2023
Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Knoedler L, Knoedler S, Allam O, Remy K, Miragall M, Safi A, Alfertshofer M, Pomahac B, Kauke-Navarro M. Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review. Frontiers In Surgery 2023, 10: 1266399. PMID: 38026484, PMCID: PMC10646214, DOI: 10.3389/fsurg.2023.1266399.Peer-Reviewed Original ResearchComposite allotransplantationLong-term outcomesFacial trauma patientsSevere facial disfigurementRejection episodesSurgical treatmentTrauma patientsMalignancy screeningReconstructive surgeryClinical challengeFacial traumaPaucity of studiesReconstructive strategiesNarrative reviewPatientsFacial disfigurementAllotransplantationFuture studiesSurgeryDiagnosisTraumaDisfigurementCellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell types
2022
The Value of Upper Extremity, face, and uterus transplantation: A Summit Conference
Tintle S, Shores J, Azari K, Tzakis A, Dearden M, Porrett P, Johannesson L, McDiarmid S, Pomahac B, Levin L. The Value of Upper Extremity, face, and uterus transplantation: A Summit Conference. Orthoplastic Surgery 2022, 10: 41-46. DOI: 10.1016/j.orthop.2022.08.008.Peer-Reviewed Original ResearchVascular composite allotransplantationComposite allotransplantationUpper extremityUterus transplantationAmerican SocietyMajor transplant centersTransplant centersConsensus guidelinesTransplant surgeonsTransplantation communityReconstructive transplantationTransplantationAllotransplantationReproductive medicineUniformed Services UniversityExtremitiesUnited StatesPanel membersHealth SciencesServices UniversityBethesda MDContraindicationsSurgeons317.6: Anti-donor Human Leukocyte Antigen (HLA) Antibody Response After Vascularized Composite Allotransplantation: A Multicenter Study
Petruzzo P, Wehrlen G, Kanitakis J, Morelon E, Badet L, Devauchelle B, Gazarian A, Sardu C, Dogan O, Kaminska D, Kay S, Lassus P, Pomahac B, Talbot S, Dubois V, Thaunat O. 317.6: Anti-donor Human Leukocyte Antigen (HLA) Antibody Response After Vascularized Composite Allotransplantation: A Multicenter Study. Transplantation 2022, 106: s258-s258. DOI: 10.1097/01.tp.0000886728.39559.3f.Peer-Reviewed Original Research
2019
Face transplantation
Sinha I, Vyas R, Pomahac B. Face transplantation. 2019, 379-382. DOI: 10.1093/med/9780199699537.003.0045.Peer-Reviewed Original ResearchReturn of sensationSevere traumatic injuryComposite tissue allotransplantationComposite tissue transplantationFacial composite tissue allotransplantationTransplanted allograftPost transplantationLifelong immunosuppressionMotor functionTraumatic injuryTissue allotransplantationPsychiatric issuesPatientsTissue transplantationInfection riskTransplantationFace transplantationFacial formImmunosuppressionAllograftsAllotransplantationInjuryPossible rejectionMonths
2018
Living Donation of Vascularized Composite Allografts
Pomahac B, Alhefzi M, Bueno E, McDiarmid S, Levin L. Living Donation of Vascularized Composite Allografts. Plastic & Reconstructive Surgery 2018, 142: 405e-411e. PMID: 29927830, DOI: 10.1097/prs.0000000000004659.Peer-Reviewed Original ResearchConceptsComposite allotransplantationComposite allograftsOrgan procurementSolid organ transplantationVascularized Composite AllograftsKidney transplant communityCurrent guidelinesOrgan transplantationTransplant communityTransplantation SocietyClinical scenariosReconstructive strategiesAesthetic outcomeTransplantation NetworkReconstructive ladderReconstructive surgeonTransplant medicineOrgan donationAllotransplantationMedicaid ServicesEthics CommitteeAllograftsDonationSpecific recommendationsExtensive type
2017
Role of Facial Vascularized Composite Allotransplantation in Burn Patients
Bharadia D, Sinha I, Pomahac B. Role of Facial Vascularized Composite Allotransplantation in Burn Patients. Clinics In Plastic Surgery 2017, 44: 857-864. PMID: 28888310, DOI: 10.1016/j.cps.2017.05.017.Peer-Reviewed Original ResearchConceptsComposite allotransplantationFacial Vascularized Composite AllotransplantationExtensive burn injuriesRisk of rejectionVascularized Composite AllotransplantationQuality of lifeLifelong regimenVCA patientsImmunosuppression medicationsPowerful reconstructive toolsBurn patientsTreatment optionsSurgical techniqueBurn injuryReconstructive surgeryPatientsReconstructive toolFace transplantationAllotransplantationImproved qualityFacial formImmunosuppressionMedicationsRegimenSurgeryChronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation
Krezdorn N, Pomahac B. Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation. American Journal Of Transplantation 2017, 17: 1703-1704. PMID: 28371193, DOI: 10.1111/ajt.14291.Peer-Reviewed Original ResearchAvascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report
