2022
Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits
Romans RA, Lu JC, Balasubramanian S, Whiteside W, Yu S, Aldoss OT, Armstrong AK, Boe BA, Balzer DT, Christensen JT, Jones TK, Keeshan B, McLennan D, Nicholson GT, Patel N, Salavitabar A, Shahanavaz S, Sullivan PM, Turner ME, Zampi JD. Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits. JACC Cardiovascular Interventions 2022, 15: 979-988. PMID: 35512922, DOI: 10.1016/j.jcin.2022.02.047.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve implantationCardiac magnetic resonanceRV-PA conduitCA compressionCoronary artery compressionPulmonary valve implantationArtery compressionValve implantationCoronary anatomyBalloon testingStenotic areaAbnormal coronary anatomyPulmonary artery conduitInstitutional review board approvalDysfunctional right ventricleReview board approvalNegative predictive valueConduit calcificationArtery conduitAbsolute contraindicationPatient selectionRight ventricleSubjective assessmentCMR studiesBoard approval
2020
Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis
Shahanavaz S, Zahn EM, Levi DS, Aboulhousn JA, Hascoet S, Qureshi AM, Porras D, Morgan GJ, Bauser Heaton H, Martin MH, Keeshan B, Asnes JD, Kenny D, Ringewald JM, Zablah JE, Ivy M, Morray BH, Torres AJ, Berman DP, Gillespie MJ, Chaszczewski K, Zampi JD, Walsh KP, Julien P, Goldstein BH, Sathanandam SK, Karsenty C, Balzer DT, McElhinney DB. Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis. Journal Of The American College Of Cardiology 2020, 76: 2847-2858. PMID: 33303074, DOI: 10.1016/j.jacc.2020.10.041.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve replacementPulmonary valve replacementSAPIEN XTValve replacementS3 valveMost patientsShort-term outcome dataGreater pulmonary regurgitationMaximum Doppler gradientOutflow tract anatomyTricuspid valve injurySAPIEN 3 valveSerious adverse eventsBalloon-expandable valveShort-term outcomesSurgical valve replacementValve complicationsMulticenter registryUrgent surgeryAdverse eventsDoppler gradientPulmonary regurgitationSAPIEN prosthesisTotal patientsValve injuryOutcomes of Adults with Congenital Heart Disease Supported with Extracorporeal Life Support After Cardiac Surgery.
Dolgner SJ, Keeshan BC, Burke CR, McMullan DM, Chan T. Outcomes of Adults with Congenital Heart Disease Supported with Extracorporeal Life Support After Cardiac Surgery. ASAIO Journal 2020, 66: 1096-1104. PMID: 33136596, DOI: 10.1097/mat.0000000000001141.Peer-Reviewed Original ResearchConceptsExtracorporeal life supportAdult congenital heart diseaseFontan physiologyCardiac surgeryCongenital heart diseaseRisk factorsACHD patientsNeurologic complicationsHeart diseaseExtracorporeal Life Support Organization databaseLife supportMulticenter international registryOutcomes of adultsMultivariate logistic regressionECLS centersECLS useRenal complicationsECLS supportOverall mortalityPulmonary hemorrhageCardiopulmonary supportNeuromuscular blockadeInternational registryECLS cannulationFemale gender
2018
Transcatheter Pulmonary Valve Replacement With the Melody Valve in Small Diameter Expandable Right Ventricular Outflow Tract Conduits
Shahanavaz S, Qureshi AM, Levi DS, Boudjemline Y, Peng LF, Martin MH, Bauser-Heaton H, Keeshan B, Asnes JD, Jones TK, Justino H, Aboulhosn JA, Gray RG, Nguyen H, Balzer DT, McElhinney DB. Transcatheter Pulmonary Valve Replacement With the Melody Valve in Small Diameter Expandable Right Ventricular Outflow Tract Conduits. JACC Cardiovascular Interventions 2018, 11: 554-564. PMID: 29566801, DOI: 10.1016/j.jcin.2018.01.239.