2018
1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke
May A, Koo B, Yaffe K, Leng Y, Cawthon P, Redline S, Stone K, Mehra R. 1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke. Sleep 2018, 41: a376-a377. DOI: 10.1093/sleep/zsy061.1014.Peer-Reviewed Original ResearchBody mass indexIncident stroke riskPeriodic limb movementsStroke riskIncident strokeMulti-center prospective studyLimb movementsApnea-hypopnea indexAF findingsHypopnea indexMedian ageMedication useTotal cholesterolMass indexSleep apneaArousal indexProspective studyAutonomic dysregulationPhysical activityPLMSSignificant interactionStrokeLogistic regressionAlcohol useAge
2017
0720 ASSOCIATION OF INDIVIDUAL PERIODIC LIMB MOVEMENTS AND NON-SUSTAINED TACHYCARDIA DURING SLEEP: A CASE-CROSSOVER ANALYSIS
May A, May R, Bena J, Wang L, Monahan K, Stone K, Cawthon P, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0720 ASSOCIATION OF INDIVIDUAL PERIODIC LIMB MOVEMENTS AND NON-SUSTAINED TACHYCARDIA DURING SLEEP: A CASE-CROSSOVER ANALYSIS. Sleep 2017, 40: a266-a267. DOI: 10.1093/sleepj/zsx050.719.Peer-Reviewed Original ResearchPeriodic limb movementsRespiratory eventsOsteoporotic fracturesUnadjusted analysesNational InstituteSympathetic nervous system activationBidirectional case-crossover designLimb movementsControl periodNon-sustained tachycardiaApnea-hypopnea indexNervous system activationConditional logistic regressionVentricular tachycardia eventsCase-crossover analysisCase-crossover designAdvancing Translational SciencesPLMS indexBlood InstituteNational HeartTachycardia eventsVentricular arrhythmogenesisOdds ratioAncillary studiesNSVT
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delayRestless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency
2014
Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis
Koo BB, Sillau S, Dean DA, Lutsey PL, Redline S. Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis. Hypertension 2014, 65: 70-77. PMID: 25287399, PMCID: PMC4268086, DOI: 10.1161/hypertensionaha.114.04193.Peer-Reviewed Original ResearchConceptsSystolic blood pressurePLMS-arousal indexPeriodic limb movementsPrevalent hypertensionBlood pressureOverall cohortPLMS indexArousal indexObserved systolic blood pressureLimb movementsCardiovascular risk factorsBlood pressure outcomesApnea-hypopnea indexCommunity-dwelling menBody mass indexType/doseMulti-Ethnic StudyRace/ethnicityAntihypertensive medicationsPLMS frequencyDiastolic BPMass indexPressure outcomesRisk factorsSBP values
2008
Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender
Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid Eye Movement-Related Sleep-Disordered Breathing Influence of Age and Gender. CHEST Journal 2008, 134: 1156-1161. PMID: 18812455, PMCID: PMC7448537, DOI: 10.1378/chest.08-1311.Peer-Reviewed Original ResearchConceptsNREM AHIApnea-hypopnea indexSleep-disordered breathingREM apnea-hypopnea indexBody mass indexSDB prevalenceRapid eye movement (REM) sleepFace of obesityUniversity Sleep LaboratoryEye movement sleepRapid eye movementAge-dependent riseAge-related decreaseMass indexFemale sexBMI increaseMovement sleepRisk factorsFemale hormonesNREM sleepSleep laboratoryPrevalence decreasesBreathing influencesYoung womenWomen