Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
Ali YO, Kitay BM, Zhai RG. Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration. Molecules 2010, 15: 6859-6887. PMID: 20938400, PMCID: PMC3133442, DOI: 10.3390/molecules15106859.Peer-Reviewed Original ResearchConceptsMolecular chaperonesMisfolded proteinsNormal protein homeostasisRepair of proteinsProtein-protein interactionsHuman neurodegenerative diseasesNeurodegenerative diseasesNascent proteinsProtein homeostasisNetwork of moleculesCellular functionsConformational diseasesProteolytic machineryProtein speciesCellular stressChaperonesClearance of proteinsNormal proteinProteinFunctional classificationSuch diseasesFoldingEnvironmental factorsWide arrayTherapeutic potential