewed Original ResearchConceptsCognitive remediation treatmentAspects of schizophreniaCognitive remediationCognitive deficitsWork functioningBehavioral interventionsWork therapyCognitionVocational rehabilitationArea of researchLasting improvementMental illnessSchizophreniaMajor mental illnessRemediation treatmentsFunctioningDeficitsInterventionMultiple studiesReadersResearchRehabilitation
2004
Effects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance
Bell MD, Fiszdon J, Bryson G, Wexler BE. Effects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance. Cognitive Neuropsychiatry 2004, 9: 199-211. PMID: 16571581, DOI: 10.1080/13546800344000084.Peer-Reviewed Original ResearchNeurocognitive enhancement therapyMemory taskReaction time taskCognitive remediationTime taskSchizophrenia patientsEnhancement therapyCommunity control samplePreponderance of researchCognitive trainingWord recallDigit recallMemory performanceCognitive performanceCognitive functionSchizophrenia sampleNonpsychiatric controlsTaskReaction timePoor performanceRecallCommunity controlsHierarchical trainingSchizophreniaTrainingDurability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up
Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research 2004, 125: 1-7. PMID: 14967547, DOI: 10.1016/j.psychres.2003.10.004.Peer-Reviewed Original ResearchConceptsCognitive remediation trainingSerial position taskComputerized cognitive remediationDigit span taskSpan taskRemediation trainingCognitive remediationMemory taskPosition taskComputerized cognitive remediation trainingWork therapyActive control conditionGroups of participantsSignificant group differencesComputerized trainingCognitive retrainingComputerized tasksTraining tasksCognitive improvementCognitive deficitsCompletion of trainingGroup differencesControl conditionTaskTraining
2003
Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia
Bell M, Bryson G, Wexler BE. Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia. Acta Psychiatrica Scandinavica 2003, 108: 101-109. PMID: 12823166, DOI: 10.1034/j.1600-0447.2003.00090.x.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyCognitive remediationTraining effectsSocial information processingCognitive training exercisesExecutive functionMemory performanceEnhancement therapyMemory deficitsInformation processingSeverity of impairmentDuration of trainingGreater improvementSchizoaffective disorderMemoryParticipantsTraining exercisesMost participantsImpairment severitySchizophreniaTrainingDuration of effectSeverity groupsDeficitsNormalization of working memory in schizophrenia following cognitive remediation: Durability of effects
Fiszdon J, Bryson G, Wexler B, Bell M. Normalization of working memory in schizophrenia following cognitive remediation: Durability of effects. Schizophrenia Research 2003, 60: 322. DOI: 10.1016/s0920-9964(03)80282-7.Peer-Reviewed Original Research