2003
Systemic Tropheryma whippleii infection associated with monoclonal B-cell proliferation: a Helicobacter pylori-type pathogenesis?
Wang S, Ernst LM, Smith BR, Tallini G, Howe JG, Crouch J, Cooper DL. Systemic Tropheryma whippleii infection associated with monoclonal B-cell proliferation: a Helicobacter pylori-type pathogenesis? Archives Of Pathology & Laboratory Medicine 2003, 127: 1619-22. PMID: 14632565, DOI: 10.5858/2003-127-1619-stwiaw.Peer-Reviewed Original ResearchConceptsMonoclonal B-cell proliferationLymph nodesB cell proliferationWhipple's diseasePeripheral bloodPolymerase chain reactionB cellsRight axillary lymph nodeAxillary lymph nodesMesenteric lymph nodesMonoclonal B-cell populationTime of presentationPatients' peripheral bloodPrevious biopsy specimensChain reactionB-cell lymphomaMonoclonal B cellsB cell populationsPeriodic acid-Schiff stainFlow cytometry studiesRoutine cytogenetic studiesEntire followMesenteric lymphBiopsy specimensImmunohistochemical stains
1999
Use of rituximab and irradiated donor-derived lymphocytes to control Epstein–Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation
McGuirk J, Seropian S, Howe G, Smith B, Stoddart L, Cooper D. Use of rituximab and irradiated donor-derived lymphocytes to control Epstein–Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation. Bone Marrow Transplantation 1999, 24: 1253-1258. PMID: 10642818, DOI: 10.1038/sj.bmt.1702052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAntigens, ViralAntineoplastic AgentsBlood Component TransfusionBlood DonorsDNA, ViralGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHerpesvirus 4, HumanHumansImmunosuppression TherapyLymphocytesLymphoproliferative DisordersMalePolymerase Chain ReactionRituximabConceptsEpstein-Barr virus-associated lymphoproliferative disorderStem cell transplantationEBV DNA titersB cell populationsCell transplantationTherapeutic strategiesEpstein-Barr virus-associated lymphoproliferationHaplo-identical stem cell transplantationEffective alternative therapeutic strategyAllogeneic stem cell transplantationCourses of rituximabDonor-derived lymphocytesPost-transplant immunosuppressionMonoclonal B-cell populationCD20 monoclonal antibodyCell populationsAlternative therapeutic strategiesImmunosuppressive medicationsSevere GVHDHost diseaseLymphocyte infusionPost transplantFatal complicationCurative therapyLymphoproliferative disorders
1993
Integrating Flow Cytometry in the Hematology Laboratory
SMITH B. Integrating Flow Cytometry in the Hematology Laboratory. Annals Of The New York Academy Of Sciences 1993, 677: 326-333. PMID: 8494218, DOI: 10.1111/j.1749-6632.1993.tb38787.x.Peer-Reviewed Original ResearchAntigens, CDFlow CytometryHematologyHIV InfectionsHumansImmunophenotypingLeukemiaLymphocytesLymphoproliferative Disorders
1991
Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.Peer-Reviewed Original ResearchConceptsAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patients
1990
Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells.
Strair R, Towle M, Heald P, Smith B. Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells. Blood 1990, 76: 1201-8. PMID: 2144777, DOI: 10.1182/blood.v76.6.1201.bloodjournal7661201.Peer-Reviewed Original ResearchConceptsAdenovirus E2 promoterBeta-galactosidase geneLymphoid cellsE2 promoterRecombinant retrovirusPrimary lymphoid cellsPrimary cellsSpecific cell typesViral gene productsLymphoproliferative disordersBeta-galactosidase activityGene productsMalignant cellsSimilar infectionsExogenous genesExogenous promoterTransactivator activityCell typesPromoterGenesInfectionRetrovirusesCellsExpressionPatients
1989
Monoclonal and oligoclonal gammopathy after bone marrow transplantation.
Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and oligoclonal gammopathy after bone marrow transplantation. Blood 1989, 74: 2764-8. PMID: 2819246, DOI: 10.1182/blood.v74.8.2764.bloodjournal7482764.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBone Marrow TransplantationGraft vs Host DiseaseHumansHypergammaglobulinemiaLymphoproliferative DisordersMonoclonal Gammopathy of Undetermined SignificanceTime FactorsConceptsBone marrow transplantationMonoclonal gammopathyMarrow transplantationSyngeneic bone marrow transplantationM-componentEarly B cell ontogenySerum protein electrophoresesSyngeneic graft recipientsT lymphocyte subsetsDevelopment of graftImmunoglobulin G typeB cell populationsOligoclonal gammopathyPatients posttransplantationDays posttransplantationHost diseaseGraft recipientsB cell ontogenyGammopathyTransplantationPosttransplantationPatientsUbiquitous findingCorrelation of recoveryG-typeFlow cytometric surface light chain analysis of lymphocyte‐rich effusions. A useful adjunct to cytologic diagnosis
Ibrahim R, Teich D, Smith B, Antin J, Olivier A, Weinberg D. Flow cytometric surface light chain analysis of lymphocyte‐rich effusions. A useful adjunct to cytologic diagnosis. Cancer 1989, 63: 2024-2029. PMID: 2495164, DOI: 10.1002/1097-0142(19890515)63:10<2024::aid-cncr2820631026>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsLymphocyte-rich effusionsLight chain analysisCytologic diagnosisFalse-positive resultsCytologic studyFalse negative rateCell marker studiesSmall lymphocytic lymphomaBody cavity fluidsClinical outcomesLymphoproliferative disordersLymphocytic lymphomaLymphatic leukemiaCytologic evaluationSmall lymphocytesCytologic analysisBenign effusionsUseful adjunctClinical diagnosisPatientsEffusionLymphomaDiagnosisMarker studiesCavity fluid
1984
Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma
Smith B, Weinberg D, Robert N, Towle M, Luther E, Pinkus G, Ault K. Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma. New England Journal Of Medicine 1984, 311: 1476-1481. PMID: 6438505, DOI: 10.1056/nejm198412063112304.Peer-Reviewed Original ResearchConceptsMonoclonal B lymphocytesMonoclonal lymphocytesLight chain typeB lymphocytesHodgkin's lymphomaSensitive flow cytometric methodBone marrow involvementDiffuse histiocytic lymphomaProlonged clinical remissionNon-Hodgkin lymphomaForms of lymphomaCategory of lymphomaClinical remissionComplete remissionFlow cytometric methodClinical stagingProlonged remissionsHistologic subclassificationPrognostic importanceHistiocytic lymphomaRemissionPatient's diseasePatientsLymphomaClonal excess