2006
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006, 46: 1130-1137. PMID: 16836559, DOI: 10.1111/j.1537-2995.2006.00861.x.Peer-Reviewed Original ResearchConceptsNeutrophil elastase releaseAnti-inflammatory activityAntithrombin IIICardiopulmonary bypassElastase releasePlatelet activationWhite blood cell activationDirect anti-inflammatory activitySystemic inflammatory reactionAbsence of endotheliumEndothelial effectsCardiac surgeryBlood cell activationAnticoagulant effectExtracorporeal circulationInflammatory reactionThrombin generationHigh doseClinical relevanceCell activationFibrin generationComplement activationThrombin activityStudy designCD11b
1994
In vitro characteristics of white cell‐reduced single‐unit platelet concentrates stored in syringes
Pisciotto PT, Snyder EL, Snyder JA, Frattaroli S, Hopfer SM, Rinder HM, Smith BR. In vitro characteristics of white cell‐reduced single‐unit platelet concentrates stored in syringes. Transfusion 1994, 34: 407-411. PMID: 8191565, DOI: 10.1046/j.1537-2995.1994.34594249052.x.Peer-Reviewed Original ResearchConceptsWBC filtrationP-selectin positivityPremature infantsDrug Administration requirementsPlatelet functionPlatelet activationPlatelet lossStudy designWhite cellsAdverse effectsPlatelet concentratesLactate productionTransfusionDegrees CVitro characteristicsAdministration requirementsSingle unitPlatelet propertiesLog10 reductionHoursSyringesConsumption of glucoseInfantsWBC