2013
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria. Human Molecular Genetics 2013, 22: 1601-1614. PMID: 23314018, PMCID: PMC3657477, DOI: 10.1093/hmg/ddt009.Peer-Reviewed Original ResearchConceptsDrosophila larval motor neuronsLarval motor neuronsAxonal mitochondriaRole of mitochondriaEvolutionary conservationMN axonsMorphological comparisonMotor neuronsMitochondriaMolecular pathwaysAxon protectionNeuronal mitochondriaWallerian degenerationNeurodegenerative diseasesCentral roleIntense investigationDistal axonsRegulationMorphological changesDorsal root ganglion explantsAxon degenerationHuman DRG neuronsCritical sitesUnderlying mechanismMislocalization
2007
Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery
Pearse DD, Sanchez AR, Pereira FC, Andrade CM, Puzis R, Pressman Y, Golden K, Kitay BM, Blits B, Wood PM, Bunge MB. Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery. Glia 2007, 55: 976-1000. PMID: 17526000, DOI: 10.1002/glia.20490.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBrain Tissue TransplantationCell CommunicationCell MovementCell SurvivalFemaleGenetic MarkersGenotypeGraft SurvivalGreen Fluorescent ProteinsMaleNeural PathwaysOlfactory BulbRatsRats, Inbred F344Recovery of FunctionSchwann CellsSpinal Cord InjuriesTreatment OutcomeY ChromosomeConceptsContused spinal cordSchwann cellsSpinal cordFunctional recoveryAdult rat spinal cordGrafted Schwann cellsSpinal cord injury repairRat spinal cordLentiviral vector-mediated expressionNumerous myelinated axonsLong-term markersVector-mediated expressionInjury milieuHost axonsMale transplantsGrafted cellsFemale ratsInjury siteCentral canalInjury repairY chromosome-specific probesMyelinated axonsSurvival rateLesionsTransplanted cells