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAngiographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCardiac CatheterizationChildChild, PreschoolFeasibility StudiesFemaleGraft Occlusion, VascularHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansMalePreliminary DataProsthesis DesignPulmonary ValveRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Outflow ObstructionYoung AdultConceptsTranscatheter pulmonary valve replacementRight ventricular outflow tractPulmonary valve replacementMelody valveValve replacementDysfunctional right ventricular outflow tractsPercutaneous transcatheter pulmonary valve replacementSuccessful transcatheter pulmonary valve replacementSignificant hemodynamic improvementSignificant pulmonary regurgitationVentricular outflow tractCases of endocarditisRVOT reinterventionHemodynamic improvementPulmonary regurgitationHemodynamic outcomesOutflow tractProcedural characteristicsPreliminary experiencePatientsSmall diameter conduitsLimited dataOutcomesSmall conduitsReintervention
2017
Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients
Keeshan BC, O'Connor MJ, Lin KY, Monos D, Lind C, Mascio CE, Rame JE, Spray TL, Shaddy RE, Rossano JW. Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients. Clinical Transplantation 2017, 31 PMID: 28766759, DOI: 10.1111/ctr.13064.Peer-Reviewed Original ResearchConceptsHeart transplant recipientsGraft survivalPositive FCXMHeart transplantationTransplant recipientsT cellsB cellsNegative complement-dependent cytotoxicityCox proportional hazard modelingDecreased graft survivalOrgan Sharing databaseHLA-specific antibodiesKaplan-Meier analysisCross-match resultsProportional hazard modelingDifferent patient cohortsComplement-dependent cytotoxicityXM patientsGraft failureSharing databaseUnited NetworkPatient cohortInclusion criteriaCross matchClinical relevance
2015
Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database
O'Connor MJ, Keeshan BC, Lin KY, Monos D, Lind C, Paridon SM, Mascio CE, Shaddy RE, Rossano JW. Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database. Clinical Transplantation 2015, 29: 842-850. PMID: 26172275, DOI: 10.1111/ctr.12590.Peer-Reviewed Original ResearchConceptsPanel reactive antibodyHuman leukocyte antibodiesOrgan Sharing databaseHeart transplantationReactive antibodiesGraft lossLeukocyte antibodiesSharing databaseUnited NetworkAntibody assessmentFlow cytometryClass IPre-transplant patientsUnderwent heart transplantationTime of transplantationPrimary outcome measureFlow cytometric assessmentGraft survivalMultivariable analysisOutcome measuresTransplantationCytometric assessmentPatientsStudy periodAntibodies
2014
Lung transplant waitlist mortality: Height as a predictor of poor outcomes
Keeshan BC, Rossano JW, Beck N, Hammond R, Kreindler J, Spray TL, Fuller S, Goldfarb S. Lung transplant waitlist mortality: Height as a predictor of poor outcomes. Pediatric Transplantation 2014, 19: 294-300. PMID: 25406495, DOI: 10.1111/petr.12390.Peer-Reviewed Original ResearchConceptsLung allocation systemWaitlist mortalityPretransplant mortalityCurrent lung allocation systemPost-transplant outcomesPost-transplant survivalTime of listingLung transplantUNOS databaseIndependent predictorsPediatric patientsPoor outcomeMale genderRetrospective analysisWait listAge cutoffMultivariate analysisMortalityPatientsPredictorsValuable factorShorter heightOutcomesAllocation systemUnited States
2013
Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation
Keeshan BC, Goldfarb SB, Lin KY, Kreindler JL, Kaufman BD, Gaynor JW, Shaddy RE, Rossano JW. Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation. Pediatric Transplantation 2013, 18: 204-210. PMID: 24373099, DOI: 10.1111/petr.12208.Peer-Reviewed Original ResearchConceptsPediatric heart-lung transplantationPretransplant mechanical ventilationWorse graft survivalHeart-lung transplantationComplex patient populationCongenital heart diseaseDiagnosis of CHDPretransplant PRATransplant eraGraft survivalPreoperative factorsUNOS databaseGraft failureMechanical ventilationMultivariable analysisWorse prognosisPatient survivalPoor outcomeCardiopulmonary diseasePatient populationAlternative therapiesHeart diseaseRetrospective analysisYounger ageCHD