2015
Normalization of brain morphology after surgery in sagittal craniosynostosis.
Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA. Normalization of brain morphology after surgery in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2015, 17: 460-8. PMID: 26684766, PMCID: PMC7182140, DOI: 10.3171/2015.7.peds15221.Peer-Reviewed Original ResearchConceptsBrain growthNonsyndromic craniosynostosisBrain morphological differencesWhole-brain techniqueYears of ageSignificant learning disabilitiesIQ-matched control subjectsUntreated infantsMean ageAdolescent patientsControl subjectsWhole-vault cranioplastyBrain dysmorphologySurgical reconstructionBrain areasTemporooccipital regionsSmall cohortSurgeryCognitive functionBrain morphologyBrain normalizationSagittal craniosynostosisLiberal thresholdSagittal nonsyndromic craniosynostosisFrontoparietal regions
2014
Altered brain connectivity in sagittal craniosynostosis.
Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingPosterior cingulate cortexCingulate cortexSagittal nonsyndromic craniosynostosisPrefrontal cortexRight posterior cingulate cortexBrodmann area 8Functional connectivity differencesRight middle frontal gyrusWhite matter alterationsAnterior cingulate cortexBrodmann area 7Left ventromedial prefrontal cortexAltered brain connectivityResting-state functional connectivity MRI dataMiddle frontal gyrusRight supramarginal gyrusDefault mode networkIntrinsic connectivity analysesSignificant group differencesAdolescent patientsAltered connectivityNeurocognitive morbidityHigh prevalenceRight parahippocampus