Rinkinen J, Molway D, Carty M, Dyer G, Pomahac B, Chandraker A, Talbot S. Avascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report. Case Reports In Plastic Surgery And Hand Surgery 2017, 4: 60-64. PMID: 28804740, PMCID: PMC5532758, DOI: 10.1080/23320885.2017.1345635.Peer-Reviewed Original Research
2016
Treatment of Rejection in Vascularized Composite Allotransplantation
Alhefzi M, Aycart M, Bueno E, Kiwanuka H, Krezdorn N, Pomahac B, Tullius S. Treatment of Rejection in Vascularized Composite Allotransplantation. Current Transplantation Reports 2016, 3: 404-409. DOI: 10.1007/s40472-016-0128-3.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationAcute rejectionChronic rejectionComposite allotransplantationTreatment of rejectionConventional reconstructive techniquesCommon complicationReconstructive techniquesEsthetic outcomeTherapeutic strategiesImportant modalityAllotransplantationRecent reportsTreatmentRejectionAllograftsComplicationsPrevention2530: Unilateral facial artery is sufficient for vascularized composite allotransplantation of the lower two-thirds of the face - Case report on a face transplant recipient at the Brigham and Women's Hospital
Fischer S, Lee T, Krezdorn N, Alhefzi M, Aycart M, Kiwanuka H, Win T, Bueno E, Tullius S, Pomahac B. 2530: Unilateral facial artery is sufficient for vascularized composite allotransplantation of the lower two-thirds of the face - Case report on a face transplant recipient at the Brigham and Women's Hospital. Vascularized Composite Allotransplantation 2016, 3: 44-44. DOI: 10.1080/23723505.2016.1234256.Peer-Reviewed Original Research
2015
Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation
Kueckelhaus M, Turk M, Kumamaru K, Wo L, Bueno E, Lian C, Alhefzi M, Aycart M, Fischer S, De Girolami U, Murphy G, Rybicki F, Pomahac B. Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation. American Journal Of Transplantation 2015, 16: 968-978. PMID: 26639618, DOI: 10.1111/ajt.13544.Peer-Reviewed Original ResearchConceptsLong-term outcomesFacial allograftFacial allotransplantationSuperior long-term outcomesShort-term resultsRisk-benefit assessmentSoft tissue volumeSignificant volume lossTransplant recipientsVolume lossDiagnostic evaluationDonor selectionMuscle biopsyHistological evaluationComputed tomographyBone atrophyAllograftsFuture clinical routineNormal anatomyRecipient tissuesAllotransplantationClinical routineMorphometric changesSoft tissueMuscle fibersFacial transplantation
Wo L, Bueno E, Pomahac B. Facial transplantation. Current Opinion In Organ Transplantation 2015, Publish Ahead of Print: &na;. PMID: 26536422, DOI: 10.1097/mot.0000000000000253.Peer-Reviewed Original ResearchConceptsPositive HIV statusHIV statusFace transplantComposite allotransplantationUpper extremity transplantsDonor-specific antigensHistory of malignancyLatent viral infectionFacial transplantationChronic rejectionSimultaneous transplantationAbsolute contraindicationCase reportCurrent guidelinesFacial injuriesViral infectionTransplantTransplantationMedical teamAllotransplantationFirst face transplantFace transplantationFacial allotransplantationPatientsPsychological health
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
2013
Split rejection in vascularized composite allotransplantation.
Sinha I, Pomahac B. Split rejection in vascularized composite allotransplantation. Eplasty 2013, 13: e53. PMID: 24244785, PMCID: PMC3795428.Peer-Reviewed Original ResearchCurrent Principles of Facial Allotransplantation
Pomahac B, Bueno E, Sisk G, Pribaz J. Current Principles of Facial Allotransplantation. Plastic & Reconstructive Surgery 2013, 131: 1069-1076. PMID: 23629089, PMCID: PMC4374342, DOI: 10.1097/prs.0b013e3182865cd3.Peer-Reviewed Original ResearchConceptsTransplant recipientsSurgical principlesFace transplant recipientsFacial allotransplantationFull screening procedureReturn of motorFace transplant candidatesFundamental surgical principlesTransplant candidatesTransplantation teamWomen's HospitalSevere casesSensory functionPatientsUnique caseAllotransplantationClinical volumeFacial disfigurementRecipientsHospitalScreening procedureFacial restorationCurrent principlesBrigham
2011
Establishing a Composite Tissue Allotransplantation Program
Pomahac B. Establishing a Composite Tissue Allotransplantation Program. Journal Of Reconstructive Microsurgery 2011, 28: 03-06. PMID: 21811966, DOI: 10.1055/s-0031-1285823.Peer-Reviewed Original ResearchConceptsComposite tissue allotransplantationPromising surgical optionPotential patient safety issuesLife-long immunosuppressionPatient safety issuesClinical research interestInstitutional review boardSurgical optionsPostoperative costsWomen's HospitalTissue allotransplantationMultidisciplinary teamMedical careCTA programReview boardHospital administrationLogistic hurdlesMedical insuranceHospitalAdministrationUnited StatesSafety issuesImmunosuppressionPatientsAllotransplantation