2003
Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival
Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 2003, 43: 1230-1237. PMID: 12919425, DOI: 10.1046/j.1537-2995.2003.00484.x.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIaAlpha-granule releaseAdverse metabolic conditionsIIb/IIIaPlatelet recoveryPlatelet concentratesMetabolic conditionsVivo platelet recoveryPlatelet secretory responseSevere metabolic stressOsmotic recoveryAgonist-induced bindingAutologous transfusionTransient derangementSecretory responseFunctional derangementFunctional abnormalitiesMembrane phosphatidylserine exposureMetabolic rescueNormal volunteersPlatelet survivalPosttransfusion recoveryPlatelet aggregationImproved functionSecretory function
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course