Britton Keeshan, MD, MPH
Associate Professor of PediatricsCards
About
Research
Publications
2023
Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia
Sasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.Peer-Reviewed Case Reports and Technical Notes
2022
Health Care Disparities in Congenital Cardiology: Considerations Through the Lens of an Interventional Cardiologist
Bauser-Heaton H, Aggarwal V, Graziano J, Ligon R, Keeshan B, Stapleton G, Sutton N, Fleming G, El-Said H, Kim D, Ing F. Health Care Disparities in Congenital Cardiology: Considerations Through the Lens of an Interventional Cardiologist. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100388. PMID: 39131467, PMCID: PMC11308374, DOI: 10.1016/j.jscai.2022.100388.Peer-Reviewed Original ResearchCardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits
Romans RA, Lu JC, Balasubramanian S, Whiteside W, Yu S, Aldoss OT, Armstrong AK, Boe BA, Balzer DT, Christensen JT, Jones TK, Keeshan B, McLennan D, Nicholson GT, Patel N, Salavitabar A, Shahanavaz S, Sullivan PM, Turner ME, Zampi JD. Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits. JACC Cardiovascular Interventions 2022, 15: 979-988. PMID: 35512922, DOI: 10.1016/j.jcin.2022.02.047.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve implantationCardiac magnetic resonanceRV-PA conduitCA compressionCoronary artery compressionPulmonary valve implantationArtery compressionValve implantationCoronary anatomyBalloon testingStenotic areaAbnormal coronary anatomyPulmonary artery conduitInstitutional review board approvalDysfunctional right ventricleReview board approvalNegative predictive valueConduit calcificationArtery conduitAbsolute contraindicationPatient selectionRight ventricleSubjective assessmentCMR studiesBoard approvalPulmonary Stenosis
Keeshan B, Asnes J. Pulmonary Stenosis. BMJ Best Practice. Dec. 2022. https://bestpractice.bmj.com/topics/en-us/475Chapters
2021
Racial and ethnic disparities in coronary, vascular, structural, and congenital heart disease
Grines CL, Klein AJ, Bauser‐Heaton H, Alkhouli M, Katukuri N, Aggarwal V, Altin SE, Batchelor WB, Blankenship JC, Fakorede F, Hawkins B, Hernandez GA, Ijioma N, Keeshan B, Li J, Ligon RA, Pineda A, Sandoval Y, Young MN. Racial and ethnic disparities in coronary, vascular, structural, and congenital heart disease. Catheterization And Cardiovascular Interventions 2021, 98: 277-294. PMID: 33909339, DOI: 10.1002/ccd.29745.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTranscatheter aortic valve replacementNon-Hispanic whitesCardiovascular diseaseCongenital heart interventionsInterventional cardiovascular therapyAortic valve replacementCongenital heart diseaseRate of diagnosisCause of deathInterventional cardiology patientsPrevalence of diseaseTAVR patientsValve replacementExcess morbidityTreatment disparitiesCardiology patientsHeart diseaseCardiovascular AngiographyClinical careAverage ageCardiovascular therapyPatientsHeart interventionsEthnic disparitiesUnderserved populations
2020
Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis
Shahanavaz S, Zahn EM, Levi DS, Aboulhousn JA, Hascoet S, Qureshi AM, Porras D, Morgan GJ, Bauser Heaton H, Martin MH, Keeshan B, Asnes JD, Kenny D, Ringewald JM, Zablah JE, Ivy M, Morray BH, Torres AJ, Berman DP, Gillespie MJ, Chaszczewski K, Zampi JD, Walsh KP, Julien P, Goldstein BH, Sathanandam SK, Karsenty C, Balzer DT, McElhinney DB. Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis. Journal Of The American College Of Cardiology 2020, 76: 2847-2858. PMID: 33303074, DOI: 10.1016/j.jacc.2020.10.041.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve replacementPulmonary valve replacementSAPIEN XTValve replacementS3 valveMost patientsShort-term outcome dataGreater pulmonary regurgitationMaximum Doppler gradientOutflow tract anatomyTricuspid valve injurySAPIEN 3 valveSerious adverse eventsBalloon-expandable valveShort-term outcomesSurgical valve replacementValve complicationsMulticenter registryUrgent surgeryAdverse eventsDoppler gradientPulmonary regurgitationSAPIEN prosthesisTotal patientsValve injuryThe Role of Novel Transcatheter Procedures in Patients With Congenital Heart Disease
Joffe D, Sheu R, Keeshan B, Burbano-Vera N. The Role of Novel Transcatheter Procedures in Patients With Congenital Heart Disease. Journal Of Cardiothoracic And Vascular Anesthesia 2020, 35: 2180-2193. PMID: 32758406, DOI: 10.1053/j.jvca.2020.07.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOutcomes of Adults with Congenital Heart Disease Supported with Extracorporeal Life Support After Cardiac Surgery.
