2007
Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation
Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation. The Annals Of Thoracic Surgery 2007, 83: 146-152. PMID: 17184649, DOI: 10.1016/j.athoracsur.2006.08.019.Peer-Reviewed Original ResearchConceptsC5a receptor blockadeC5a receptor antagonistReceptor antagonistExtracorporeal circulationReceptor blockadeCD11b upregulationElastase releasePlatelet P-selectin expressionComplement C5a anaphylatoxinNeutrophil CD11b upregulationSimulated Extracorporeal CirculationFresh heparinized whole bloodNeutrophil elastase releasePlasma interleukin-8P-selectin expressionInterleukin-8 releaseConjugate formationHeparinized whole bloodCardiopulmonary bypassInflammatory responseLeukocyte adhesive receptorsExtracorporeal circuitInterleukin-8Neutrophil chemotaxisDownregulatory effect
2006
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006, 46: 1130-1137. PMID: 16836559, DOI: 10.1111/j.1537-2995.2006.00861.x.Peer-Reviewed Original ResearchConceptsNeutrophil elastase releaseAnti-inflammatory activityAntithrombin IIICardiopulmonary bypassElastase releasePlatelet activationWhite blood cell activationDirect anti-inflammatory activitySystemic inflammatory reactionAbsence of endotheliumEndothelial effectsCardiac surgeryBlood cell activationAnticoagulant effectExtracorporeal circulationInflammatory reactionThrombin generationHigh doseClinical relevanceCell activationFibrin generationComplement activationThrombin activityStudy designCD11b