Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria. Human Molecular Genetics 2013, 22: 1601-1614. PMID: 23314018, PMCID: PMC3657477, DOI: 10.1093/hmg/ddt009.Peer-Reviewed Original ResearchConceptsDrosophila larval motor neuronsLarval motor neuronsAxonal mitochondriaRole of mitochondriaEvolutionary conservationMN axonsMorphological comparisonMotor neuronsMitochondriaMolecular pathwaysAxon protectionNeuronal mitochondriaWallerian degenerationNeurodegenerative diseasesCentral roleIntense investigationDistal axonsRegulationMorphological changesDorsal root ganglion explantsAxon degenerationHuman DRG neuronsCritical sitesUnderlying mechanismMislocalization