Dolgner SJ, Keeshan BC, Burke CR, McMullan DM, Chan T. Outcomes of Adults with Congenital Heart Disease Supported with Extracorporeal Life Support After Cardiac Surgery. ASAIO Journal 2020, 66: 1096-1104. PMID: 33136596, DOI: 10.1097/mat.0000000000001141.Peer-Reviewed Original ResearchConceptsExtracorporeal life supportAdult congenital heart diseaseFontan physiologyCardiac surgeryCongenital heart diseaseRisk factorsACHD patientsNeurologic complicationsHeart diseaseExtracorporeal Life Support Organization databaseLife supportMulticenter international registryOutcomes of adultsMultivariate logistic regressionECLS centersECLS useRenal complicationsECLS supportOverall mortalityPulmonary hemorrhageCardiopulmonary supportNeuromuscular blockadeInternational registryECLS cannulationFemale gender
2019
OUTCOMES OF ADULTS WITH CONGENITAL HEART DISEASE SUPPORTED WITH EXTRACORPOREAL LIFE SUPPORT AFTER CARDIAC SURGERY
Dolgner S, Keeshan B, Burke C, McMullan D, Chan T. OUTCOMES OF ADULTS WITH CONGENITAL HEART DISEASE SUPPORTED WITH EXTRACORPOREAL LIFE SUPPORT AFTER CARDIAC SURGERY. Journal Of The American College Of Cardiology 2019, 73: 3077. DOI: 10.1016/s0735-1097(19)33683-6.Peer-Reviewed Original Research
2018
(1020) Duration of ECMO Support Predicts Survival in Transplant Patients
Grijalva J, Keeshan B, Dentel J, Chen J, McMullan D. (1020) Duration of ECMO Support Predicts Survival in Transplant Patients. The Journal Of Heart And Lung Transplantation 2018, 37: s397. DOI: 10.1016/j.healun.2018.01.1023.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Britton C. Keeshan MD, MPH, is a pediatric cardiologist who treats congenital heart disease in adults and children and says he is constantly inspired by his patients.
“Some of the children we treat have been through so much, maybe three or even four congenital heart surgeries. They’ve spent significant periods of their lives in the hospital,” Dr. Keeshan says. “They are some of the most resilient, special kids you’ll ever meet.”
Dr. Keeshan specializes in diagnostic and interventional cardiac catheterization, which involves inserting a thin, flexible tube (called a catheter) into a blood vessel (typically in the leg) and threading it up to the heart. Doctors can then perform imaging tests and certain procedures in a minimally invasive way (meaning without the need for traditional open surgery).
“We can get our catheters to various positions in the heart and do things as simple as measuring pressure and oxygen saturation or thread a small ultrasound probe,” Dr. Keeshan says. “We can actually take pictures of a person’s heart defect from within the heart itself.”
The advances in his field have been immense and continue at an exciting rate, he says. “If you asked someone who performed catheterization 20 years ago where we’d be today, they’d be incredibly impressed with the technology,” he says. “Now, we’re performing advanced surgical techniques on newborns, and they are living well into adulthood.”
Dr. Keeshan is an assistant professor of clinical pediatrics at Yale School of Medicine.
Clinical Specialties
Fact Sheets
Pediatric Congenital Heart Surgery
Learn More on Yale MedicinePulmonary Stenosis
Learn More on Yale MedicinePatent Ductus Arteriosus (PDA)
Learn More on Yale MedicineAtrial Septal Defect (ASD)
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