2018
Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis
Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.Peer-Reviewed Original ResearchConceptsRestless legs syndromePrevalence of RLSConcurrent restless legs syndromePeriodic limb movementsMulti-Ethnic StudyLegs syndromeObesity statusOdds of RLSLimb movementsPrevalence of PLMSCommunity-based sampleRace/ethnicityRLS symptomsClinical criteriaAdjusted modelPLMSStudy participantsPrevalenceOlder individualsCross-sectional dataAtherosclerosisSexSyndromeWhite participantsSleep
2017
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delayObservational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study
Koo BB, Bravata DM, Tobias LA, Mackey JS, Miech EJ, Matthias MS, Stahl SM, Sico JJ, Fragoso C, Williams LS, Lampert R, Qin L, Yaggi HK. Observational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study. Cerebrovascular Diseases 2016, 41: 233-241. PMID: 26811929, DOI: 10.1159/000440736.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersBlood PressureBlood Pressure Monitoring, AmbulatoryBrain IschemiaChi-Square DistributionCholesterol, LDLConnecticutCross-Sectional StudiesFemaleHumansIndianaIschemic Attack, TransientLogistic ModelsMaleMiddle AgedOdds RatioOxygenPolysomnographyPrevalenceRandomized Controlled Trials as TopicRisk FactorsSeverity of Illness IndexSex FactorsSleepSleep Apnea, ObstructiveStrokeSympathetic Nervous SystemWakefulnessConceptsObstructive sleep apneaDiastolic blood pressureSevere obstructive sleep apneaLow-density lipoproteinBlood pressureSleep apneaSerum catecholaminesAmbulatory blood pressure monitoringBaseline diastolic blood pressureMean body mass indexB-type natriuretic peptideHigher diastolic blood pressureMore oxygen desaturationTransient ischemic attackIschemic stroke patientsAmbulatory blood pressureHistory of strokeBody mass indexC-reactive proteinBlood pressure monitoringOxygen desaturation eventsGender-stratified analysesCross-sectional analysisIschemic attackOSA frequency
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control
2014
Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis
Koo BB, Sillau S, Dean DA, Lutsey PL, Redline S. Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis. Hypertension 2014, 65: 70-77. PMID: 25287399, PMCID: PMC4268086, DOI: 10.1161/hypertensionaha.114.04193.Peer-Reviewed Original ResearchConceptsSystolic blood pressurePLMS-arousal indexPeriodic limb movementsPrevalent hypertensionBlood pressureOverall cohortPLMS indexArousal indexObserved systolic blood pressureLimb movementsCardiovascular risk factorsBlood pressure outcomesApnea-hypopnea indexCommunity-dwelling menBody mass indexType/doseMulti-Ethnic StudyRace/ethnicityAntihypertensive medicationsPLMS frequencyDiastolic BPMass indexPressure outcomesRisk factorsSBP values
2011
Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men
Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S, Group F. Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men. Circulation 2011, 124: 1223-1231. PMID: 21859975, PMCID: PMC3265562, DOI: 10.1161/circulationaha.111.038968.Peer-Reviewed Original ResearchConceptsCause cardiovascular diseaseCoronary heart diseasePeripheral arterial diseaseIncident cardiovascular diseasePeriodic limb movementsArterial diseaseCardiovascular diseaseCerebrovascular diseaseHeart diseasePLMS frequencyRelative hazardCommunity-dwelling elderly menConventional cardiovascular risk factorsPeripheral arterial disease eventsLimb movementsElderly male cohortCardiovascular risk factorsBody mass indexProportional hazards regressionRisk of incidentPrevalent hypertensionCardiovascular riskMass indexStudy cohortHazards regression
2008
Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender
Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender. CHEST Journal 2008, 134: 1156-1161. PMID: 18812455, PMCID: PMC7448537, DOI: 10.1378/chest.08-1311.Peer-Reviewed Original ResearchConceptsNREM AHIApnea-hypopnea indexSleep-disordered breathingREM apnea-hypopnea indexBody mass indexSDB prevalenceRapid eye movement (REM) sleepFace of obesityUniversity Sleep LaboratoryEye movement sleepRapid eye movementAge-dependent riseAge-related decreaseMass indexFemale sexBMI increaseMovement sleepRisk factorsFemale hormonesNREM sleepSleep laboratoryPrevalence decreasesBreathing influencesYoung womenWomen