2020
Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival
Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.Peer-Reviewed Original Research
2018
False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab
Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.Peer-Reviewed Original ResearchConceptsHealthy donor bloodAlemtuzumab treatmentDonor bloodBone marrowFlow cytometryLight chain restrictionT-cell prolymphocytic leukemiaB-cell neoplasmsLight chain clonalityFlow cytometry analysisAutoimmune diseasesHematologic malignanciesImmunophenotypic analysisChain restrictionAlemtuzumabT cellsB cellsProlymphocytic leukemiaImmunoglobulin G1PatientsMonoclonal antibodiesCytometry analysisSimilar findingsBloodClonal restriction
2016
Laboratory Medicine Education at U.S. Medical Schools
Smith BR, Kamoun M, Hickner J. Laboratory Medicine Education at U.S. Medical Schools. Academic Medicine 2016, 91: 107-112. PMID: 26200574, PMCID: PMC5480607, DOI: 10.1097/acm.0000000000000817.Peer-Reviewed Original ResearchConceptsLaboratory medicine educationU.S. medical schoolsMedicine educationMedical schoolsCourse workNational standardized examinationsProblem-based learningPreclinical curriculumCurriculum guidelinesStudent competenciesStudent interestClinical curriculumEducation directorsMedical educationMedicine curriculumLack of knowledgeCurriculumLiaison CommitteeSchoolsEducationCompetency assessmentDepartment chairsLaboratory sessionsStandardized examinationCompetencies
2015
Biosimilar biologics: never identical but close enough
Abi‐Raad R, Smith BR. Biosimilar biologics: never identical but close enough. Transfusion 2015, 55: 229-231. PMID: 25683185, DOI: 10.1111/trf.12961.Peer-Reviewed Original Research
2014
In reply
Tormey CA, Smith BR. In reply. Transfusion 2014, 54: 1441-1442. PMID: 24819077, DOI: 10.1111/trf.12587.Peer-Reviewed Original ResearchBlood TransfusionHumans
2012
The transfusion medicine specialist as a coagulation consultant: a new variant of therapeutic pathology
Tormey CA, Smith BR. The transfusion medicine specialist as a coagulation consultant: a new variant of therapeutic pathology. Transfusion 2012, 53: 2086-2093. PMID: 23228202, DOI: 10.1111/trf.12012.Peer-Reviewed Original ResearchConceptsTransfusion medicine practitionersMedicine practitionersTransfusion medicineLaboratory coagulation testingRegular clinical practicePatient managementClinical roleCoagulation testingClinical practiceClinical issuesHemostasisShortage of specialistsField of hemostasisConsultationNovel curriculumMedicineThrombosisPathology Resident and Fellow Education in a Time of Disruptive Technologies
Ziai JM, Smith BR. Pathology Resident and Fellow Education in a Time of Disruptive Technologies. Clinics In Laboratory Medicine 2012, 32: 623-638. PMID: 23078663, DOI: 10.1016/j.cll.2012.07.004.Peer-Reviewed Original ResearchConceptsTraditional educational paradigmFellow educationPractice modelEducational paradigmPractice aspectsTraining programHeuristic needsDisruptive technologiesPathology residentsEducationMedical knowledgeInnovative methodologyPractice of pathologyNew medical knowledgeTechnologyTrainingProgramPracticeFutureExpertiseKnowledgeImplementationQuestionsNeedArticleNormalized CCND1 expression has prognostic value in mantle cell lymphoma
Siddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-553. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.Peer-Reviewed Original ResearchUtility of peripheral blood flow cytometry in differentiating low grade versus high grade myelodysplastic syndromes (MDS) and in the evaluation of cytopenias.
Rashidi HH, Xu X, Wang HY, Shafi NQ, Rameshkumar K, Messer K, Smith BR, Rose MG. Utility of peripheral blood flow cytometry in differentiating low grade versus high grade myelodysplastic syndromes (MDS) and in the evaluation of cytopenias. International Journal Of Clinical And Experimental Pathology 2012, 5: 224-30. PMID: 22558477, PMCID: PMC3341683.Peer-Reviewed Original ResearchConceptsHigh-grade myelodysplastic syndromeChronic myelomonocytic leukemiaPeripheral blood flow cytometryEvaluation of cytopeniasBlood flow cytometryMyelodysplastic syndromeFlow cytometryDifferential diagnosisHigh-risk myelodysplastic syndromeLow-grade myelodysplastic syndromesRisk myelodysplastic syndromesCMML patientsMyelomonocytic leukemiaDiagnostic utilityCytopeniasPatientsCytometrySyndromeLow gradeDiagnosisLeukemia
2010
Educating Medical Students in Laboratory Medicine
Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY. Educating Medical Students in Laboratory Medicine. American Journal Of Clinical Pathology 2010, 133: 533-542. PMID: 20231605, DOI: 10.1309/ajcpqct94sferlni.Peer-Reviewed Original ResearchConceptsMedical student educationMedical school facultyClinical Laboratory PhysiciansCurriculum committeeStudent educationSuggested curriculumInstructional methodsFlexner ReportSchool facultyMedicine curriculumMedical studentsCurriculumAdequacy of trainingAreas of concernHelpful outlineNational health care organizationsTrainingLaboratory physiciansStudentsEducationFacultyDisciplinesAcademyEntire membershipTopic
2009
2008 ACLPS Panel Discussion on Resident Education in Clinical Pathology
Prak E, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR. 2008 ACLPS Panel Discussion on Resident Education in Clinical Pathology. American Journal Of Clinical Pathology 2009, 131: 618-622. PMID: 19369619, DOI: 10.1309/ajcppi03hmyaaeoj.Peer-Reviewed Original ResearchThe utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: A prospective study
