2024
Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue T, Guo Y, Qi X, Zheng W, Zhang H, Wang B, Liu K, Zhou B, Zeng X, Ouzhuluobu, He Y, Su B. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development. ELife 2024, 12: rp89004. PMID: 38869160, PMCID: PMC11175615, DOI: 10.7554/elife.89004.Peer-Reviewed Original ResearchConceptsExpression divergenceHigh birth weightFull-term placentaDecreased immune responseSyncytial knotsMale newbornsEndoplasmic reticulum stressPlacental trophoblastsFetal developmentUmbilical cordBirth weightHan migrantsNative TibetansUmbilical artery wallImmune responseStudy of human reproductionPlacentaAdaptation of human populationsHistological changesBetween-population differencesReticulum stressMigrantsHuman reproductionBetween-populationReproductive success
2020
Tracing the Genetic Legacy of the Tibetan Empire in the Balti
Yang X, Rakha A, Chen W, Hou J, Qi X, Shen Q, Dai S, Sulaiman X, Abdulloevich N, Afanasevna M, Ibrohimovich K, Chen X, Yang W, Adnan A, Zhao R, Yao Y, Su B, Peng M, Zhang Y. Tracing the Genetic Legacy of the Tibetan Empire in the Balti. Molecular Biology And Evolution 2020, 38: 1529-1536. PMID: 33283852, PMCID: PMC8042757, DOI: 10.1093/molbev/msaa313.Peer-Reviewed Original ResearchConceptsAnalysis of mitochondrial DNATibetan EmpireX chromosome dataMale-biased dispersalAdmixture eventsDemographic historyMitochondrial DNAGenetic legacyGenetic impactTibetan ancestryCourse of historyDemic diffusionGenomeEast EurasiaEmpireTibetan malesBaltistanHistoryAncestryDNABaltiGeneticsTibetanTibetan languagePeople
2007
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
Deng Y, Yang J, McCarty M, Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. American Journal Of Physiology - Cell Physiology 2007, 293: c1404-c1411. PMID: 17687003, DOI: 10.1152/ajpcell.00058.2007.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1AnimalsAortaApoptosisCell ProliferationEmbryo, MammalianEndocardiumEndothelial CellsEndothelium, VascularFemaleMAP Kinase Kinase Kinase 3MiceMice, Inbred StrainsMice, KnockoutMice, NudeMitogen-Activated Protein KinasesMyocardiumNeoplasms, ExperimentalNeoplastic Stem CellsNeovascularization, PathologicPhosphorylationReceptor, TIE-2Vascular Endothelial Growth Factor AConceptsEmbryonic angiogenesisProtein kinase kinase kinase 3Embryonic stem cell linesEarly embryonic developmentCell proliferationStem cell linesTumor angiogenesisTumor growthEmbryonic developmentEndothelial cellsKinase 3ERK5 activationMEKK3Endothelial cell proliferationAng1/Tie2Essential roleCell linesProduction of VEGFCritical roleEmbryosAngiogenesisFactor productionProliferationGrowthCells