1997
Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender
Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassOlder patientsT cellsLower lymphocyte numbersPercentage of CD8Total lymphocyte countCardiac surgery patientsPostoperative day 1Age of patientsMononuclear cell subsetsNatural killer cellsExpression of CD11bPatterns of lymphocytesYears of ageEvidence of activationHLADR expressionInfectious complicationsLymphocyte subsetsElderly patientsLymphocyte countSurgery patientsYounger patientsCardiac surgeryLymphocyte numbersKiller cells
1995
Natural killer cell lymphoproliferative disease associated with neuropathy
Leitenberg D, Eisen R, Goldstein J, Busque L, Rinder H, Stys P, Katz M, Gilliland D, Smith B. Natural killer cell lymphoproliferative disease associated with neuropathy. The American Journal Of Medicine 1995, 99: 99-101. PMID: 7598151, DOI: 10.1016/s0002-9343(99)80112-0.Peer-Reviewed Original ResearchAgedBiopsyFemaleHumansKiller Cells, NaturalLymphocytosisMalePeripheral Nervous System DiseasesSural NerveLymphocyte adhesion-dependent calcium signaling in human endothelial cells.
Pfau S, Leitenberg D, Rinder H, Smith BR, Pardi R, Bender JR. Lymphocyte adhesion-dependent calcium signaling in human endothelial cells. Journal Of Cell Biology 1995, 128: 969-978. PMID: 7533170, PMCID: PMC2120392, DOI: 10.1083/jcb.128.5.969.Peer-Reviewed Original ResearchConceptsEC Ca2Endothelial cellsEC alterationsLymphocyte-endothelial interactionsNatural killer cellsImmune effector cellsTumor necrosis factorHuman umbilical vein endothelial cellsCytosolic free calcium changesUmbilical vein endothelial cellsVascular endothelial cellsHuman umbilical vein ECsAllogeneic CD3Lymphocyte subsetsVein endothelial cellsHuman endothelial cellsNK cellsEffector cellsKiller cellsVascular toneInflammatory responseNecrosis factorSecond messenger pathwaysExtracellular influxCytokine activation
1993
Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation
Macklis R, Mauch P, Thompson L, Burakoff S, Smith B. Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation. Oncology 1993, 50: 323-328. PMID: 8497384, DOI: 10.1159/000227203.Peer-Reviewed Original ResearchMeSH KeywordsCytotoxicity Tests, ImmunologicFlow CytometryHodgkin DiseaseHumansImmunophenotypingKiller Cells, NaturalLymphatic IrradiationConceptsNK cell subsetsNK cell compartmentHodgkin's disease patientsDisease patientsLymphoid irradiationNK cellsCell subsetsNatural killer cell subpopulationsSpecific NK cell subsetsLong-term immunosuppressionNK cell assaysCell compartmentSignificant changesCell subpopulationsPatientsCytometric cell sortingLytic activityCell assayImmunophenotypeCell sortingCytotoxicity spectrumImmunosuppressionCellsSubsetCompartments
1992
A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity.
Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.Peer-Reviewed Original ResearchConceptsNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locus
1989
Hematopoiesis in vitro coexists with natural killer lymphocytes.
Niemeyer C, Sieff C, Smith B, Ault K, Nathan D. Hematopoiesis in vitro coexists with natural killer lymphocytes. Blood 1989, 74: 2376-82. PMID: 2529928, DOI: 10.1182/blood.v74.7.2376.bloodjournal7472376.Peer-Reviewed Original ResearchConceptsBlood NK cellsNatural killerNK cellsInterleukin-2Colony formationMarrow progenitorsInhibition of MyeloidK562 target cellsNatural killer lymphocytesCell populationsCD16 positive lymphocytesMarrow cell populationsPositive lymphocytesHematopoietic progenitor cellsKiller lymphocytesCell ratioProgenitor cell populationsLymphocytesTarget cellsProgenitor cellsCell sorterInhibitionHuman hematopoiesisDisparate findingsCell lineages
1985
Phenotype of recovering lymphoid cell populations after marrow transplantation.
Ault KA, Antin JH, Ginsburg D, Orkin SH, Rappeport JM, Keohan ML, Martin P, Smith BR. Phenotype of recovering lymphoid cell populations after marrow transplantation. Journal Of Experimental Medicine 1985, 161: 1483-1502. PMID: 3159819, PMCID: PMC2187630, DOI: 10.1084/jem.161.6.1483.Peer-Reviewed Original ResearchNatural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity.
Smith BR, Rosenthal DS, Ault KA. Natural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity. Experimental Hematology 1985, 13: 189-93. PMID: 3884356.Peer-Reviewed Original ResearchConceptsHairy cell leukemiaNK cellsNatural killerFluorescence-activated cell sorterNK activityNK functionCell leukemiaFunctional deficiencyNormal numbersPhenotypic NK cellsMajority of patientsStandard 51Cr releaseSevere functional deficiencyDefective functional activityK562 targetsNK populationPatientsSurface markersK562 cell lineFunctional activityCell populationsCell sorterCell linesLeukemiaIdentifiable cells