2013
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria. Human Molecular Genetics 2013, 22: 1601-1614. PMID: 23314018, PMCID: PMC3657477, DOI: 10.1093/hmg/ddt009.Peer-Reviewed Original ResearchConceptsDrosophila larval motor neuronsLarval motor neuronsAxonal mitochondriaRole of mitochondriaEvolutionary conservationMN axonsMorphological comparisonMotor neuronsMitochondriaMolecular pathwaysAxon protectionNeuronal mitochondriaWallerian degenerationNeurodegenerative diseasesCentral roleIntense investigationDistal axonsRegulationMorphological changesDorsal root ganglion explantsAxon degenerationHuman DRG neuronsCritical sitesUnderlying mechanismMislocalization
2010
Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
Ali YO, Kitay BM, Zhai RG. Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration. Molecules 2010, 15: 6859-6887. PMID: 20938400, PMCID: PMC3133442, DOI: 10.3390/molecules15106859.Peer-Reviewed Original ResearchConceptsMolecular chaperonesMisfolded proteinsNormal protein homeostasisRepair of proteinsProtein-protein interactionsHuman neurodegenerative diseasesNeurodegenerative diseasesNascent proteinsProtein homeostasisNetwork of moleculesCellular functionsConformational diseasesProteolytic machineryProtein speciesCellular stressChaperonesClearance of proteinsNormal proteinProteinFunctional classificationSuch diseasesFoldingEnvironmental factorsWide arrayTherapeutic potential