Truong F, Smith BR, Stachurski D, Cerny J, Medeiros LJ, Woda BA, Wang A. The utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: A prospective study. Leukemia Research 2009, 33: 1039-1046. PMID: 19232722, DOI: 10.1016/j.leukres.2009.01.012.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeCytopenic patientsFlow cytometricPredictive valueGroup 1 patientsGroup 2 patientsHematology outpatient clinicBone marrow aspirateNegative predictive valuePositive predictive valueFCM resultsMedian followMyelomonocytic maturationAbnormal cytogeneticsBM examinationBM diseaseClinical entityOutpatient clinicProspective studyMedical causesMorphological dysplasiaClinical managementMarrow aspiratesIdiopathic cytopeniaPatients
2008
Therapeutic pathology: time to move beyond diagnostics
Smith BR. Therapeutic pathology: time to move beyond diagnostics. Human Pathology 2008, 39: 1725-1727. PMID: 18656233, DOI: 10.1016/j.humpath.2008.04.004.Peer-Reviewed Original ResearchMeeting the curriculum needs for different career paths in Laboratory Medicine
Smith BR. Meeting the curriculum needs for different career paths in Laboratory Medicine. Clinica Chimica Acta 2008, 393: 5-8. PMID: 18410745, PMCID: PMC2467462, DOI: 10.1016/j.cca.2008.03.019.Peer-Reviewed Original ResearchConceptsCareer pathsCurrent pedagogical approachesChallenges of educationDiverse career pathsClinical Laboratory PhysiciansPost-graduate levelDifferent career pathsClinical practice modelPedagogical approachDidactic methodologyMedical studentsCompetency assessmentCurrent trainingCurriculumPractice modelDisciplinesLaboratory physiciansStudentsEducationNeedTrainingLaboratory medicineMajor emphasisPracticeAcademyDNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemia
Kenney B, Zieske A, Rinder H, Smith B. DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemia. Leukemia & Lymphoma 2008, 49: 42-48. PMID: 18203010, DOI: 10.1080/10428190701760052.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaDetection of relapseDNA ploidy analysisLymphoblastic leukemiaPloidy analysisB-lineageB-lineage acute lymphoblastic leukemiaCytometric DNA ploidy analysisDiagnosis of relapseNormal precursor B cellsPrecursor B cellsOriginal immunophenotypeRelapsed diseaseUnique immunophenotypeLeukemic immunophenotypesImmunophenotypic detectionRelapseB cellsPatientsImmunophenotypeFlow immunophenotypingFlow cytometryAneuploid populationsDiagnosisLeukemia
2007
Monocyte Activation in On-Pump Versus Off-Pump Coronary Artery Bypass Surgery
Greilich PE, Brouse CF, Rinder HM, Jessen ME, Rinder CS, Eberhart RC, Whitten CW, Smith BR. Monocyte Activation in On-Pump Versus Off-Pump Coronary Artery Bypass Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2007, 22: 361-368. PMID: 18503922, DOI: 10.1053/j.jvca.2007.08.009.Peer-Reviewed Original ResearchConceptsPump CABG surgeryCABG surgeryMonocyte activationPump CABGPump Versus Off-Pump Coronary Artery Bypass SurgeryOff-pump coronary artery bypass surgeryPump coronary artery bypass graft surgeryCoronary artery bypass graft surgeryOff-pump CABG surgeryArtery bypass graft surgeryCoronary artery bypass surgeryMonocyte CD11b expressionPrimary CABG surgeryBypass graft surgeryArtery bypass surgerySystemic inflammatory responseVeterans Affairs hospitalInterleukin levelsSurgery warrantsGraft surgeryAdverse eventsBypass surgeryHeparin reversalPathophysiologic differencesAntifibrinolytic agentsFlow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang A. Flow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls. Leukemia Research 2007, 32: 215-224. PMID: 17675229, DOI: 10.1016/j.leukres.2007.06.012.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeFlow cytometryDiagnostic pitfallsMyelomonocytic cellsMDS/MPDClonal cytogenetic abnormalitiesGlobal evaluationImmunophenotypic aberranciesRetrospective reviewMorphological dysplasiaMarrow diseaseMyeloproliferative diseaseDiagnostic utilityCytogenetic abnormalitiesDisease casesMyeloid diseasesCytometric analysisOverall sensitivityAbnormalitiesDiseaseOverall abnormalitySyndromeIntermediate categoryInnovative Methods in Laboratory Medicine Resident Teaching
Rinder HM, Smith BR. Innovative Methods in Laboratory Medicine Resident Teaching. Clinics In Laboratory Medicine 2007, 27: 255-267. PMID: 17556084, DOI: 10.1016/j.cll.2007.03.003.Peer-Reviewed Original ResearchThe Goals of Resident Training in Laboratory Medicine in Combined Anatomic Pathology/Clinical Pathology Programs: An Overview
Wells A, Smith BR. The Goals of Resident Training in Laboratory Medicine in Combined Anatomic Pathology/Clinical Pathology Programs: An Overview. Clinics In Laboratory Medicine 2007, 27: 229-240. PMID: 17556082, DOI: 10.1016/j.cll.2007.03.001.Peer-Reviewed Original ResearchCirculating stem cells in extremely preterm neonates
Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.Peer-Reviewed Original ResearchConceptsWeeks of lifePreterm neonatesNeonatal morbidityPulmonary functionPremature neonatesGestational agePeripheral bloodInitial CD34Median gestational agePulmonary function testsShort-term outcomesUmbilical cord bloodFunction testsNeonatal demographicsBirth weightCord bloodRespiratory diseaseNeonatesCell countCD34Progenitor cellsInverse correlationWeeksBloodMorbidity