Lifetime history of childhood adversity and substance abuse in patients with treatment resistant depression
Giampetruzzi E, McDonald W, Rice H, Kitay B, Hermida A, Posse P, Hershenberg R. Lifetime history of childhood adversity and substance abuse in patients with treatment resistant depression. Personalized Medicine In Psychiatry 2024, 43: 100122. DOI: 10.1016/j.pmip.2024.100122.Peer-Reviewed Original ResearchTreatment-resistant depressionAdverse childhood experiencesHistory of substance abuseSubstance abuseDepressive disorderAssociated with treatment-resistant depressionTreatment-resistant depressed patientsPersistent depressive disorderLifetime substance abuseEffects of adverse childhood experiencesRisk of substance abuseAssociation of adverse childhood experiencesACE subtypesACE exposureResistant depressionLifetime historyChildhood adversityChildhood experiencesAbuseClinical samplesDepressionDisordersLogistic regression analysisMDDSubstances