2007
Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation
Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation. The Annals Of Thoracic Surgery 2007, 83: 146-152. PMID: 17184649, DOI: 10.1016/j.athoracsur.2006.08.019.Peer-Reviewed Original ResearchConceptsC5a receptor blockadeC5a receptor antagonistReceptor antagonistExtracorporeal circulationReceptor blockadeCD11b upregulationElastase releasePlatelet P-selectin expressionComplement C5a anaphylatoxinNeutrophil CD11b upregulationSimulated Extracorporeal CirculationFresh heparinized whole bloodNeutrophil elastase releasePlasma interleukin-8P-selectin expressionInterleukin-8 releaseConjugate formationHeparinized whole bloodCardiopulmonary bypassInflammatory responseLeukocyte adhesive receptorsExtracorporeal circuitInterleukin-8Neutrophil chemotaxisDownregulatory effect
2003
Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Group M. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. The Annals Of Thoracic Surgery 2003, 75: 899-905. PMID: 12645714, DOI: 10.1016/s0003-4975(02)04490-9.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiopulmonary BypassCD11b AntigenCoronary Artery BypassCreatinineHeart FailureHeart Valve Prosthesis ImplantationHemodynamicsHumansIntra-Aortic Balloon PumpingLeukocyte CountMiddle AgedNeutrophilsPostoperative ComplicationsProspective StudiesRisk FactorsSystemic Inflammatory Response SyndromeConceptsAcute renal injuryNeutrophil CD11b upregulationRenal injuryCardiopulmonary bypassInflammatory responseCD11b upregulationAdult respiratory distress syndromeMarkers of leukocytesPlatelet CD62P expressionPostoperative hemodynamic supportPostoperative renal injuryNeutrophil inflammatory responseSystemic inflammatory responseRespiratory distress syndromeSubset of patientsC-reactive proteinTotal neutrophil countMonocyte CD11bRenal riskHemodynamic instabilityInflammatory markersPost-CPBHemodynamic supportMyeloperoxidase levelsNeutrophil count
1995
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.
Rinder CS, Rinder HM, Smith BR, Fitch JC, Smith MJ, Tracey JB, Matis LA, Squinto SP, Rollins SA. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. Journal Of Clinical Investigation 1995, 96: 1564-1572. PMID: 7657827, PMCID: PMC185782, DOI: 10.1172/jci118195.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassExtracorporeal circulationSerum complement hemolytic activityComplement activationComplement componentsP-selectin-positive plateletsC5 complement componentNeutrophil CD11b upregulationSystemic inflammatory responseBlockade of C5aComplement hemolytic activityC5b-9 generationNeutrophil activationCD11b upregulationControl MAbInflammatory responseTherapeutic interventionsPlatelet activationCellular activationC5b-9BypassC5aC3a generationConjugate formationPlatelets